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Identification of Differentially Expressed Long Non-coding RNAs in Polarized Macrophages

University, Nanchang 330006, Jiangxi, ChinaZikun Huang, Qing Luo, Jianqing Ye, Yating Deng & Junming LiDepartment of Clinical Laboratory, Jiangxi Province Blood Center, Nanchang 330006, Jiangxi, ChinaFangyi ... • Google ScholarSearch for Jianqing Ye in:Nature Research journals • PubMed • Google ScholarSearch for Yating Deng in:Nature Research journals • PubMed • Google ScholarSearch for Junming Li in:Nature

Low-Density Granulocytes Are Elevated in Mycobacterial Infection and Associated with the Severity of Tuberculosis

Tuberculosis remains a global health problem caused by infection with Mycobacterium tuberculosis. Numerous studies have established a close correlation between the development of tuberculosis and the roles of neutrophils. Recently, a distinct population of CD15+ granulocytes was found to be present in the peripheral blood mononuclear cell (PBMC) fraction in humans. This...

Mycobacterium tuberculosis-Induced Polarization of Human Macrophage Orchestrates the Formation and Development of Tuberculous Granulomas In Vitro

The tuberculous granuloma is an elaborately organized structure and one of the main histological hallmarks of tuberculosis. Macrophages, which are important immunologic effector and antigen-presenting cells, are the main cell type found in the tuberculous granuloma and have high plasticity. Macrophage polarization during bacterial infection has been elucidated in numerous recent...

PD-L1-expressing neutrophils as a novel indicator to assess disease activity and severity of systemic lupus erythematosus

Background It is well-known that increased frequency of neutrophils was found in patients with systemic lupus erythematosus (SLE). However, the immunomodulatory roles and mechanisms of neutrophils in SLE are poorly understood. Methods Patients with SLE were recruited from the First Affiliated Hospital of Nanchang University. The medical history, clinical manifestations, physical...