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Polymorphisms in PARK2 and MRPL37 are associated with higher risk of recurrent venous thromboembolism in a sex-specific manner

to Dr. Bengt Zöller and Dr. Kristina Sundquist by the Swedish Research Council, and grants awarded to Dr. Jan Sundquist by King Gustaf V and Queen Victoria’s Foundation of Freemasons. Compliance with

Upper secondary school students’ compliance with two Internet-based self-help programmes: a randomised controlled trial

corresponding author states that there is no conflict of interest. Funding The Swedish Research Council for Health, Working Life, and Welfare (In Swedish: Forte) and the Swedish Research Council to Jan Sundquist

Family history of venous thromboembolism and mortality after venous thromboembolism: a Swedish population-based cohort study

to Dr Jan Sundquist by King Gustaf V and Queen Victoria’s Foundation of Freemasons. The funders had no role in study design; in the collection, analysis, and interpretation of data; in the writing of

Association between TLR9 rs5743836 polymorphism and risk of recurrent venous thromboembolism

Recent gene knockout studies on mice have shown the role of toll-like receptor 9 (TLR9) in resolution of venous thromboembolism (VTE) through sterile inflammation. However, the role of a putative functional TLR9 polymorphism (rs5743836) in risk assessment of VTE recurrence remains unknown. The aim of our study was to investigate the TLR9 rs5743836 polymorphism in VTE patients and...

Association between antithrombotic treatment and hemorrhagic stroke in patients with atrial fibrillation—a cohort study in primary care

balanced. Acknowledgments This work was supported by grants to Kristina Sundquist and Jan Sundquist from the Swedish Research Council (K2012-70X-15428-08-3) as well as ALF funding (88009) to Jan Sundquist

Gout in immigrant groups: a cohort study in Sweden

might need to be tailored for specific groups. Acknowledgements This project was supported by grants to Kristina Sundquist and Jan Sundquist from the Swedish Research Council for Health, Working Life and ... Wändell, Axel C Carlsson and Xinjun Li. Access to data: Xinjun Li, Jan Sundquist and Kristina Sundquist. Statistical analysis: Xinjun Li. Drafting of manuscript: Per Wändell. Reading and commenting

Stress resilience and subsequent risk of type 2 diabetes in 1.5 million young men

Aims/hypothesis Psychosocial stress in adulthood is associated with a higher risk of type 2 diabetes, possibly mediated by behavioural and physiological factors. However, it is unknown whether low stress resilience earlier in life is related to subsequent development of type 2 diabetes. We examined whether low stress resilience in late adolescence is associated with an increased...

Indication for pharmacological treatment is often lacking: a cross-sectional study on the quality of drug therapy among the elderly

Background Although the elderly have a substantially higher drug use than younger patients, even after adjustment for multimorbidity, there is limited knowledge about the elderly’s indication for treatment. It is essential for elderly patients to have a well-planned drug therapy. The first step towards a correct and safe drug therapy is to ensure that the patient’s drugs have an...

Women’s health in the Lund area (WHILA) - Alcohol consumption and all-cause mortality among women – a 17 year follow-up study

ALF funding from Region Skåne awarded to Patrik Midlöv, Jan Sundquist and Kristina Sundquist as well as The Swedish Research Council for Health, Working Life and Welfare (In Swedish: Forte; 2013

Autism and attention-deficit/hyperactivity disorder among individuals with a family history of alcohol use disorders

Recent studies suggest de novo mutations may involve the pathogenesis of autism and attention-deficit/hyperactivity disorder (ADHD). Based on the evidence that excessive alcohol consumption may be associated with an increased rate of de novo mutations in germ cells (sperms or eggs), we examine here whether the risks of autism and ADHD are increased among individuals with a family...

Circulating microRNA-144-5p is associated with depressive disorders

by the Swedish Research Council and FORTE to Jan Sundquist, the Swedish Research Council to KS (K2012-70X-15428-08-3), as well as the ALF funding from the Region Skåne awarded to JS and KS. We would

Can gender difference in prescription drug use be explained by gender-related morbidity?: a study on a Swedish population during 2006

Background It has been reported that there is a difference in drug prescription between males and females. Even after adjustment for multi-morbidity, females tend to use more prescription drugs compared to males. In this study, we wanted to analyse whether the gender difference in drug treatment could be explained by gender-related morbidity. Methods Data was collected on all...

The longitudinal exercise trend among older Swedes aged 53–84 years – a 16-year follow-up study

Sundquist by the Swedish Research Council and to Dr Jan Sundquist by the Swedish Council for Working Life and Social Research and the Swedish Freemasons Foundation, as well as by ALF funding from Region Skne ... awarded to Jan Sundquist and Kristina Sundquist. We are indebted to Stephen Gilliver for his expertise and invaluable advice in editing the manuscript. 1. Vaupel JW : Biodemography of human ageing . Nature

Statin use and risk of depression: a Swedish national cohort study

Grant/Research support from Eli Lilly, Pfizer, The University of Melbourne, Deakin University and the NHMRC. Cassie Redlich, Jan Sundquist, Kristina Sundquist and Xinjun Li have no conflicts of interest

Drugs prescribed by general practitioners according to age, gender and socioeconomic status after adjustment for multimorbidity level

Background Age, gender and socioeconomic status have been shown to be associated with the use of prescription drugs, even after adjustment for multimorbidity. General practitioners have a holistic and patient-centred perspective and our hypothesis is that this may reflect on the prescription of drugs. In Sweden the patient may seek secondary care without a letter of referral and...

Familial Risks of Kidney Failure in Sweden: A Nationwide Family Study

Background The value of family history as a risk factor for kidney failure has not been determined in a nationwide setting. Aim This nationwide family study aimed to determine familial risks for kidney failure in Sweden. Methods The Swedish multi-generation register on 0–78-year-old subjects were linked to the Swedish patient register and the Cause of death register for 1987–2010...

Immigrant enclaves and risk of diabetes: a prospective study

Background The diversity of the Swedish population has increased substantially over the past three decades. The aim of this study was to assess whether living in an ethnic enclave is associated with risk of diabetes mellitus (DM) among first and second-generation immigrants and native Swedes. Methods Cumulative incidence of DM in three urban municipalities was assessed from 2006...

Incidence of hereditary amyloidosis and autoinflammatory diseases in Sweden: endemic and imported diseases

Background Amyloidoses are a heterogeneous group of progressive diseases caused by tissue deposition of misfolded proteins. According to the International Classification of Diseases, hereditary amyloidosis is divided into neuropathic and non-neuropathic forms. In Sweden, neuropathic heredofamilial amyloidosis has been identified as familial amyloidotic polyneuropathy (FAP), a...

Digested wheat gluten inhibits binding between leptin and its receptor

Background Leptin resistance is considered a primary risk factor for obesity. It has been hypothesized that dietary cereal grain protein could cause leptin resistance by preventing leptin from binding to its receptor. Non-degraded dietary wheat protein has been found in human serum at a mean level of 41 ng/mL. Here, we report our findings from testing whether enzymatically...

A Population-Based Study of Hepatitis D Virus as Potential Risk Factor for Hepatocellular Carcinoma

Jianguang Ji Jianguang.ji@med 0 Kristina Sundquist 0 Jan Sundquist 0 0 Floor 11, Entrance 72, Skne University Hospital , Malm 205 02, Sweden ( Hepatitis D virus (HDV) is dependent on the presence of