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Pertussis in Young Infants Throughout the World

any medium, provided the original work is properly cited. DOI: 10.1093/cid/ciw550 1 James D. Cherry Department of Pediatrics, David Geffen School of Medicine, University of California , Los Angeles In

Effectiveness of Prenatal Tetanus, Diphtheria, and Acellular Pertussis Vaccination on Pertussis Severity in Infants

Background. All US women are recommended to receive a tetanus, diphtheria, and acellular pertussis (Tdap) vaccine at 27–36 weeks gestation during each pregnancy to reduce the risk of pertussis to their infants. The impact of this strategy on severity of disease among infected infants has not been evaluated. Methods. We use a retrospective cohort study design evaluating whether...

The History of Pertussis (Whooping Cough); 1906–2015: Facts, Myths, and Misconceptions

, 10833 Le Conte Avenue, MDCC 22-442, Los Angeles, CA 90095-1972 , USA 1 James D. Cherry Pertussis and Bordetella pertussis infections since 1906 are reviewed with an attempt to address facts, myths, and

The Present and Future Control of Pertussis

James D. Cherry () 0 0 Department of Pediatrics, David Geffen School of Medicine at University of California-Los Angeles (UCLA), and Division of Pediatric Infectious Diseases, Mattel Children's

Patterns of Bordetella parapertussis Respiratory Illnesses: 2008–2010

Clinical specimens from 9 states during 2008–2010 were tested by PCR for Bordetella pertussis and Bordetella parapertussis. Of the positive samples, 13.99% were identified as B. parapertussis. It was concluded that B. parapertussis infections are more common than previously realized and contribute to cases thought to be vaccine failures.

Immunity to Pertussis

James D. Cherry () 0 0 Department of Pediatrics, David Geffen School of Medicine at UCLA, and Division of Infectious Diseases, Mattel Children's Hospital at UCLA , Los Angeles, California

The Protein Content of Diphtheria-Tetanus Toxoids–Acellular Pertussis Vaccines and an Emerging Clinical Problem

previous 2 decades is reassuring in this regard. My suggestions would, of course, need to be evaluated in James D. Cherry Department of Pediatrics, David Geffen School of Medicine at UCLA, and Division of

Clinical Definitions of Pertussis: Summary of a Global Pertussis Initiative Roundtable Meeting, February 2011

Existing clinical case definitions of pertussis are decades old and based largely on clinical presentation in infants and children, yet an increasing burden is borne by adolescents and adults who may manifest distinct signs/symptoms. Therefore, a “one-size-fits-all” clinical case definition is no longer appropriate. Seeking to improve pertussis diagnosis, the Global Pertussis...

Pertussis in the Preantibiotic and Prevaccine Era, with Emphasis on Adult Pertussis

James D. Cherry () 0 0 From the Department of Pediatrics and the UCLA Center for Vaccine Research, UCLA School of Medicine , Los Angeles, California Pertussis was first recognized as an epidemic

Epidemiological, Clinical, and Laboratory Aspects of Pertussis in Adults

In populations without immunization, pertussis is a high-incidence, endemic disease with cyclic epidemic peaks occurring every 2–5 years. The universal use of pertussis vaccines in children results in a marked reduction in incidence, but the frequency of disease cycles does not lengthen. This indicates that the organism (Bordetella pertussis) remains prevalent in the population...

Evidence of Bordetella pertussis infection in vaccinated 1-year-old Danish children

laboratory studies in this paper were supported by an unrestricted grant from Sanofi pasteur. Carl-Heinz Wirsing von Knig and James D. Cherry have been consultants to Sanofi pasteur and have been participants

Serologic Response and Antibody-Titer Decay in Adults with Pertussis

Pertussis is a frequent and significant illness in adults. Because acellular pertussis vaccines for use in adolescents and adults have now been developed, it is important to compare serologic responses in adults after infection with serologic responses in adults after vaccination. We measured IgG and IgA antibodies to 4 Bordetella pertussis antigens at ∼6-month intervals for 28...

Historical Review Of Pertussis And The Classical Vaccine

The Journal of Infectious Diseases 1996 Historical Review o f Pertussis and the Classical Vaccine James D. Cherry 0 1 0 Financial support: Lederle-Praxis Biologicals; NIH (AJ-15124). UCLA School of

Determination of Serum Antibody to Bordetella pertussis Adenylate Cyclase Toxin in Vaccinated and Unvaccinated Children and in Children and Adults with Pertussis

Presence of antibody to adenylate cyclase toxin (ACT) has been noted following Bordetella pertussis infection. Because ACT is not presently in any acellular pertussis vaccines, it has been considered as a possible antigen to use in B. pertussis diagnostic enzyme-linked immunosorbent assay (ELISA) studies. We determined antibody to B. pertussis ACT by ELISA and Western blot tests...

Evidence of Efficacy of the Lederle/Takeda Acellular Pertussis Component Diphtheria and Tetanus Toxoids and Pertussis Vaccine but Not the Lederle Whole-Cell Component Diphtheria and Tetanus Toxoids and Pertussis Vaccine Against Bordetella parapertussis Infection

A subanalysis of a recent cohort efficacy trial of a pertussis vaccine was performed to determine its efficacy against cough illnesses due to Bordetella parapertussis infections. Infants received four doses of either the Lederle/Takeda acellular pertussis component diphtheria and tetanus toxoids and pertussis (DTaP) vaccine or the Lederle whole-cell component diphtheria and...

Frequency of Serological Evidence of Bordetella Infections and Mixed Infections with other Respiratory Pathogens in University Students with Cough Illnesses

Banked acute-phase and convalescent-phase serum samples from a previous study of respiratory illness in university students were examined for significant (≥2-fold) increases in ELISA titers of IgA and IgG antibody to Bordetella pertussis filamentous hemagglutinin, pertactin, and fimbriae-2 and ≥4-fold titer increases to agglutinogens by agglutination. ELISA titers of antibody to...

Bordetella Pertussis Infections in Vaccinated and Unvaccinated Adolescents and Adults, as Assessed in a National Prospective Randomized Acellular Pertussis Vaccine Trial (APERT)

Background. Acellular pertussis (aP) booster immunizations have been recommended for adolescents and older persons to enhance long-term protection and to possibly reduce community transmission of infections. Methods. This was a multicenter, randomized, double-blind vaccine trial in which one-half of the subjects received aP vaccine and one-half received hepatitis A vaccine...

Pathology and Pathogenesis of Fatal Bordetella pertussis Infection in Infants

Background. Each year, Bordetella pertussis infection causes an estimated 294,000 deaths worldwide, primarily among young, nonvaccinated children. Approximately 90% of all deaths due to pertussis in the Unites States occur in young infants. These children often develop intractable pulmonary hypertension; however, the pathophysiologic mechanism responsible for this complication...