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Search: authors:"J. B. C. Carvalheira"

12 papers found.
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Cytotoxic drugs for patients with breast cancer in the era of targeted treatment: back to the future?

Background: Despite current trend of targeted therapy development, cytotoxic agents are a mainstay of treatment of patients with breast cancer. We reviewed recent advances in cytotoxic therapy for patients with metastatic breast cancer (MBC).

Modulation of gut microbiota by antibiotics improves insulin signalling in high-fat fed mice

. Dias L. T. Kubota J. B. C. Carvalheira M. J. A. Saad 0 ) Internal Medicine Department-Faculty of Medical Sciences, State University of Campinas, Rua Tessália Vieira de Camargo , 126, Cidade

Circulating ghrelin concentrations are lowered by intracerebroventricular insulin

M. Ueno J. B. C. Carvalheira R. L. G. S. Oliveira L. A. Velloso M. J. A. Saad 0 ) Department of Internal Medicine, State University of Campinas (UNICAMP) , Campinas, So Paulo 13081-970, Brazil Aims

Aspirin attenuates insulin resistance in muscle of diet-induced obese rats by inhibiting inducible nitric oxide synthase production and S-nitrosylation of IRβ/IRS-1 and Akt

Aim/hypothesis High-dose aspirin treatment improves fasting and postprandial hyperglycaemia in patients with type 2 diabetes, as well as in animal models of insulin resistance associated with obesity and sepsis. In this study, we investigated the effects of aspirin treatment on inducible nitric oxide synthase (iNOS)-mediated insulin resistance and on S-nitrosylation of insulin ...

l-glutamine supplementation induces insulin resistance in adipose tissue and improves insulin signalling in liver and muscle of rats with diet-induced obesity

Aims/hypothesis Diet-induced obesity (DIO) is associated with insulin resistance in liver and muscle, but not in adipose tissue. Mice with fat-specific disruption of the gene encoding the insulin receptor are protected against DIO and glucose intolerance. In cell culture, glutamine induces insulin resistance in adipocytes, but has no effect in muscle cells. We investigated whether ...

Regulation of insulin signalling by hyperinsulinaemia: role of IRS-1/2 serine phosphorylation and the mTOR/p70 S6K pathway

M. Ueno . J. B. C. Carvalheira . R. C. Tambascia . R. M. N. Bezerra . M. E. Amaral . E. M. Carneiro . F. Folli . K. G. Franchini . M. J. A. Saad 0 0 F. Folli Department of Internal Medicine , HS

Insulin signalling pathways in aorta and muscle from two animal models of insulin resistance—the obese middle-aged and the spontaneously hypertensive rats

Aims/hypothesis The aim of this study was to investigate insulin signalling pathways directly in vivo in skeletal muscle and thoracic aorta from obese middle-aged (12-month-old) rats, which have insulin resistance but not cardiovascular disease, and from spontaneously hypertensive rats (SHR), an experimental model of insulin resistance and cardiovascular disease. Methods We have ...

Selective impairment of insulin signalling in the hypothalamus of obese Zucker rats

Aim/hypothesis By acting in the brain, insulin suppresses food intake. However, little is known with regard to insulin signalling in the hypothalamus in insulin-resistant states. Methods Western blotting, immunohistochemistry and polymerase chain reaction assays were combined to compare in vivo hypothalamic insulin signalling through the PI3-kinase and MAP kinase pathways between ...