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Heparanase Overexpresses in Keratoconic Cornea and Tears Depending on the Pathologic Grade

Javier González,4 Carlos Lisa,1 Jose F. Alfonso,1 Fernando Vazquez,1,2,5 and Luis M. Quirós1,2 1Instituto Universitario Fernández Vega, Universidad de Oviedo & Fundación de Investigación Oftalmológica

Spectral Response of Metallic Optical Antennas Driven by Temperature

When optical antennas are used as light detectors, temperature changes their spectral response. Using this relation, we determine the spectrum of a light beam from an optical antenna’s signal. A numerical evaluation of the temperature-spectral response has been completed with a model for the noise of the device. Using both the response and the noise model, we have established the...

Evolutionary Algorithm Geometry Optimization of Optical Antennas

Printed circuit antennas have been used for the detection of electromagnetic radiation at a wide range of frequencies that go from radio frequencies (RF) up to optical frequencies. The design of printed antennas at optical frequencies has been done by using design rules derived from the radio frequency domain which do not take into account the dispersion of material parameters at...

Spectral Response of Metallic Optical Antennas Driven by Temperature

When optical antennas are used as light detectors, temperature changes their spectral response. Using this relation, we determine the spectrum of a light beam from an optical antenna’s signal. A numerical evaluation of the temperature-spectral response has been completed with a model for the noise of the device. Using both the response and the noise model, we have established the...

Do Low Molecular Weight Agents Cause More Severe Asthma than High Molecular Weight Agents?

Introduction The aim of this study was to analyse whether patients with occupational asthma (OA) caused by low molecular weight (LMW) agents differed from patients with OA caused by high molecular weight (HMW) with regard to risk factors, asthma presentation and severity, and response to various diagnostic tests. Methods Seventy-eight patients with OA diagnosed by positive...

Fibrinolysis and Proliferative Endarteritis: Two Related Processes in Chronic Infections? The Model of the Blood-Borne Pathogen Dirofilaria immitis

The interaction between blood-borne pathogens and fibrinolysis is one of the most important mechanisms that mediate invasion and the establishment of infectious agents in their hosts. However, overproduction of plasmin (final product of the route) has been related in other contexts to proliferation and migration of the arterial wall cells and degradation of the extracellular...

GPCR oligomers in pharmacology and signaling

G protein-coupled receptors (GPCRs) represent one of the largest families of cell surface receptors, and are the target of more than half of the current therapeutic drugs on the market. When activated by an agonist, the GPCR undergoes conformational changes that facilitate its interaction with heterotrimeric G proteins, which then relay signals to downstream intracellular...

Can the activation of plasminogen/plasmin system of the host by metabolic products of Dirofilaria immitis participate in heartworm disease endarteritis?

Background Proliferative endarteritis is one of the key pathological mechanisms of cardiopulmonary dirofilariosis, a cosmopolitan parasitosis caused by Dirofilaria immitis affecting dogs and cats around the world. It has been shown that the excretory/secretory antigens from D. immitis adult worms (DiES) bind plasminogen (PLG) and activate fibrinolysis, which can lead to a...

rAvis: An R-Package for Downloading Information Stored in Proyecto AVIS, a Citizen Science Bird Project

Citizen science projects store an enormous amount of information about species distribution, diversity and characteristics. Researchers are now beginning to make use of this rich collection of data. However, access to these databases is not always straightforward. Apart from the largest and international projects, citizen science repositories often lack specific Application...

Melatonin Activates Endoplasmic Reticulum Stress and Apoptosis in Rats with Diethylnitrosamine-Induced Hepatocarcinogenesis

Hepatocellular carcinoma (HCC) is one of the most lethal human cancers worldwide because of its high incidence, its metastatic potential and the low efficacy of conventional treatment. Inactivation of apoptosis is implicated in tumour progression and chemotherapy resistance, and has been linked to the presence of endoplasmic reticulum stress. Melatonin, the main product of the...

Thermal hydraulic simulations of the Angra 2 PWR

) [Google Scholar] J.J. Duderstadt, L.J. Hamilton, Nuclear Reactor Analysis (John Wiley & Sons Inc., 1976) [Google Scholar] Cite this article as: Javier González-Mantecón, Antonella Lombardi

Motivational interviewing interactions and the primary health care challenges presented by smokers with low motivation to stop smoking: a conversation analysis

Background Research indicates that one third of smokers have low motivation to stop smoking. The purpose of the study was to use Conversational Analysis to enhance understanding of the process in Motivational Interviewing sessions carried out by primary care doctors and nurses to motivate their patients to quit smoking. The present study is a substudy of the Systematic...

A reduced complexity scheme for carrier frequency synchronization in uplink 802.16e OFDMA

Synchronization of the carrier frequency offset (CFO) in the uplink of OFDMA systems is a complex task because each user presents a different CFO. It is performed in two stages: estimation and compensation. Although a few existing schemes already achieve good performance in terms of bit error rate (BER), all of them perform huge amounts of operations, specially during estimation...

Autophagic response in the Rabbit Hemorrhagic Disease, an animal model of virally-induced fulminant hepatic failure

The Rabbit Hemorrhagic Disease Virus (RHDV) induces a severe disease that fulfils many requirements of an animal model of fulminant hepatic failure. However, a better knowledge of molecular mechanisms contributing to liver damage is required, and it is unknown whether the RHDV induces liver autophagy and how it relates to apoptosis. In this study, we attempted to explore which...

An Amphotericin B Derivative Equally Potent to Amphotericin B and with Increased Safety

Amphotericin B is the most potent antimycotic known to date. However due to its large collateral toxicity, its use, although long standing, had been limited. Many attempts have been made to produce derivatives with reduced collateral damage. The molecular mechanism of polyene has also been closely studied for this purpose and understanding it would contribute to the development...

Las TIC y el desarrollo de la capacidad emprendedora. El Boletín de Emprendedor@s

En los últimos años en Europa existe un interés creciente sobre el fomento del espíritu empresarial en el ámbito del sistema educativo. Así en octubre del 2000, el Foro sobre formación en el espíritu empresarial de Niza/Sofía Antípolis, coorganizado por la Comisión Europea y las autoridades francesas, abordó este tema. En otros documentos, como el Libro Verde sobre el espíritu...