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Journal peer review: a bar or bridge? An analysis of a paper’s revision history and turnaround time, and the effect on citation

Journal peer review lies at the heart of academic quality control. This article explores the journal peer review process and seeks to examine how the reviewing process might itself contribute to papers, leading them to be more highly cited and to achieve greater recognition. Our work builds on previous observations and views expressed in the literature about (a) the role of...

Challenges in finding and measuring behavioural determinants of childhood obesity in Europe

l'Aggiornamento del Personale del Servizio Sanitario (CeFPAS) , Caltanissetta , Italy 5 P. Di Mattia S. Elia Hospital , Caltanissetta , Italy 6 M. J. Rigby School of Public Policy and Professional Practice

Functional Role of Adult Hippocampal Neurogenesis as a Therapeutic Strategy for Mental Disorders

funds from Mayo foundation to M. H. Jang, and by a Summer Undergraduate Research Fellowship from Mayo Graduate School to M. J. Rigby. References R. C. Kessler, W. T. Chiu, O. Demler, K. R. Merikangas

Ultrafast Red Light Activation of Synechocystis Phytochrome Cph1 Triggers Major Structural Change to Form the Pfr Signalling-Competent State

Phytochromes are dimeric photoreceptors that regulate a range of responses in plants and microorganisms through interconversion of red light-absorbing (Pr) and far-red light-absorbing (Pfr) states. Photoconversion between these states is initiated by light-driven isomerization of a bilin cofactor, which triggers protein structural change. The extent of this change, and how light...

Use of a Molecular Decoy to Segregate Transport from Antigenicity in the FrpB Iron Transporter from Neisseria meningitidis

FrpB is an outer membrane transporter from Neisseria meningitidis, the causative agent of meningococcal meningitis. It is a member of the TonB-dependent transporter (TBDT) family and is responsible for iron uptake into the periplasm. FrpB is subject to a high degree of antigenic variation, principally through a region of hypervariable sequence exposed at the cell surface. From...

Neutrophil Extracellular Traps and Bacterial Biofilms in Middle Ear Effusion of Children with Recurrent Acute Otitis Media – A Potential Treatment Target

Background Bacteria persist within biofilms on the middle ear mucosa of children with recurrent and chronic otitis media however the mechanisms by which these develop remain to be elucidated. Biopsies can be difficult to obtain from children and their small size limits analysis. Methods In this study we aimed to investigate biofilm presence in middle ear effusion (MEE) from...

Characterisation of PduS, the pdu Metabolosome Corrin Reductase, and Evidence of Substructural Organisation within the Bacterial Microcompartment

PduS is a corrin reductase and is required for the reactivation of the cobalamin-dependent diol dehydratase. It is one component encoded within the large propanediol utilisation (pdu) operon, which is responsible for the catabolism of 1,2-propanediol within a self-assembled proteinaceous bacterial microcompartment. The enzyme is responsible for the reactivation of the cobalamin...

Bacillus megaterium Has Both a Functional BluB Protein Required for DMB Synthesis and a Related Flavoprotein That Forms a Stable Radical Species

Despite the extensive study of the biosynthesis of the complex molecule B12 (cobalamin), the mechanism by which the lower ligand 5,6-dimethylbenzimidazole (DMB) is formed has remained something of a mystery. However, recent work has identified and characterized a DMB-synthase (BluB) responsible for the oxygen-dependent, single enzyme conversion of FMN to DMB. In this work, we...

Multi-species bacterial biofilm and intracellular infection in otitis media

Background Bacteria which are metabolically active yet unable to be cultured and eradicated by antibiotic treatment are present in the middle ear effusion of children with chronic otitis media with effusion (COME) and recurrent acute otitis media (rAOM). These observations are suggestive of biofilm presence or intracellular sequestration of bacteria and may play a role in OM...

Short-Term and Medium-Term Clinical Outcomes of Quinolone-Resistant Campylobacter Infection

Background. Campylobacter species is a leading cause of bacterial gastroenteritis worldwide. Quinolone resistance has emerged as an increasing problem among persons with Campylobacter infection over the past decade, but the clinical consequences are unclear. Methods. A case-comparison study of patients infected with ciprofloxacin-resistant or ciprofloxacin-susceptible...

Confronting the Epidemic: The Need for Global Solutions

The growth in the global epidemic of obesity is fundamentally linked to economic factors. The rising prevalence of overweight and obesity has occurred during a period when the real cost of the main components of many processed foods has declined significantly, partly due to state subsidies in the protected markets of western economies. It is suggested that the vigorous promotion...

Conservation aspects of natural populations and captive-bred stocks of turbot (Scophthalmus maximus) and Dover sole (Solea solea) using estimates of genetic diversity

J. Rigby 0 Audrey J. Geffen 0 John P. Thorpe 0 0 A. Exadactylos: Department of Ichthyology and Aquatic Environment, School of Agricultural Sciences, University of Thessaly , Fytokou Street, 384 46 Nea ... Ionia Magnesias, Hellas , Greece. M. J. Rigby and J. P. Thorpe: Port Erin Marine Laboratory , School of Biological Sciences, University of Liverpool , Port Erin, Isle of Man IM9 6JA , UK. A. J. Geffen

VLA detection of OH absorption from the elliptical galaxy NGC 1052

VLA observations of OH absorption towards the elliptical galaxy NGC 1052 are presented. Both OH lines, at 1665 and 1667 MHz, were detected in absorption towards the center of NGC 1052. The hyperfine ratio of the two OH lines (τ 1667/τ 1665) is as compared to 1.8 expected for the excitation under LTE conditions for an optically thin cloud. The column density of OH is estimated to...

Sclerosing peritonitis: the experience in Australia

Background. Sclerosing peritonitis (SP) is a rare but serious complication of peritoneal dialysis (PD). Small-bowel obstruction (SBO) due to encapsulation, dense adhesions, or mural fibrous is characteristic, often associated with peritonitis. The aim of the study was to determine the incidence, clinical features, effect of duration of dialysis, and other possible aetiological...

The Use of Histone as a Facilitator to Improve the Efficiency of Retroviral Gene Transfer

Vectors based on murine C-type retroviruses are commonly used in biology. The efficiency of viral infection is normally increased by a facilitator, for example polybrene, DEAE-dextran or a liposome. The receptor for ecotropic viruses is a transporter for basic amino acids; we therefore explored the use of a highly basic protein, histone type IIA, as a facilitator. We show in...