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67 papers found.
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Transethnic insight into the genetics of glycaemic traits: fine-mapping results from the Population Architecture using Genomics and Epidemiology (PAGE) consortium

Aims/hypothesis Elevated levels of fasting glucose and fasting insulin in non-diabetic individuals are markers of dysregulation of glucose metabolism and are strong risk factors for type 2 diabetes. Genome-wide association studies have discovered over 50 SNPs associated with these traits. Most of these loci were discovered in European populations and have not been tested in a ...

Cerebral white matter hyperintensities on MRI and acceleration of epigenetic aging: the atherosclerosis risk in communities study

Background Cerebral white matter hyperintensities (WMH) on magnetic resonance imaging (MRI) are part of the spectrum of brain vascular injury accompanying aging and are associated with a substantial risk of stroke and dementia. We investigated the association of cerebral WMH burden on MRI with a DNA methylation-based biomarker of aging, termed DNA methylation age acceleration, ...

Genome-Wide Interaction with Insulin Secretion Loci Reveals Novel Loci for Type 2 Diabetes in African Americans

Type 2 diabetes (T2D) is the result of metabolic defects in insulin secretion and insulin sensitivity, yet most T2D loci identified to date influence insulin secretion. We hypothesized that T2D loci, particularly those affecting insulin sensitivity, can be identified through interaction with insulin secretion loci. To test this hypothesis, single nucleotide polymorphisms (SNPs) ...

A genetic association study of activated partial thromboplastin time in European Americans and African Americans: the ARIC Study

Reduced activated partial thromboplastin time (aPTT) is a risk marker for incident and recurrent venous thromboembolism (VTE). Genetic factors influencing aPTT are not well understood, especially in populations of non-European ancestry. The present study aimed to identify aPTT-related gene variants in both European Americans (EAs) and African Americans (AAs). We conducted a genetic ...

Interaction between the NOS3 Gene and Obesity as a Determinant of Risk of Type 2 Diabetes: The Atherosclerosis Risk in Communities Study

Endothelial nitric oxide synthase 3 (NOS3) catalyzes the production of nitric oxide from L-arginine in endothelial cells. Obesity is a modifiable risk factor for diabetes, and obese individuals have been reported to have reduced nitric oxide availability compared to controls whose weight is in the normal range. Since homozygous carriers of the NOS3 G894T variant are predicted to ...

Genetics of Plasma Soluble Receptor for Advanced Glycation End-Products and Cardiovascular Outcomes in a Community-based Population: Results from the Atherosclerosis Risk in Communities Study

Plasma soluble Receptor for Advanced Glycation End-products (sRAGE) is a strong marker of vascular outcomes although evidence on the direction of association is mixed. Compared to whites, blacks have lower levels of sRAGE. We hypothesized that genetic determinants of sRAGE would help clarify the causal role of sRAGE and the black-white difference in sRAGE levels. We conducted a ...

Association of Lipid-Related Genetic Variants with the Incidence of Atrial Fibrillation: The AFGen Consortium

Background Several studies have shown associations between blood lipid levels and the risk of atrial fibrillation (AF). To test the potential effect of blood lipids with AF risk, we assessed whether previously developed lipid gene scores, used as instrumental variables, are associated with the incidence of AF in 7 large cohorts. Methods We analyzed 64,901 individuals of European ...

Temporal Relationship Between Uric Acid Concentration and Risk of Diabetes in a Community-based Study Population

(Janet W. Maynard); and Divi- sion of Epidemiology and Community Health, School of Public Health, University of Minnesota , Minneapolis , Minne- sota (James S. Pankow). The Atherosclerosis Risk in

Chronic inflammation role in the obesity-diabetes association: a case-cohort study

Background Chronic inflammation is related to both obesity and diabetes. Our aim was to investigate to what extent this inflammation contributes to the association between obesity and diabetes. Methods Using a case-cohort design, we followed 567 middle-aged individuals who developed diabetes and 554 who did not over 9 years within the ARIC Study. Weighted Cox proportional hazards ...

Validity and Reliability of Self-reported Diabetes in the Atherosclerosis Risk in Communities Study

Andrea L. C. Schneider James S. Pankow Gerardo Heiss Elizabeth Selvin Correspondence to Andrea L. C. Schneider East Monument Street Suite Baltimore (e-mail: ). American Journal of Epidemiology The ... , Minneapolis, Minnesota (James S. Pankow); and Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (Gerardo Heiss). The

Epigenome-wide association study (EWAS) of BMI, BMI change and waist circumference in African American adults identifies multiple replicated loci

Liming Liang 5 17 18 Chunyu Liu 6 17 Jan Bressler 12 Tim D. Spector 2 Kari North 4 Yun Li 1 3 11 Devin M. Absher 0 Daniel Levy 17 18 Donna K. Arnett 20 Myriam Fornage 12 13 James S. Pankow 15 Eric

Evaluation of microarray-based DNA methylation measurement using technical replicates: the Atherosclerosis Risk In Communities (ARIC) Study

Background DNA methylation is a widely studied epigenetic phenomenon; alterations in methylation patterns influence human phenotypes and risk of disease. As part of the Atherosclerosis Risk in Communities (ARIC) study, the Illumina Infinium HumanMethylation450 (HM450) BeadChip was used to measure DNA methylation in peripheral blood obtained from ~3000 African American study ...

Factors Related to Fungiform Papillae Density: The Beaver Dam Offspring Study

The distribution of fungiform papillae density and associated factors were examined in the Beaver Dam Offspring Study. Data were from 2371 participants (mean age = 48.8 years, range = 21–84 years) with 1108 males and 1263 females. Fungiform papillae were highlighted with blue food coloring and the number of fungiform papillae within a standard 6-mm circle was counted. Whole mouth ...

Novel Risk Factors and the Prediction of Type 2 Diabetes in the Atherosclerosis Risk in Communities (ARIC) Study

L.A. RAYNOR PHD JAMES S. PANKOW PHD BRUCE B. DUNCAN PHD MARIA I. SCHMIDT PHD RON C. HOOGEVEEN PHD MARK A. PEREIRA PHD J. HUNTER YOUNG CHRISTIE M. BALLANTYNE E p i d e m i o l o g y / H e a l t h

Does Genetic Ancestry Explain Higher Values of Glycated Hemoglobin in African Americans?

Nisa M. Maruthur W.H. Linda Kao Jeanne M. Clark Frederick L. Brancati Ching-Yu Cheng James S. Pankow Elizabeth Selvin RESEARCH DESIGN AND METHODS-We performed a cross-sectional analysis of data

Racial Differences in Association of Elevated Interleukin-18 Levels With Type 2 Diabetes: The Atherosclerosis Risk in Communities Study

Differences in Association of Elevated Interleukin-18 Levels With Type 2 Diabetes SMITA I. NEGI JAMES S. PANKOW KARL FERNSTROM RON C. HOOGEVEEN NA ZHU DAVID COUPER MARIA I. SCHMIDT BRUCE B. DUNCAN CHRISTIE M

Risk of Type 2 Diabetes and Obesity Is Differentially Associated with Variation in FTO in Whites and African-Americans in the ARIC Study

Single nucleotide polymorphisms (SNPs) in the fat mass and obesity associated (FTO) gene are associated with body mass index (BMI) in populations of European descent. The FTO rs9939609 variant, first detected in a genome-wide association study of diabetes, conferred an increased disease risk that was abolished after adjustment for BMI, suggesting that the association may be due to ...

Olfactory Impairment in an Adult Population: The Beaver Dam Offspring Study*

The objective of this study was to determine the prevalence of olfactory impairment and associated risk factors and the effects of olfactory impairment on dietary choices and quality of life. Odor identification was measured in 2838 participants aged 21–84 years (mean 49 years) in the Beaver Dam Offspring Study. The overall prevalence of olfactory impairment was 3.8%, increased ...

Strength of Association for Incident Diabetes Risk Factors According to Diabetes Case Definitions: The Atherosclerosis Risk in Communities Study

Community Health, University of Minnesota School of Public Health, Minneapolis, Minnesota (James S. Pankow); Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago

Lactate and Risk of Incident Diabetes in a Case-Cohort of the Atherosclerosis Risk in Communities (ARIC) Study

Background Oxidative capacity is decreased in type 2 diabetes. Whether decreased oxidative capacity is a cause or consequence of diabetes is unknown. Our purpose is to evaluate whether lactate, a marker of oxidative capacity, is associated with incident diabetes. Methods and Findings We conducted a case-cohort study in the Atherosclerosis Risk in Communities (ARIC) study at year 9 ...