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Place of death in children and young people with cancer and implications for end of life care: a population-based study in England, 1993–2014

Higginson(co-PI), Janet Peacock, Anne Greenough, Julia Verne and Myer Glickman, thank the following members of the Project Advisory Group(PAG): Tony Bonser, Dr Emma Gordon, Fiona Grove, Dr Shaheen Khan, Dr ... Peacock 1 Charles Stiller 6 Claudia Wells 5 Anne Greenough 4 Irene J. Higginson 0 3 0 King's College London, Cicely Saunders Institute, Department of Palliative Care, Policy and Rehabilitation , Bessemer

Randomized controlled trials: who fails run-in?

Background Early identification of participants at risk of run-in failure (RIF) may present opportunities to improve trial efficiency and generalizability. Methods We conducted a partial factorial-design, randomized, controlled trial of calcium and vitamin D to prevent colorectal adenoma recurrence at 11 centers in the United States. At baseline, participants completed two self...

StereoTactic radiotherapy for wet Age-Related macular degeneration (STAR): study protocol for a randomised controlled clinical trial

1 4 Yanzhong Wang 2 Joanna Kelly 8 Caroline Murphy 8 Barnaby C. Reeves 7 Usha Chakravarthy 6 Sarah Wordsworth 5 Cornelius Lewis 10 Janet Peacock 2 Shahir Uddin 1 4 Joe M. O'Sullivan 9 Timothy L

Diagnostic accuracy of 18F amyloid PET tracers for the diagnosis of Alzheimer’s disease: a systematic review and meta-analysis

Imaging or tissue biomarker evidence has been introduced into the core diagnostic pathway for Alzheimer’s disease (AD). PET using 18F-labelled beta-amyloid PET tracers has shown promise for the early diagnosis of AD. However, most studies included only small numbers of participants and no consensus has been reached as to which radiotracer has the highest diagnostic accuracy...

Virtual Touch™ Quantification to Diagnose and Monitor Liver Fibrosis in Hepatitis B and Hepatitis C: A NICE Medical Technology Guidance

Virtual Touch™ Quantification (VTq) is a software application used with Siemens Acuson ultrasound scanners to assess the stiffness of liver tissue. The National Institute for Health and Care Excellence (NICE) Medical Technologies Advisory Committee (MTAC) selected VTq for evaluation and invited the company to submit clinical and economic evidence. King’s Technology Evaluation...

Paclitaxel-coated balloon fistuloplasty versus plain balloon fistuloplasty only to preserve the patency of arteriovenous fistulae used for haemodialysis (PAVE): study protocol for a randomised controlled trial

Background The initial therapy for a stenosis in an arteriovenous fistula used for haemodialysis is radiological balloon dilatation or angioplasty. The benefit of angioplasty is often short-lived, intervention-free survival is reported to be 40–50 % at 1 year. Previous small studies and observational data suggest that paclitaxel-coated balloons may be of benefit in improving...

E-Vita Open Plus for Treating Complex Aneurysms and Dissections of the Thoracic Aorta: A NICE Medical Technology Guidance

The E-vita open plus is a one-stage endoluminal stent graft system used for treating complex aneurysms and dissections of the thoracic aorta. The National Institute for Health and Care Excellence (NICE), as a part of its Medical Technologies Evaluation Programme (MTEP), selected this device for evaluation and invited the manufacturer, JOTEC GmbH, to submit clinical and economic...

RIPOSTE: a framework for improving the design and analysis of laboratory-based research

MESSENGER, AMY E ANDERSON, CHRIS BOOT, CATEY BUNCE, ROBERT D GOLDIN, JESSICA HARRIS, ROD F HINCHLIFFE, HIBA JUNAID, SHAUN KINGSTON, CARMEN MARTIN-RUIZ, CHRISTOPHER P NELSON, JANET PEACOCK, PAUL T SEED ... National Institute for Health Research (NIHR). Michael Messenger (Leeds at M Dawn Teare, Janet Peacock the Leeds Teaching Hospitals NHS Trust) and Bethany Shinkins (Nuffield Department of Primary Care

A prospective study of the impact of serial troponin measurements on the diagnosis of myocardial infarction and hospital and six-month mortality in patients admitted to ICU with non-cardiac diagnoses

Introduction Troponin T (cTnT) elevation is common in patients in the Intensive Care Unit (ICU) and associated with morbidity and mortality. Our aim was to determine the epidemiology of raised cTnT levels and contemporaneous electrocardiogram (ECG) changes suggesting myocardial infarction (MI) in ICU patients admitted for non-cardiac reasons. Methods cTnT and ECGs were recorded...

Survival analysis of 1148 women diagnosed with breast cancer in Southern Iran

Background While there has been much research regarding risk factors and prognostic factors for breast cancer in general, research specific to Iran is sparse. Further, the association between breast cancer survival and socio-demographic and pathologic factors has been widely studied but the majority of these studies are from developed countries. Southern Iran has a population of...

The association of self‐reported violence at home and health in primary school pupils in West London

, Enfield PCT, Holbrook House, Cockfosters Road, Enfield EN4 0DR 3 Janet Peacock, Reader in Medical Statistics 4 Ruth Ruggles, Honorary Clinical Lecturer Background The effects of violence upon young people