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Ready for a world without antibiotics? The Pensières Antibiotic Resistance Call to Action

affiliations. Competing interests Jean Carlet has served as a consultant for Biomerieux, Astra-Zeneca, Astellas, Thermo-Fisher, Da Voltera, and Aromatechnologies. John Conly has received honoraria from the

Antimicrobial resistance: a global view from the 2013 World Healthcare-Associated Infections Forum

Angela Huttner 0 Stephan Harbarth 0 Jean Carlet Sara Cosgrove Herman Goossens Alison Holmes Vincent Jarlier Andreas Voss Didier Pittet 0 for the World Healthcare-Associated Infections Forum ... discussion. Benedetta Allegranzi (WHO), Antoine Andremont (France), Rifat Atun (UK), Lidao Bao (China), Hanan Balkhy (Saudi Arabia), Luis Bavestrello (Chile), Marc Bonten (The Netherlands), Jean Carlet

The World Alliance Against Antibiotic Resistance: Consensus for a Declaration

Antibiotic resistance is increasing worldwide and has become a very important threat to public health. The overconsumption of antibiotics is the most important cause of this problem. We created a World Alliance Against Antibiotic Resistance (WAAAR), which now includes 720 people from 55 different countries and is supported by 145 medical societies or various groups. In June 2014...

De-escalation as a potential way of reducing antibiotic use and antimicrobial resistance in ICU

Jean-Francois Timsit Stephan Harbarth Jean Carlet - First, on an individual basis, antibiotic therapy clearly The study is important because it is the first eagerly awaited increases the risk of

The gut is the epicentre of antibiotic resistance

The gut contains very large numbers of bacteria. Changes in the composition of the gut flora, due in particular to antibiotics, can happen silently, leading to the selection of highly resistant bacteria and Candida species. These resistant organisms may remain for months in the gut of the carrier without causing any symptoms or translocate through the gut epithelium, induce...

Access to antibiotics: a safety and equity challenge for the next decade

Bacterial resistance to antibiotics is increasing worldwide in healthcare settings and in the community. Some microbial pathogens have become resistant to multiple antibiotics, if not all presently available, thus severely compromising treatment success and contributing to enhanced morbidity, mortality, and resource use. The major driver of resistance is misuse of antibiotics in...

WAAR (World Alliance against Antibiotic Resistance): Safeguarding antibiotics

Jean Carlet 0 Claude Rambaud Cline Pulcini on behalf of WAAR international section of the Alliance Contre le dveloppement des Bactries Multi-rsistantes (AC-de-BMR) 0 WAAR , 9 rue de la Terrasse ... achieve this objective. JOIN US NOW, by contacting Jean Carlet, president of WAAR, 9 rue de la terrasse 94000 Crteil, FRANCE jeancarlet@gmail.cofm. Your help is vital!! Acknowledgement We are grateful to

The “Zero Risk” Concept for Hospital-Acquired Infections: A Risky Business!

Jean Carlet () Jacques Fabry Rene Amalberti Laurent Degos Haute Autorite de Sante Saint-Denis La Plaine Universite Claude Bernard Lyon France Nosocomial infections represent a serious public health

Predicting whether the ICU can help older patients: score needed

Because the need for intensive care exceeds its availability in several countries, intensivists must admit those patients most likely to benefit. Intensive care unit admissions of elderly patients will increase substantially in the near future. Decreased self sufficiency and quality of life are common after hospitalization in older patients and they may require discharge to a...

Ten-year decrease of acquired methicillin-resistant Staphylococcus aureus (MRSA) bacteremia at a single institution: the result of a multifaceted program combining cross-transmission prevention and antimicrobial stewardship

Background In France, the proportion of MRSA has been over 25% since 2000. Prevention of hospital-acquired (HA) MRSA spread is based on isolation precautions and antibiotic stewardship. At our institution, before 2000, the Infection Disease and the Infection Control teams had failed to reduce HA-MRSA rates. Objectives and methods We implemented a multifaceted hospital-wide...

Quality of life in patients aged 80 or over after ICU discharge

Introduction Our objective was to describe self-sufficiency and quality of life one year after intensive care unit (ICU) discharge of patients aged 80 years or over. Methods We performed a prospective observational study in a medical-surgical ICU in a tertiary non-university hospital. We included patients aged 80 or over at ICU admission in 2005 or 2006 and we recorded age...

The PIRO Concept: O is for organ dysfunction

Vincent (Brussels , Belgium), Julia Wendon (London, UK), Johan Groeneveld (Amsterdam , The Netherlands), John C Marshall (Toronto , Canada ), Stephen Streat (Auckland , New Zealand) and Jean Carlet (Paris ... would design it a priori for that purpose. [Jean Carlet] I think we need some kind of global score giving an idea of the intensity of the severity of the disease. Its exactly what the people who developed

Moxifloxacin Monotherapy Is Effective in Hospitalized Patients with Community-Acquired Pneumonia: The MOTIV Study—A Randomized Clinical Trial

Carlet 6 Shurjeel Choudhri 5 Amar Kureishi 4 Marie-Aude Le Berre 0 Hartmut Lode 3 John Winter 8 Robert C. Read 7 0 Bayer HealthCare , Puteaux 1 Hospital Mu ́tua de Terrassa, University of Barcelona

Characteristics and determinants of outcome of hospital-acquired bloodstream infections in intensive care units: the EUROBACT International Cohort Study

and Jean-Francois need for developing new antimicrobial agents for MDR Timsit Scientific committee: Piras (PROF, MD, PHD)Cpc, Vitoria Apart Hospital, Jean Carlet, Christian Brun-Buisson, Georges Dimo

Excess Risk of Death from Intensive Care Unit—Acquired Nosocomial Bloodstream Infections: A Reappraisal

(Microbiology Department, Ho pital Necker, Paris, France); Christophe Adrie, MD (ICU, H opital Delafontaine, Saint Denis, France); and Jean Carlet, MD (ICU, Ho pital Saint Joseph, Paris, France); Francois