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Search: authors:"Jeffrey Haessler"

8 papers found.
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Transethnic insight into the genetics of glycaemic traits: fine-mapping results from the Population Architecture using Genomics and Epidemiology (PAGE) consortium

Aims/hypothesis Elevated levels of fasting glucose and fasting insulin in non-diabetic individuals are markers of dysregulation of glucose metabolism and are strong risk factors for type 2 diabetes. Genome-wide association studies have discovered over 50 SNPs associated with these traits. Most of these loci were discovered in European populations and have not been tested in a ...

Strategies for Enriching Variant Coverage in Candidate Disease Loci on a Multiethnic Genotyping Array

Investigating genetic architecture of complex traits in ancestrally diverse populations is imperative to understand the etiology of disease. However, the current paucity of genetic research in people of African and Latin American ancestry, Hispanic and indigenous peoples in the United States is likely to exacerbate existing health disparities for many common diseases. The ...

Whole-exome imputation of sequence variants identified two novel alleles associated with adult body height in African Americans

Adult body height is a quantitative trait for which genome-wide association studies (GWAS) have identified numerous loci, primarily in European populations. These loci, comprising common variants, explain <10% of the phenotypic variance in height. We searched for novel associations between height and common (minor allele frequency, MAF ≥5%) or infrequent (0.5% < MAF < 5%) variants ...

HNF1B and Endometrial Cancer Risk: Results from the PAGE study

We examined the association between HNF1B variants identified in a recent genome-wide association study and endometrial cancer in two large case-control studies nested in prospective cohorts: the Multiethnic Cohort Study (MEC) and the Women's Health Initiative (WHI) as part of the Population Architecture using Genomics and Epidemiology (PAGE) study. A total of 1,357 incident cases ...

Genetic variants associated with fasting glucose and insulin concentrations in an ethnically diverse population: results from the Population Architecture using Genomics and Epidemiology (PAGE) study

Epidemiology (PAGE) study Megan D Fesinmeyer James B Meigs Kari E North Fredrick R Schumacher Petra Bkov Nora Franceschini Jeffrey Haessler Robert Goodloe Kylee L Spencer Venkata Saroja Voruganti Barbara V

Imputation of coding variants in African Americans: better performance using data from the exome sequencing project

. Lange 13 18 Goo Jun 17 Chris Bizon 16 Shuo Jiao 10 Steven Buyske 15 20 Nora Franceschini 19 Chris S. Carlson 10 Li Hsu 10 Alex P. Reiner 10 Ulrike Peters 10 14 Jeffrey Haessler 10 Keith Curtis 10

Effects of smoking on the genetic risk of obesity: the population architecture using genomics and epidemiology study

Megan D Fesinmeyer 0 Kari E North Unhee Lim Petra Bkov Dana C Crawford Jeffrey Haessler 0 Myron D Gross Jay H Fowke Robert Goodloe Shelley-Ann Love Misa Graff Christopher S Carlson 0 Lewis H Kuller

Evaluation of the Metabochip Genotyping Array in African Americans and Implications for Fine Mapping of GWAS-Identified Loci: The PAGE Study

The Metabochip is a custom genotyping array designed for replication and fine mapping of metabolic, cardiovascular, and anthropometric trait loci and includes low frequency variation content identified from the 1000 Genomes Project. It has 196,725 SNPs concentrated in 257 genomic regions. We evaluated the Metabochip in 5,863 African Americans; 89% of all SNPs passed rigorous ...