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7 papers found.
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A cyclin-dependent kinase inhibitor, dinaciclib in preclinical treatment models of thyroid cancer

Background We explored the therapeutic effects of dinaciclib, a cyclin-dependent kinase (CDK) inhibitor, in the treatment of thyroid cancer. Materials and methods Seven cell lines originating from three pathologic types of thyroid cancer (papillary, follicular and anaplastic) were studied. The cytotoxicity of dinaciclib was measured using a lactate dehydrogenase assay. The ...

Long-term follow-up of papillary and follicular thyroid carcinomas with bone metastasis

Availability Statement: All relevant data are within the paper and its Supporting Information file. Funding: This work was supported by grants to Jen-Der Lin from the Chang Gung University (CMRPG3E1901) and the

Soft tissue invasion of papillary thyroid carcinoma

. Persistent or recurrent locoregional PTC did not have better prognosis when compared to distant metastasis. Acknowledgments This work was supported by grants to Jen-Der Lin from Chang Gung University

Utility of a Histone Deacetylase Inhibitor (PXD101) for Thyroid Cancer Treatment

BackgroundWe evaluated the therapeutic effects of the histone deacetylase inhibitor PXD101 alone and in combination with conventional chemotherapy in treating thyroid cancer. Methodology/Principal FindingsWe studied eight cell lines from four types of thyroid cancer (papillary, follicular, anaplastic and medullary). The cytotoxicity of PXD101 alone and in combination with three ...

Disease-Specific Mortality and Secondary Primary Cancer in Well-Differentiated Thyroid Cancer with Type 2 Diabetes Mellitus

Background Increased body mass index is related to the incidence of thyroid cancer. However, the presentation and therapeutic outcomes of different thyroid cancers and type 2 diabetes mellitus (DM) have not been studied. This study investigated the effect of type 2 DM on the clinical presentations and therapeutic outcome of well-differentiated thyroid cancer. Methods and Findings A ...

Utility of a PI3K/mTOR Inhibitor (NVP-BEZ235) for Thyroid Cancer Therapy

Background We assessed the utility of the dual PI3K/mTOR inhibitor NVP-BEZ235 (BEZ235) as single agent therapy and in combination with conventional chemotherapy for thyroid cancer. Methodology/Principal Findings Eight cell lines from four types of thyroid cancer (papillary, follicular, anaplastic, medullary) were studied. The cytotoxicity of BEZ235 and five conventional ...

A population study on the association between leisure time physical activity and self-rated health among diabetics in Taiwan

Background There is strong evidence for the beneficial effects of physical activity in diabetes. There has been little research demonstrating a dose-response relationship between physical activity and self-rated health in diabetics. The aim of this study was to explore the dose-response association between leisure time physical activity and self-rated health among diabetics in ...