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Association of MDM2 expression with shorter progression-free survival and overall survival in patients with advanced pancreatic cancer treated with gemcitabine-based chemotherapy

diluted to 1:100 (#33±7100, Invitrogen Corporation) and anti-p53 diluted to 1:50 (M 7001, Dako). Stained tissue sections were reviewed and scored by a pathologist 2 / 14 (Jen-Chieh Lee) who is an expert in

Clostridium difficile Infections in Medical Intensive Care Units of a Medical Center in Southern Taiwan: Variable Seasonality and Disease Severity

Critical patients are susceptible to Clostridium difficile infections (CDIs), which cause significant morbidity and mortality in the hospital. In Taiwan, the epidemiology of CDI in intensive care units (ICUs) is not well understood. This study was aimed to describe the incidence and the characteristics of CDI in the ICUs of a medical center in southern Taiwan. Adult patients with...

Predominance of Clostridium difficile Ribotypes 017 and 078 among Toxigenic Clinical Isolates in Southern Taiwan

Ribotypes and toxin genotypes of clinical C. difficile isolates in Taiwan are rarely reported. A prospective surveillance study from January 2011 to January 2013 was conducted at the medical wards of a district hospital in southern Taiwan. Of the first toxigenic isolates from 120 patients, 68 (56.7%) of 120 isolates possessed both tcdA and tcdB. Of 52 (43.3%) with tcdB and...

Risk Factors of Fecal Toxigenic or Non-Toxigenic Clostridium difficile Colonization: Impact of Toll-Like Receptor Polymorphisms and Prior Antibiotic Exposure

Hung Hsiao-Ju Lin Tai-Chieh Wu Hsiu-Chuan Liu Jen-Chieh Lee Chih-I Lee Yi- Hui Wu Lei Wan Pei-Jane Tsai Wen-Chien Ko Markus M. Heimesaat, Charite, Campus Benjamin Franklin, Germany Background: This