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Fatigue Assessment Model of Corroded RC Beams Strengthened with Prestressed CFRP Sheets

This paper presents a fatigue assessment model that was developed for corroded reinforced concrete (RC) beams strengthened using prestressed carbon fiber-reinforced polymer (CFRP) sheets. The proposed model considers the fatigue properties of the constituent materials as well as the section equilibrium. The model provides a rational approach that can be used to explicitly assess ...

Long-term persistent infection of HPV 16 E6 up-regulate SP1 and hTERT by inhibiting LKB1 in lung cancer cells

-Ping Wu. Guang-Ping Wu. Funding acquisition: Guang-Ping Wu. Hua Wang, Guang-Ping Wu. Data curation: Jing-Hua Yang, Xiao-Yan Li, Xin Wang, Wei-Jian Hou, Guang-Ping Wu. Formal analysis: Jing-Hua Yang ... , Xiao-Yan Li, Xin Wang, Wei-Jian Hou, En-Hua Wang, Investigation: Jing-Hua Yang, Xiao-Yan Li, Xin Wang, Wei-Jian Hou, Xue-Shan Qiu, EnMethodology: Jing-Hua Yang, Xiao-Yan Li, Xin Wang, Wei-Jian Hou, Guang

Imatinib attenuates cardiac fibrosis by inhibiting platelet-derived growth factor receptors activation in isoproterenol induced model

Cardiac fibrosis is a significant global health problem with limited treatment choices. Although previous studies have shown that imatinib (IMA) inhibited cardiac fibrosis, the anti-fibrotic mechanisms have not been clearly uncovered. The aim of this study is to evaluate whether IMA attenuates cardiac fibrosis by inhibiting platelet-derived growth factor receptors (PDGFR) on ...

Progressive Collapse Resistance of RC Frames under a Side Column Removal Scenario: The Mechanism Explained

Progressive collapse resistance of RC buildings can be analyzed by considering column loss scenarios. Using finite element analysis and a static test, the progressive collapse process of a RC frame under monotonic vertical displacement of a side column was investigated, simulating a column removal scenario. A single-story 1/3 scale RC frame that comprises two spans and two bays was ...

High IKZF1/3 protein expression is a favorable prognostic factor for survival of relapsed/refractory multiple myeloma patients treated with lenalidomide

The aim of this study is to assess nucleoprotein expression of IKZF1/3 in patients with relapsed/refractory multiple myeloma (MM) who received lenalidomide-based therapy and correlated them with their clinical outcomes. A total of 50 patients diagnosed with MM were entered in the study with the median follow-up of 86.4 months. By immunohistochemistry (IHC), IKZF1 and IKZF3 were ...

A priori error analysis of stabilized mixed finite element method for reaction-diffusion optimal control problems

In this paper, we propose a novel stabilized mixed finite element method for the approximation of optimal control problems governed by reaction-diffusion equations. Compared with the classical mixed finite element methods, the main contributions of this paper are as follows. First, the novel method uses only one stabilization parameter which is not mesh-dependent, and, the new ...

Optimized polymer enhanced foam flooding for ordinary heavy oil reservoir after cross-linked polymer flooding

A successful cross-linked polymer flooding has been implemented in JD reservoir, an ordinary heavy oil reservoir with high permeability zones. For all that, there are still significant volumes of continuous oil remaining in place, which can not be easily extracted due to stronger vertical heterogeneity. Considering selective plugging feature, polymer enhanced foam (PEF) flooding ...

Numerical simulation of reservoir parameters’ synergetic time-variability on development rules

Time variability of reservoir parameters in water flooding has an effect on oilfield development rules. Meanwhile, time variability of different reservoir macro-parameters has certain synergetic relationship with each other. Based on microscopic network simulation and reservoir numerical simulation, a new simulation method is presented, which can describe the influence of reservoir ...

A new method for evaluating the injection effect of chemical flooding

Hall plot analysis, as a widespread injection evaluation method, however, often fails to achieve the desired result because of the inconspicuous change of the curve shape. Based on the cumulative injection volume, injection rate, and the injection pressure, this paper establishes a new method using the ratio of the pressure to the injection rate (RPI) and the rate of change of the ...

Zinc Prevents Abdominal Aortic Aneurysm Formation by Induction of A20-Mediated Suppression of NF-κB Pathway

Chronic inflammation and degradation of elastin are the main processes in the development of abdominal aortic aneurysm (AAA). Recent studies show that zinc has an anti-inflammatory effect. Based on these, zinc may render effective therapy for the treatment of the AAA. Currently, we want to investigate the effects of zinc on AAA progression and its related molecular mechanism. Rat ...

Effect of desmopressin administration on intraoperative blood loss and quality of the surgical field during functional endoscopic sinus surgery: a randomized, clinical trial

Background Bleeding during functional endoscopic sinus surgery is a challenge for the quality of the surgical field for surgeons. This study aimed to evaluate the effect of desmopressin premedication on blood loss and the quality of the surgical field in endoscopic sinus surgery. Methods A total of 90 American Society of Anesthesiologists physical status I–II patients underwent ...

A smoothing method for a class of generalized Nash equilibrium problems

The generalized Nash equilibrium problem is an extension of the standard Nash equilibrium problem where both the utility function and the strategy space of each player depend on the strategies chosen by all other players. Recently, the generalized Nash equilibrium problem has emerged as an effective and powerful tool for modeling a wide class of problems arising in many fields and ...

Safety Evaluation of Neo Transgenic Pigs by Studying Changes in Gut Microbiota Using High-Throughput Sequencing Technology

The neo (neomycin phosphotransferase) gene is widely used as a selection marker in the production of genetically engineered animals and plants. Recent attention has been focused on safety concerns regarding neo transgene expression. In this study, neo transgenic and non-transgenic piglets were randomly assigned into Group A and Group B to evaluate effects of neo transgene by ...

A review of closed-loop reservoir management

The closed-loop reservoir management technique enables a dynamic and real-time optimal production schedule under the existing reservoir conditions to be achieved by adjusting the injection and production strategies. This is one of the most effective ways to exploit limited oil reserves more economically and efficiently. There are two steps in closed-loop reservoir management: ...

Long-term use of lenalidomide and low-dose dexamethasone in Chinese patients with relapsed/refractory multiple myeloma: MM-024 Extended Access Program

Background The efficacy and safety of lenalidomide plus low-dose dexamethasone (Rd) in Chinese patients with relapsed/refractory multiple myeloma (RRMM) was demonstrated in a phase 2, multicenter trial (MM-021). MM-024 was an Extended Access Program (EAP) that allowed responding patients in the MM-021 trial to continue to receive Rd, and to provide additional safety and efficacy ...

Homologous haplotypes, expression, genetic effects and geographic distribution of the wheat yield gene TaGW2

Background TaGW2-6A, cloned in earlier research, strongly influences wheat grain width and TKW. Here, we mainly analyzed haplotypes of TaGW2-6B and their effects on TKW and interaction with haplotypes at TaGW2-6A. Results About 2.9 kb of the promoter sequences of TaGW2-6B and TaGW2-6D were cloned in 34 bread wheat cultivars. Eleven SNPs were detected in the promoter region of ...

A variational inequality method for computing a normalized equilibrium in the generalized Nash game

The generalized Nash equilibrium problem is a generalization of the standard Nash equilibrium problem, in which both the utility function and the strategy space of each player may depend on the strategies chosen by all other players. This problem has been used to model various problems in applications but convergent solution algorithms are extremely scare in the literature. In this ...

Association of Adiposity Indices with Platelet Distribution Width and Mean Platelet Volume in Chinese Adults

Hypoxia is a prominent characteristic of inflammatory tissue lesions. It can affect platelet function. While mean platelet volume (MPV) and platelet distribution width (PDW) are sample platelet indices, they may reflect subcinical platelet activation. To investigated associations between adiposity indices and platelet indices, 17327 eligible individuals (7677 males and 9650 ...

Improved Response Rates with Bortezomib in Relapsed or Refractory Multiple Myeloma: An Observational Study in Chinese Patients

Introduction Bortezomib, a novel proteasome inhibitor, is approved for the treatment of relapsed multiple myeloma (MM). Efficacy and safety of bortezomib is well known; however, it was necessary to validate the data in patients with different ethnic backgrounds. The efficacy and safety of bortezomib was assessed in patients from China with relapsed/refractory MM in a real-world ...