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Antioxidants in the Fight Against Atherosclerosis: Is This a Dead End?

Nacional Autónoma de México , Mexico City , Mexico 1 Jaime Mas-Oliva Purpose of Review The purpose of this review is to focus on the outcome of recent antioxidant interventions using synthetic and ... degenerative diseases. Compliance with Ethical Standards Conflict of Interest Paola Toledo-Ibelles and Jaime Mas-Oliva declare no conflict of interest. Studies by J.M-O research group described in this review

Early Transcriptomic Response to LDL and oxLDL in Human Vascular Smooth Muscle Cells

Background Although nowadays it is well known that the human transcriptome can importantly vary according to external or environmental condition, the reflection of this concept when studying oxidative stress and its direct relationship with gene expression profiling during the process of atherogenesis has not been thoroughly achieved. Objective The ability to analyze genome-wide...

ARP2, a Novel Pro-Apoptotic Protein Expressed in Epithelial Prostate Cancer LNCaP Cells and Epithelial Ovary CHO Transformed Cells

- Funding: This work was supported by CONACyT (Grant 141588) and DGAPA-UNAM (Grant IN-205711/2) awarded to Jaime Mas-Oliva. Enrique Navarro-Vidal was supported by scholarships from Consejo Nacional de Ciencia

Microenvironmentally controlled secondary structure motifs of apolipoprotein A-I derived peptides

The structure of apolipoprotein A-I (apoA-I), the major protein of HDL, has been extensively studied in past years. Nevertheless, its corresponding three-dimensional structure has been difficult to obtain due to the frequent conformational changes observed depending on the microenvironment. Although the function of each helical segment of this protein remains unclear, it has been...

The Hemorrhagic Coli Pilus (HCP) of Escherichia coli O157:H7 Is an Inducer of Proinflammatory Cytokine Secretion in Intestinal Epithelial Cells

Background Enterohemorrhagic Escherichia coli (EHEC) O157:H7, the causative agent of hemorrhagic colitis and the hemolytic uremic syndrome (HUS), produces long bundles of type IV pili (TFP) called hemorrhagic coli pili (HCP). HCP are capable of mediating several phenomena associated with pathogenicity: i) adherence to human and bovine epithelial cells; ii) invasion of epithelial...