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104 papers found.
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Prevalence of binary toxin positive Clostridium difficile in diarrhoeal humans in the absence of epidemic ribotype 027

, Daniel R. Knight. Methodology: Alan M. McGovern. Resources: Mark W. Watson, Thomas V. Riley. 8 / 10 Supervision: Briony Elliott, Niki F. Foster, Barbara J. Chang, Thomas V. Riley. Writing ± original

Rodents and humans are able to detect the odour of L-Lactate

L-Lactate (LL) is an essential cellular metabolite which can be used to generate energy. In addition, accumulating evidence suggests that LL is used for inter-cellular signalling. Some LL-sensitive receptors have been identified but we recently proposed that there may be yet another unknown G-protein coupled receptor (GPCR) sensitive to LL in the brain. Olfactory receptors (ORs...

Three Different Approaches to the Inferior Mesenteric Artery during Robotic D3 Lymphadenectomy for Rectal Cancer

. Chang MS 1 0 Colorectal Division, Department of Surgery, Chulalongkorn University , Bangkok , Thailand 1 Division of Surgery, Department of Surgical Oncology, The University of Texas MD Anderson Cancer

Applying Dose Reduction to CT Colonography

polyps. Compliance with Ethics Guidelines Conflict of Interest Judy Yee, Kevin J. Chang, and Stefanie Weinstein declare that they have no conflicts of interest. Human and Animal Rights and Informed

Validation of the Fitbit One® for physical activity measurement at an upper torso attachment site

Background The upper torso is recommended as an attachment site for the Fitbit One®, one of the most common wireless physical activity trackers in the consumer market, and could represent a viable alternative to wrist- and hip-attachment sites. The objective of this study was to provide evidence concerning the validity of the Fitbit One® attached to the upper torso for measuring...

Identification of the Calmodulin-Binding Domains of Fas Death Receptor

The extrinsic apoptotic pathway is initiated by binding of a Fas ligand to the ectodomain of the surface death receptor Fas protein. Subsequently, the intracellular death domain of Fas (FasDD) and that of the Fas-associated protein (FADD) interact to form the core of the death-inducing signaling complex (DISC), a crucial step for activation of caspases that induce cell death...

A Sensitive and Specific Neural Signature for Picture-Induced Negative Affect

Neuroimaging has identified many correlates of emotion but has not yet yielded brain representations predictive of the intensity of emotional experiences in individuals. We used machine learning to identify a sensitive and specific signature of emotional responses to aversive images. This signature predicted the intensity of negative emotion in individual participants in cross...

Comparative Effectiveness of Laparoscopy vs Open Colectomy Among Nonmetastatic Colon Cancer Patients: An Analysis Using the National Cancer Data Base

Background: Randomized clinical trials showed that laparoscopic colectomy (LC) is superior to open colectomy (OC) in short-term surgical outcomes; however, the generalizability among real-world patients is not clear.

Transthoracic Port Placement Increases Safety of Total Laparoscopic Posterior Sectionectomy

Background Anatomic posterior sectionectomy is performed infrequently due to the challenges of controlling the right posterior portal pedicle (RPPP) while preserving the anterior pedicle (RAPP), difficulty of visualizing the drainage of the right hepatic vein into the IVC, and the potential for significant blood loss during the caval and hepatovenous dissection. Patient A 62-year...

Great expectations: neural computations underlying the use of social norms in decision-making

Social expectations play a critical role in everyday decision-making. However, their precise neuro-computational role in the decision process remains unknown. Here we adopt a decision neuroscience framework by combining methods and theories from psychology, economics and neuroscience to outline a novel, expectation-based, computational model of social preferences. Results...

Functional Improvement in Older Adults after a Falls Prevention Pilot Study

Falls are a costly, disabling, and life-threatening risk in the elderly. Improvements in physical function, balance, lower extremity strength, and health-related quality of life are hypothesized to help mitigate fall risk. In this pilot study, six women and men with an average age of 81 years participated in a 6-week exercise and education program created to reduce risk of falls...

PW02-038 - Treatment-resistant NOMID with autoantibodies

Competing interests L. Broderick: None declared, J. Chang: None declared, I. Szer: None declared, H. Hoffman Consultant for: Sobi, Novartis and Regeneron - From 7th Congress of International Society of

Progression-free and overall survival in ovarian cancer patients treated with CVac, a mucin 1 dendritic cell therapy in a randomized phase 2 trial

Background CAN-003 was a randomized, open-label, Phase 2 trial evaluating the safety, efficacy and immune outcomes of CVac, a mucin 1 targeted-dendritic cell (DC) treatment as a maintenance therapy to patients with epithelial ovarian cancer (EOC). Methods Patients (n = 56) in first (CR1) or second clinical remission (CR2) were randomized (1:1) to standard of care (SOC...

A Proteomics Approach to Investigate miR-153-3p and miR-205-5p Targets in Neuroblastoma Cells

MicroRNAs are key regulators associated with numerous diseases. In HEK293 cells, miR-153-3p and miR-205-5p down-regulate alpha-synuclein (SNCA) and Leucine-rich repeat kinase 2 (LRRK2), two key proteins involved in Parkinson’s disease (PD). We have used two-dimensional gel electrophoresis (2D-PAGE) coupled to mass spectrometry (MS) to identify a spectrum of miR-153-3p and miR-205...

Knockdown of Inner Arm Protein IC138 in Trypanosoma brucei Causes Defective Motility and Flagellar Detachment

Motility in the protozoan parasite Trypanosoma brucei is conferred by a single flagellum, attached alongside the cell, which moves the cell forward using a beat that is generated from tip-to-base. We are interested in characterizing components that regulate flagellar beating, in this study we extend the characterization of TbIC138, the ortholog of a dynein intermediate chain that...

KRAS Mutations and Rectal Cancer Response to Chemoradiation: Are We Closer to Personalization of Therapy?

Sunil Krishnan 1 George J. Chang MS 0 0 Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center , Houston, TX 1 Department of Radiation Oncology, The University of Texas

CTLA-4 polymorphisms and haplotype correlate with survival in ALL after allogeneic stem cell transplantation from related HLA-haplotype-mismatched donor

Background Allogeneic hematopoietic stem cell transplantation (allo-HSCT) has been established as an effective treatment for patients with hematological malignancies. Disease relapse remains a major cause of transplant failure. T cell homeostasis is critical to determine the potency of the GVT effect. Recent studies have shown the association of the CTLA-4 polymorphisms with the...

Generation of Monoclonal Antibodies against Dengue Virus Type 4 and Identification of Enhancing Epitopes on Envelope Protein

independent experiments. (TIF) The authors would like to thank the Core Facility of the Institute of Cellular and Organismic Biology for experimental assistance, and Dr. Gwong-Jen J. Chang of the Arbovirus

Hypofractionated SBRT versus conventionally fractionated EBRT for prostate cancer: comparison of PSA slope and nadir

Background Patients with early stage prostate cancer have a variety of curative radiotherapy options, including conventionally-fractionated external beam radiotherapy (CF-EBRT) and hypofractionated stereotactic body radiotherapy (SBRT). Although results of CF-EBRT are well known, the use of SBRT for prostate cancer is a more recent development, and long-term follow-up is not yet...