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Unexpected and striking effect of heparin-free dialysis on cytokine release

Heparin (both unfractionated and low molecular weight) is not only a potent anticoagulant but also has many pleiotropic effects, some of which are mediated by cytokine release. We compared the effect of hemodialysis (HD) with enoxaparin as an anticoagulant and without systemic anticoagulation (heparin-grafted membrane—Evodial) on the release of monocyte chemoattractant protein 1...

Liver disease vs systemic inflammation in haemodialysis patients

importance in maintenance HD patients. Further studies are needed before this new trait is definitely excluded. Medical University Bialystok Poland Email: Jacek Borawski Beata Naumnik Michal Mys liwiec

Enoxaparin but not unfractionated heparin causes a dose-dependent increase in plasma TGF-β1 during haemodialysis: a cross-over study

Background. Transforming growth factor-β1 (TGF-β1) is a multi-functional cytokine that presents as a mediator of the heparin's pleiotropic action. In this cross-over study, we compared the effects of enoxaparin and unfractionated heparin (UFH) used as anticoagulants during haemodialysis (HD) on plasma TGF-β1 levels and some platelet activation markers: platelet-derived growth...

The periodontal status of pre-dialysis chronic kidney disease and maintenance dialysis patients

Background. Periodontitis contributes to generalized inflammation and development of systemic diseases, including atherosclerosis and cardiovascular disease. Its extent in maintenance haemodialysis (HD) patients is disputable and not known in continuous ambulatory peritoneal dialysis (CAPD) and pre-dialysis chronic kidney disease (CKD) patients. Methods. One hundred and six...

Tissue factor and its inhibitor in human non-crescentic glomerulonephritis—immunostaining vs plasma and urinary levels

Background. Tissue factor (TF)—the most potent trigger of coagulation and emerging antiapoptotic, proliferative and angiogenic factor, along with its principal inhibitor (tissue factor pathway inhibitor, TFPI) are known to be involved in crescentic glomerulonephritis (GN). We studied the relationship between plasma and urinary levels as well as renal biopsy immunostaining of TF...

Striking increase in circulating hepatocyte growth factor during enoxaparin-anticoagulated haemodialysis

Bialystok, Poland Email: Jacek Borawski Beata Naumnik Michal Mys´ liwiec 1. Borawski J, Mysliwiec M. Serum hepatocyte growth factor is associated with viral hepatitis, cardiovascular disease

Different effects of enoxaparin and unfractionated heparin on extrinsic blood coagulation during haemodialysis: a prospective study

Background. Heparin inhibits prothrombotic tissue factor (TF) and releases its inhibitor, tissue factor pathway inhibitor (TFPI), from the endothelium, but repeated administration of heparin depletes vascular stores of TFPI. We studied the anticoagulant effects of unfractionated heparin (UFH) vs low‐molecular‐weight enoxaparin—used for thrice‐weekly maintenance haemodialysis (HD...

Pathophysiology CKD 5D

Introduction and Aims: Previous studies have shown that the prevalence of depression is high in patients with chronic kidney disease (CKD). Depression is associated with increased cardiovascular mortality and the higher rate of suicides in these patients. However, up to now, there is no data concerning the prevalence of depression in haemodialyzed patients in Poland. The aim of...