, The NetherlandsArend Jan Nieuwland, Vivianne BC Kokje, Jaap F Hamming & Jan H N LindemanDepartment Surgery, Jeroen Bosch Ziekenhuis, Den Bosch, The NetherlandsOlivier H KoningDepartment of Molecular ... journals • PubMed • Google ScholarSearch for Jaap F Hamming in:Nature Research journals • PubMed • Google ScholarSearch for Karoly Szuhai in:Nature Research journals • PubMed • Google ScholarSearch for Frans
Background Independent of their blood pressure lowering effect, ACE inhibitors are thought to reduce vascular inflammation. The clinical relevance of this effect is unclear with the current knowledge. Abdominal aortic aneurysms (AAA) are characterized by a broad, non-specific inflammatory response, and thus provide a clinical platform to evaluate the anti-inflammatory potential...
3 Jaap F. Hamming Aart J. van der Molen Suzanne C. Cannegieter Hein Putter Wilbert B. van den Hout Inci Kilicsoy 1 Ton J. Rabelink 0 Menno V. Huisman 1 Kathrin Eller, Medizinische Universitat Graz ... inclusion of study patients. Author Contributions Conceptualization: Judith Kooiman, Yvo W. J. Sijpkens, Jaap F. Hamming, Suzanne C. Cannegieter, Menno V. Huisman. Data curation: Judith Kooiman, Jean-Paul
Surgical training in the Netherlands has traditionally been characterized by learning on the job under the classic master-trainee doctrine. Over the past decades, it has become regionally organized with intensive structural training courses, and a peer-based quality control system. Recently, the nationwide programme has been modernized further and now involves a systematic...
The current study describes the incidence and phenotype of plaque rupture complications in murine vein grafts. Since matrix metalloproteinases (MMPs) are highly involved in atherosclerotic plaque vulnerability and plaque rupture, we hypothesized that this model can be validated by overexpression of the MMP inhibitor TIMP-1. First we studied 47 vein grafts in hypercholesterolemic...
Objectives Units deployed to armed conflicts are at high risk for exposure to combat events. Many battle casualties (BCs) have been reported in the recent deployment to Afghanistan. The long-term impact of these combat injuries, at their five-year end point, is currently unknown. To date, no systematic inventory has been performed of an identified group of BCs in comparison to...
Background Acute appendicitis continues to be a challenging diagnosis. Preoperative radiological imaging using ultrasound (US) or computed tomography (CT) has gained popularity as it may offer a more accurate diagnosis than classic clinical evaluation. The optimal implementation of these diagnostic modalities has yet to be established. The aim of the present study was to...
BackgroundThe aim of the present study was to investigate the efficacy and safety of standard outpatient re-evaluation for patients who are not admitted to the hospital after emergency department surgical consultation for acute abdominal pain.MethodsAll patients seen at the emergency department between June 2005 and July 2006 for acute abdominal pain were included in a...
Hes Bernadette TJ van Brussel Eleonora PM Corssmit Jaap F Hamming Andel GL van der Mey Jeroen C Jansen Hereditary paraganglioma is a benign tumor syndrome with an age-dependent penetrance. Carriers of
Background Guidelines recommend saline hydration for prophylaxis of contrast-induced acute kidney injury (CI-AKI) in patients with chronic kidney disease (CKD) undergoing intravenous contrast media-enhanced CT (CE-CT). The safety and efficacy of a brief hydration protocol using sodium bicarbonate in this population is unknown. We analysed whether 1-h sodium bicarbonate hydration...
Aims We investigated the role of the TLR4-accessory molecule RP105 (CD180) in post-ischemic neovascularization, i.e. arteriogenesis and angiogenesis. TLR4-mediated activation of pro-inflammatory Ly6Chi monocytes is crucial for effective neovascularization. Immunohistochemical analyses revealed that RP105+ monocytes are present in the perivascular space of remodeling collateral...
Aims In collateral development (i.e. arteriogenesis), mononuclear cells are important and exist as a heterogeneous population consisting of pro-inflammatory and anti-inflammatory/repair-associated cells. Protease-activated receptor (PAR)1 and PAR2 are G-protein-coupled receptors that are both expressed by mononuclear cells and are involved in pro-inflammatory reactions, while...
Background Multiple endocrine neoplasia type 2 (MEN 2) is caused by a RET mutation in chromosome 10. All MEN 2 patients develop medullary thyroid carcinoma (MTC). The age-related risk of MTC is associated with the type of RET mutation. Our aim was to identify prognostic factors associated with recurrent MTC in MEN 2 patients. Methods In a nationwide case–control study, all...
