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Search: authors:"Jaffer Ajani"

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Genome-wide methylation analysis shows similar patterns in Barrett’s esophagus and esophageal adenocarcinoma

Barrett’s esophagus (BE) is a precursor of esophageal adenocarcinoma (EAC). To identify novel tumor suppressors involved in esophageal carcinogenesis and potential biomarkers for the malignant progression of BE, we performed a genome-wide methylation profiling of BE and EAC tissues. Using Illumina’s Infinium HumanMethylation27 BeadChip microarray, we examined the methylation status ...

Octreotide Acetate in Prevention of Chemoradiation-Induced Diarrhea in Anorectal Cancer: Randomized RTOG Trial 0315

Background In anorectal cancer patients, an acute side effect of chemoradiotherapy is gastrointestinal toxicity, which often impedes treatment delivery. Based on previous trials, octreotide acetate is widely recommended for the control of chemotherapy-induced diarrhea. However, the effectiveness of octreotide in preventing or controlling radiation- and chemoradiation-induced ...

Poster discussions

Introduction The purpose of the present study was to examine the prevalence of sexual dysfunction in newly diagnosed sexually active colorectal cancer female patients prior to treatment and identify the characteristics and correlates of dysfunction.