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Epidemiology of Chikungunya in the Americas

Chikungunya virus (CHIKV) emerged in the Americas in late 2013 to cause substantial acute and chronic morbidity. About 1.1 million cases of chikungunya were reported within a year, including severe cases and deaths. The burden of chikungunya is unclear owing to inadequate disease surveillance and underdiagnosis. Virus evolution, globalization, and climate change may further CHIKV...

Jamestown Canyon Virus Disease in the United States—2000–2013

Health Services, Madison, Wisconsin; New York State Department of Health and Wadsworth Center , Albany , New York 2 Authors' addresses: Daniel M. Pastula , Marc Fischer, and J. Erin Staples, CDC Arboviral

Nowcasting the Spread of Chikungunya Virus in the Americas

J. Erin Staples 0 Lisa F.P. Ng, Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR), Singapore 0 1 Division of Vector-Borne Diseases, Centers for Diseases Control and

Chikungunya Virus Infections Among Travelers–United States, 2010–2013

, Janeen Laven, J. Erin Staples, and Marc Fischer, Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, CO, E-mails: , , , estaples@cdc .gov, and . Harry E. Prince

Initial and Long-Term Costs of Patients Hospitalized with West Nile Virus Disease

, Atlanta , Georgia 2 Authors' addresses: J. Erin Staples and Marc Fischer, Arboviral Dis- eases Branch, Division of Vector-Borne Disease, Centers for Disease Control and Prevention , Fort Collins, CO There

Yellow Fever in Africa: Estimating the Burden of Disease and Impact of Mass Vaccination from Outbreak and Serological Data

Neil Ferguson and colleagues estimate the disease burden of yellow fever in Africa, as well as the impact of mass vaccination campaigns. Please see later in the article for the Editors' Summary

Medical Risk Factors for Severe West Nile Virus Disease, United States, 2008–2010

0 Branch, Centers for Disease Control and Prevention , 3150 Rampart Road, Fort Collins, CO 80521 1 J. Erin Staples, Jennifer A. Lehman, and Marc Fischer Arboviral Diseases Branch, Centers for Disease ... conclusions of the authors and do not necessarily represent the views of the Centers for Disease Control and Prevention. Authors addresses: Nicole P. Lindsey, J. Erin Staples, Jennifer A. Lehman, and Marc

Heartland Virus–Associated Death in Tennessee

Background. Heartland virus (HRTV) is a tick-borne phlebovirus recently described in Missouri that is associated with fever, leukopenia, and thrombocytopenia. The virus has also been detected in Ambylomma americanum ticks. Methods. Here we report the first fatal case of HRTV disease in an 80-year-old Tennessee resident. He was hospitalized with fever, confusion, leukopenia, and...

Assessing the Risk of International Spread of Yellow Fever Virus: A Mathematical Analysis of an Urban Outbreak in Asunción, 2008

Diseases, Centers for Disease Control and Prevention, San Juan, Puerto Rico, E-mails: mjohan and . Brad J. Biggerstaff and J. Erin Staples, Division of Vector-Borne Diseases, Centers for Disease Control and

On the Treatment of Airline Travelers in Mathematical Models

The global spread of infectious diseases is facilitated by the ability of infected humans to travel thousands of miles in short time spans, rapidly transporting pathogens to distant locations. Mathematical models of the actual and potential spread of specific pathogens can assist public health planning in the case of such an event. Models should generally be parsimonious, but...

Chikungunya Fever: An Epidemiological Review of a Re-Emerging Infectious Disease

Chikungunya fever is an acute febrile illness associated with severe, often debilitating polyarthralgias. The disease is caused by Chikungunya virus (CHIKV), an arthropod-borne virus that is transmitted to humans primarily via the bite of an infected mosquito. Since a re-emergence of CHIKV in 2004, the virus has spread into novel locations, such as Europe, and has led to millions...

Detection of Anti-Yellow Fever Virus Immunoglobulin M Antibodies at 3–4 Years Following Yellow Fever Vaccination

0 Amanda J. Panella , Olga I. Kosoy, Mark J. Delorey, Robert S. Lanciotti, Mark J. Mulligan, Marc Fischer, and J. Erin Staples 1 Diseases, Centers for Disease Control and Prevention (CDC) , 3156

Chikungunya Fever in the United States: A Fifteen Year Review of Cases

Background. Chikungunya virus (CHIKV) represents a threat to the United States, because humans amplify CHIKV and vectors that transmit CHIKV are present. Methods. We described the epidemiology of laboratory-confirmed chikungunya fever (CHIK) cases in the United States in 1995–2009 and compared states with CHIKV vectors with states with returning viremic CHIK cases. For 2006–2009...

Modifiable Risk Factors for West Nile Virus Infection during an Outbreak—Arizona, 2010

: . Katherine MacMillan, Mark J. Delorey, John-Paul Mutebi, Marc Fischer, and J. Erin Staples, Division of Vector-borne Disease, Centers for Disease Control and Prevention, Fort Collins, CO, E-mails: , , , , and .

West Nile Virus RNA Not Detected in Urine of 40 People Tested 6 Years After Acute West Nile Virus Disease

West Nile virus (WNV) causes an acute infection that is usually cleared by an effective immune response after several days of viremia. However, a recent study detected WNV RNA in the urine of 5 of 25 persons (20%) tested several years after their initial acute WNV disease. We evaluated an established cohort of 40 persons >6 years after initial infection with WNV. Urine collected...

Influenza-Like Illness in a Community Surrounding a School-Based Outbreak of 2009 Pandemic Influenza A (H1N1) Virus–Chicago, Illinois, 2009

In April 2009, following the first school closure due to 2009 pandemic influenza A (H1N1) (pH1N1) in Chicago, Illinois, area hospitals were inundated with patients presenting with influenza-like illness (ILI). The extent of disease spread into the surrounding community was unclear. We performed a household survey to estimate the ILI attack rate among community residents and...

Molecular Epidemiology of Francisella tularensis in the United States

Background. In the United States, tularemia is caused by Francisella tularensis subsps. tularensis (type A) and holarctica (type B). Molecular subtyping has further divided type A into 2 subpopulations, A1 and A2. Significant mortality differences were previously identified between human infections caused by A1 (14%), A2 (0%) and type B (7%). To verify these findings and to...

Spatial Risk Models for Human Plague in the West Nile Region of Uganda

The West Nile region of Uganda represents an epidemiologic focus for human plague in east Africa. However, limited capacity for diagnostic laboratory testing means few clinically diagnosed cases are confirmed and the true burden of disease is undetermined. The aims of the study were 1) describe the spatial distribution of clinical plague cases in the region, 2) identify ecologic...