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Establishment of cancer/testis antigen profiling based on clinicopathological characteristics in resected pathological stage III non-small cell lung cancer

Grigorev,3,* Jianhua Li,4 Qingwei Meng,1 Chunyan Wang,1,2 Meiyan Feng,5 Jing Hu,1 Feng Jiang,3 Yan Yu1 1Department of Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, People’s Republic of ... aleksei grigorev 3,* Jianhua li 4 Jing hu 1 *These authors contributed equally to this work Background: Cancer/testis antigen (CTA) expression was found to be highly heterogeneous in previous studies. We

A robust ECC based mutual authentication protocol with anonymity for session initiation protocol

: Gongliang Chen, Jianhua Li. Investigation: Zahid Mehmood. Methodology: Zahid Mehmood. Resources: Gongliang Chen, Jianhua Li, Linsen Li, Bander Alzahrani. Software: Jianhua Li. Supervision: Gongliang Chen

Elimination of persistent vaccine bacteria of Salmonella enterica serovar Typhimurium in the guts of immunized mice by inducible expression of truncated YncE

Orally administered vaccine bacteria usually persist for a period of time in the intestinal tracts of immunized individuals, and are excreted in feces to the environment resulting in a potential biosafety issue. The releasing risk can be minimized by immediate elimination of the persistent vaccine bacteria once adequate protective immune responses have been elicited by the...

Locating Structural Centers: A Density-Based Clustering Method for Community Detection

Uncovering underlying community structures in complex networks has received considerable attention because of its importance in understanding structural attributes and group characteristics of networks. The algorithmic identification of such structures is a significant challenge. Local expanding methods have proven to be efficient and effective in community detection, but most...

Cryptosporidium parvum rhomboid1 has an activity in microneme protein CpGP900 cleavage

Background Apicomplexan parasites actively release transmembrane (TM) adhesive proteins involved in host cell attachment and invasion. Rhomboids, a family of intramembrane serine proteases, cleave these secreted adhesive proteins within their TM domains as an essential step in completing the invasion process. In Cryptosporidium parvum, the activity of rhomboids in cleaving...

A Comprehensive Evaluation of Disease Phenotype Networks for Gene Prioritization

Identification of disease-causing genes is a fundamental challenge for human health studies. The phenotypic similarity among diseases may reflect the interactions at the molecular level, and phenotype comparison can be used to predict disease candidate genes. Online Mendelian Inheritance in Man (OMIM) is a database of human genetic diseases and related genes that has become an...

Phylogenetic Evaluation of Series Delimitations in Section Palmata (Acer, Aceroideae, Sapindaceae) Based on Sequences of Nuclear and Chloroplast Genes


High-Density Lipoprotein (HDL) Counter-Regulates Serum Amyloid A (SAA)-Induced sPLA2-IIE and sPLA2-V Expression in Macrophages

Human serum amyloid A (SAA) has been demonstrated as a chemoattractant and proinflammatory mediator of lethal systemic inflammatory diseases. In the circulation, it can be sequestered by a high-density lipoprotein, HDL, which carries cholesterol, triglycerides, phospholipids and apolipoproteins (Apo-AI). The capture of SAA by HDL results in the displacement of Apo-AI, and the...

Solving nonlinear programming problems with unbounded non-convex constraint sets via a globally convergent algorithm

In this paper, we propose a set of unbounded conditions, under which we are able to solve nonlinear programming problems in a class of unbounded non-convex sets via the combined homotopy interior point algorithm. We also obtain the global convergence of the combined homotopy interior point algorithm and analyze the implementation of this algorithm in detail.

Fluorescent graphene quantum dots as traceable, pH-sensitive drug delivery systems

Fluorescent graphene quantum dots as traceable, pH-sensitive drug delivery systems Jichuan Qiu,1 Ruibin Zhang,2 Jianhua Li,1 Yuanhua Sang,1 Wei Tang,3 Pilar Rivera Gil,4 Hong Liu1,51Center of Bio and

Risk Behaviors, Prevalence of HIV and Hepatitis C Virus Infection and Population Size of Current Injection Drug Users in a China-Myanmar Border City: Results from a Respondent-Driven Sampling Survey in 2012

Background Injection drug use has been the major cause of HIV/AIDS in China in the past two decades. We measured the prevalences of HIV and hepatitis C virus (HCV) prevalence and their associated risk factors among current injection drug users (IDUs) in Ruili city, a border region connecting China with Myanmar that has been undergoing serious drug use and HIV spread problems. An...

Methylation of histone H3 lysine 9 occurs during translation

Histone post-translational modifications are key contributors to chromatin structure and function, and participate in the maintenance of genome stability. Understanding the establishment and maintenance of these marks, along with their misregulation in pathologies is thus a major focus in the field. While we have learned a great deal about the enzymes regulating histone...

Graphene oxide-reinforced biodegradable genipin-cross-linked chitosan fluorescent biocomposite film and its cytocompatibility

Graphene oxide-reinforced biodegradable genipin-cross-linked chitosan fluorescent biocomposite film and its cytocompatibility Jianhua Li,1 Na Ren1, Jichuan Qiu,1 Xiaoning Mou,2 Hong Liu1,21Center of

Optimal chroma-like channel design for passive color image splicing detection

Image splicing is one of the most common image forgeries in our daily life and due to the powerful image manipulation tools, image splicing is becoming easier and easier. Several methods have been proposed for image splicing detection and all of them worked on certain existing color channels. However, the splicing artifacts vary in different color channels and the selection of...

Acupuncture for acute stroke: study protocol for a multicenter, randomized, controlled trial

Background Acupuncture has been widely used as a treatment for stroke in China for more than 3,000 years. However, previous research has not yet shown that acupuncture is effective as a stroke treatment. We report a protocol for a multicenter, randomized, controlled, and outcome assessor-blind trial to evaluate the efficacy and safety of acupuncture on acute ischemic stroke...

Methadone maintenance treatment in China: perceived challenges from the perspectives of service providers and patients

Researcher Haifeng Jiang, Psychiatrist in Residency Ruimin Zhang, Deputy Director Min Zhao, Deputy Director Jianhua Li, Director Yih-Ing Hser , Professor 4 UCLA Integrated Substance Abuse Programs , 11075

Gamma-irradiation increased meiotic crossovers in mouse spermatocytes

In mice, the occurrence of immunofluorescent foci for mismatch repair protein MLH1 correlates closely with the occurrence of crossovers, as detected genetically, and MLH1 foci represent virtually all prospective crossover positions. To examine the effects of γ-irradiation on meiotic crossovers in mouse spermatocytes, male mice were subjected to whole-body γ-irradiation at...

Hydrogen sulfide attenuates spatial memory impairment and hippocampal neuroinflammation in beta-amyloid rat model of Alzheimer’s disease

BackgroundEndogenously produced hydrogen sulfide (H2S) may have multiple functions in brain. An increasing number of studies have demonstrated its anti-inflammatory effects. In the present study, we investigated the effect of sodium hydrosulfide (NaHS, a H2S donor) on cognitive impairment and neuroinflammatory changes induced by injections of Amyloid-β1-40 (Aβ1-40), and explored...

Diagnostic significance of CK19, TG, Ki67 and galectin-3 expression for papillary thyroid carcinoma in the northeastern region of China

Changsi Li 5 Changqing Fang 4 Xiangmin He 3 Jianhua Li 4 0 Department of general surgery, The First affiliated hospital, China Medical University (Nanjing North Street) , Shenyang (110001) , China 1

Sequestering HMGB1 via DNA-Conjugated Beads Ameliorates Murine Colitis

Inflammatory bowel disease (IBD) is chronic inflammation of the gastrointestinal tract that affects millions of people worldwide. Although the etiology of IBD is not clear, it is known that products from stressed cells and enteric microbes promote intestinal inflammation. High mobility group box 1 (HMGB1), originally identified as a nuclear DNA binding protein, is a cytokine-like...