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Fundamentals of and Critical Issues in Lipid Autacoid Medicine: A Review

The identification of a number of families of lipid signal molecules since the 1990s created new therapeutic possibilities for a great number of disorders characterized by chronic inflammation and pain. These lipid autacoids have been explored in a great variety of animal models related to inflammation, pain, (neuro-)protection, and repair. Based on the data from these models, as...

Phenytoin and carbamazepine in trigeminal neuralgia: marketing-based versus evidence-based treatment

Phenytoin and carbamazepine in trigeminal neuralgia: marketing-based versus evidence-based treatment Jan M Keppel Hesselink,1 Michael E Schatman2,3 1Institute for Neuropathic Pain, Bosch en Duin, the

Topical phenytoin for the treatment of neuropathic pain

Topical phenytoin for the treatment of neuropathic pain David J Kopsky,1 Jan M Keppel Hesselink2 1Institute for Neuropathic Pain, Amsterdam, 2Institute for Neuropathic Pain, Bosch en Duin, the Netherlands Abstract: We developed and tested a new putative analgesic cream, based on the anticonvulsant phenytoin in patients suffering from treatment refractory neuropathic pain. The use...

Bottlenecks in the development of topical analgesics: molecule, formulation, dose-finding, and phase III design

Bottlenecks in the development of topical analgesics: molecule, formulation, dose-finding, and phase III design Jan M Keppel Hesselink,1 David J Kopsky,2 Stephen M Stahl3 1Institute Neuropathic Pain

Resolvins and aliamides: lipid autacoids in ophthalmology – what promise do they hold?

Resolvins and aliamides: lipid autacoids in ophthalmology – what promise do they hold? Jan M Keppel Hesselink,1 Flavia Chiosi,2 Ciro Costagliola2 1University of Witten/Herdecke, Witten, Germany; 2Eye

Palmitoylethanolamide, a neutraceutical, in nerve compression syndromes: efficacy and safety in sciatic pain and carpal tunnel syndrome

Palmitoylethanolamide, a neutraceutical, in nerve compression syndromes: efficacy and safety in sciatic pain and carpal tunnel syndrome Jan M Keppel Hesselink, David J KopskyInstitute for Neuropathic

Walking with Neuropathic Pain: Paradoxical Shift from Burden to Support?

Baclofen 5% cream can be used for the treatment of neuropathic pain. We describe an unusual case of a neuropathic pain patient with spinal cord injury. A 71-year-old woman with a partial spinal cord injury lesion at L4 complained of tingling, pins and needles, and burning in her legs. She scored her pain as 6 before adding baclofen 5% cream to her pain medication (pregabalin 450...

Evolution in pharmacologic thinking around the natural analgesic palmitoylethanolamide: from nonspecific resistance to PPAR-α agonist and effective nutraceutical

Evolution in pharmacologic thinking around the natural analgesic palmitoylethanolamide: from nonspecific resistance to PPAR-α agonist and effective nutraceutical Jan M Keppel Hesselink Department of ... Keppel Hesselink 0 0 Department of Pharmacology, University of witten/Herdecke , witten , Germany The history of development of new concepts in pharmacology is a highly interesting topic. This review

Treatment of chronic regional pain syndrome type 1 with palmitoylethanolamide and topical ketamine cream: modulation of nonneuronal cells

Treatment of chronic regional pain syndrome type 1 with palmitoylethanolamide and topical ketamine cream: modulation of nonneuronal cells Jan M Keppel Hesselink,1 David J Kopsky21Institute for

Therapeutic utility of palmitoylethanolamide in the treatment of neuropathic pain associated with various pathological conditions: a case series

Therapeutic utility of palmitoylethanolamide in the treatment of neuropathic pain associated with various pathological conditions: a case series Jan M Keppel Hesselink, Thecla AM HekkerInstitute for

Central Neuropathic Pain in a Patient with Multiple Sclerosis Treated Successfully with Topical Amitriptyline

Central neuropathic pain in patients with multiple sclerosis (MS) is a common debilitating symptom, which is mostly treated with tricyclic antidepressants or antiepileptics. Unfortunately, the use of these drugs is often limited due to adverse events. We investigated the analgesic effect of topical amitriptyline 5% and 10% cream in a patient with central neuropathic pain due to...

Multimodal Stepped Care Approach Involving Topical Analgesics for Severe Intractable Neuropathic Pain in CRPS Type 1: A Case Report

: Stephen P. Peters Copyright © 2011 David J. Kopsky and Jan M. Keppel Hesselink. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use