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167 papers found.
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Skin microcirculatory reactivity assessed using a thermal challenge is decreased in patients with circulatory shock and associated with outcome

BackgroundShock states are characterized by impaired tissue perfusion and microcirculatory alterations, which are directly related to outcome. Skin perfusion can be noninvasively evaluated using skin laser Doppler (SLD), which, when coupled with a local thermal challenge, may provide a measure of microcirculatory reactivity. We hypothesized that this microvascular reactivity...

Correction to: Polymyxin B-immobilized hemoperfusion and mortality in critically ill adult patients with sepsis/septic shock: a systematic review with meta-analysis and trial sequential analysis

Owing to an oversight by the authors, Figure 2 in this article was not the version intended for publication. The correct Figure 2, reproduced here, features footnote symbols and Figure 2b includes three studies as described in the main text.

Prognostic implications of blood lactate concentrations after cardiac arrest: a retrospective study

Background Elevated lactate concentration has been associated with increased mortality after out-of-hospital cardiac arrest (CA). We investigated the variables associated with high blood lactate concentrations and explored the relationship between blood lactate and neurological outcome in this setting. Methods This was a retrospective analysis of an institutional database that...

Endocan as an early biomarker of severity in patients with acute respiratory distress syndrome

Background Plasma concentrations of endocan, a proteoglycan preferentially expressed in the pulmonary vasculature, may represent a biomarker of lung (dys)function. We sought to determine whether the measurement of plasma endocan levels early in the course of acute respiratory distress syndrome (ARDS) could help predict risk of death or of prolonged ventilation. Methods All...

Comparison of the efficacy and safety of FP-1201-lyo (intravenously administered recombinant human interferon beta-1a) and placebo in the treatment of patients with moderate or severe acute respiratory distress syndrome: study protocol for a randomized controlled trial

Michael Quintel 5 Jean-Louis Vincent 0 10 Mikael Maksimow 9 Markku Jalkanen 9 Ilse Piippo 9 V. Marco Ranieri 3 0 Department of Intensive Care, Erasme Hospital, Université libre de Bruxelles , Route de

Paradigm shifts in critical care medicine: the progress we have made

There have really been no single, major, advances in critical care medicine since the specialty came into existence. There has, however, been a gradual, continuous improvement in the process of care over the years, which has resulted in improved patient outcomes. Here, we will highlight just a few of the paradigm shifts we have seen in processes of critical care, including the...

Do we need ARDS?

Jean-Louis Vincent Carlos Santacruz - respiratory failure. As expected, cancer, pulmonary failure can not only help guide treatment but may also fibrosis and vasculitis represented the majority of