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The Dkk3 gene encodes a vital intracellular regulator of cell proliferation

DKK1, DKK2 and DKK4 bind to the LRP5/6 and Kremen subunits of the receptor [ 5 ] and prevent assembly of a functional Wnt receptor complex [6±8]. The following competing interests: Jack L. Leonard ... , Deborah M. Leonard and Karl J. Simin and the University of Massachusetts Medical School have a patent pending PCT/US2013/031118 entitled ªAntitumor Properties of Dickkopf 3bº; Jack L. Leonard claims