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Treatment of localized gastric and gastroesophageal adenocarcinoma: the role of accurate staging and preoperative therapy

Das 2 Jaffer Ajani 1 0 Department of Surgical Oncology, The University of Texas, Unit 1484, MD Anderson Cancer Center , 1515 Holcombe Blvd., Houston, TX 77030 , USA 1 Departments of Gastrointestinal

Lessons learned from a phase II clinical trial of laparoscopic HIPEC for gastric cancer

Background Over the last two decades, intraperitoneal chemotherapy has been found to have activity for select subgroups of patients with carcinomatosis from colon, ovarian, appendiceal, and recently, gastric origins. However, there is little data to support an aggressive surgical approach of cytoreduction (debulking) and hyperthermic intraperitoneal perfusion with chemotherapy ...

Genome-wide methylation analysis shows similar patterns in Barrett’s esophagus and esophageal adenocarcinoma

Barrett’s esophagus (BE) is a precursor of esophageal adenocarcinoma (EAC). To identify novel tumor suppressors involved in esophageal carcinogenesis and potential biomarkers for the malignant progression of BE, we performed a genome-wide methylation profiling of BE and EAC tissues. Using Illumina’s Infinium HumanMethylation27 BeadChip microarray, we examined the methylation status ...

Octreotide Acetate in Prevention of Chemoradiation-Induced Diarrhea in Anorectal Cancer: Randomized RTOG Trial 0315

Background In anorectal cancer patients, an acute side effect of chemoradiotherapy is gastrointestinal toxicity, which often impedes treatment delivery. Based on previous trials, octreotide acetate is widely recommended for the control of chemotherapy-induced diarrhea. However, the effectiveness of octreotide in preventing or controlling radiation- and chemoradiation-induced ...

Molecular basis of gastric cancer development and progression

Gastric cancer is one of the leading causes of cancer death worldwide. Because of its heterogeneity, gastric cancer has been an interesting model for studying carcinogenesis and tumorigenesis. Various genetic and molecular alterations are found in gastric cancer that underlie the malignant transformation of gastric mucosa during the multistep process of gastric cancer pathogenesis. ...

Poster discussions

Introduction The purpose of the present study was to examine the prevalence of sexual dysfunction in newly diagnosed sexually active colorectal cancer female patients prior to treatment and identify the characteristics and correlates of dysfunction.