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Giant impact: accretion and evolution of the Moon - Implications for Earth, Mars and the Solar System as a whole

and H.J. Melosh , Nature 485 , 75 ( 2012 ); W.F. Bottke , D. Vokrouhlicky , D. Minton et al., Nature 485 , 78 ( 2012 ). [9] R. Kallenbach , J. Geiss and W.K. Hartmann , Space Sci Ser ISSI (SSSI) 12

2'-O-methylation of the mRNA cap protects RNAs from decapping and degradation by DXO

Conceptualization: FreÂdeÂric Picard-Jean, Carolin Brand, Maude Tremblay-LeÂtourneau, AndreÂa Allaire, Simon Boudreault, Cyntia Duval, Francis Robert, Jerry Pelletier, Brian J. Geiss, Martin Bisaillon. 12 / 14 Data ... . Investigation: Brian J. Geiss, Martin Bisaillon. Methodology: FreÂdeÂric Picard-Jean, Carolin Brand, Maude Tremblay-LeÂtourneau, AndreÂa Allaire, Maxime C. Beaudoin, Simon Boudreault, Cyntia Duval, Martin

Murine Efficacy and Pharmacokinetic Evaluation of the Flaviviral NS5 Capping Enzyme 2-Thioxothiazolidin-4-One Inhibitor BG-323

Arthropod-borne flavivirus infection continues to cause significant morbidity and mortality worldwide. Identification of drug targets and novel antiflaviviral compounds to treat these diseases has become a global health imperative. A previous screen of 235,456 commercially available small molecules identified the 2-thioxothiazolidin-4-one family of compounds as inhibitors of the...

Subgenomic Reporter RNA System for Detection of Alphavirus Infection in Mosquitoes

Current methods for detecting real-time alphavirus (Family Togaviridae) infection in mosquitoes require the use of recombinant viruses engineered to express a visibly detectable reporter protein. These altered viruses expressing fluorescent proteins, usually from a duplicated viral subgenomic reporter, are effective at marking infection but tend to be attenuated due to the...

Analysis of RNA Binding by the Dengue Virus NS5 RNA Capping Enzyme

. Geiss 0 K.T. Jeang, National Institute of Health, United States of America 0 1 Department of Microbiology, Immunology, and Pathology, Colorado State University , Fort Collins , Colorado, United States of

Infectious alphavirus production from a simple plasmid transfection

We have developed a new method for producing infectious double subgenomic alphaviruses from plasmids transfected into mammalian cells. A double subgenomic Sindbis virus (TE3'2J) was transcribed from a cytomegalovirus PolII promoter, which results in the production of infectious virus. Transfection of as little as 125 ng of plasmid is able to produce 1 × 108 plaque forming units...

Suppression of RNA interference increases alphavirus replication and virus-associated mortality in Aedes aegypti mosquitoes

Background Arthropod-borne viruses (arboviruses) can persistently infect and cause limited damage to mosquito vectors. RNA interference (RNAi) is a mosquito antiviral response important in restricting RNA virus replication and has been shown to be active against some arboviruses. The goal of this study was to use a recombinant Sindbis virus (SINV; family Togaviridae; genus...

Actively replicating West Nile virus is resistant to cytoplasmic delivery of siRNA

Background West Nile virus is an emerging human pathogen for which specific antiviral therapy has not been developed. Recent studies have suggested that RNA interference (RNAi) has therapeutic potential as a sequence specific inhibitor of viral infection. Here, we examine the ability of exogenous small interfering RNAs (siRNAs) to block the replication of West Nile virus in human...

Recombination-ready Sindbis replicon expression vectors for transgene expression

Background Sindbis viruses have been widely used as tools to study gene function in cells. Despite the utility of these systems, the construction and production of alphavirus replicons is time consuming and inefficient due to potential additional restriction sites within the insert region and lack of directionality for insert ligation. In this report, we present a system useful...

Edelgase des Sonnenwinds in einem Aluminiumrohr von Surveyor 3

Vol. Siehe: Tritium in Lunar Material, Proc. Apollo 12 Lunar Science Conference, Geochim. Cosmochim. Acta, Suppl. II (1971), in press. 0 von P. EBERHARDT, J. GEiss, H. GRAF, 1k]-.GRt)GLER, U ... . ~RAHENBOHL, H. SCHWALLER, J. SCHWARZMOLLERund A. STETTLER (Physikalisches Institut der Universit~t Bern) 1 von P. BOCHSLER , P. EBERHARDT, J. GEiss, H. LOOSLI , H. OESCHGERund M. WAHLEN (Physikalisches

Tritium in Mondproben

Vol. Siehe: Tritium in Lunar Material, Proc. Apollo 12 Lunar Science Conference, Geochim. Cosmochim. Acta, Suppl. II (1971), in press. 0 von P. EBERHARDT, J. GEiss, H. GRAF, 1k]-.GRt)GLER, U ... . ~RAHENBOHL, H. SCHWALLER, J. SCHWARZMOLLERund A. STETTLER (Physikalisches Institut der Universit~t Bern) 1 von P. BOCHSLER , P. EBERHARDT, J. GEiss, H. LOOSLI , H. OESCHGERund M. WAHLEN (Physikalisches