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The Dysfunction of the Cerebellum and Its Cerebellum-Reward-Sensorimotor Loops in Chronic Spontaneous Urticaria

Chronic spontaneous urticaria (CSU) is a common itchy skin disease. Despite its prevalence, the neuropathology of CSU is uncertain. In this study, we explored resting state functional connectivity (rs-FC) changes in CSU, as well as how the symptom changes following intervention can modulate rs-FC. Forty patients and 40 healthy controls (HCs) were recruited. Following an...

Tumor location as a novel high risk parameter for stage II colorectal cancers

sex. (DOCX) Acknowledgments The authors wish to acknowledge the staff and patients registered in the SEER database. Author Contributions Conceptualization: BW Jiao Yang MY Jin Yang. Data curation ... : BW Jiao Yang MY. Formal analysis: ZC ML MY. 9 / 13 Software: ZC ML. Writing ± original draft: BW Jiao Yang SL ML ZC. Writing ± review & editing: EL MY Jin Yang. 10 / 13 11 / 13 12 / 13 1. Siegel RL

Invasive lobular carcinoma of the breast: A special histological type compared with invasive ductal carcinoma

Conceptualization: Zheling Chen, Jiao Yang, Shuting Li, Meng Lv, Yanwei Shen, Biyuan Wang, Pan Li, Min Yi, Jin Yang. Formal analysis: Zheling Chen, Jiao Yang, Min Yi, Jin Yang. 14 / 17 Methodology: Zheling Chen ... , Jiao Yang, Min Yi, Jin Yang. Validation: Zheling Chen, Jiao Yang, Meng Lv, Xiao'ai Zhao. Writing ± original draft: Zheling Chen. Writing ± review & editing: Zheling Chen, Lingxiao Zhang, Le Wang, Jin

Surfactant-free Synthesis of CuO with Controllable Morphologies and Enhanced Photocatalytic Property

A green synthesis for nanoleave, nanosheet, spindle-like, rugby-like, dandelion-like and flower-like CuO nanostructures (from 2D to 3D) is successfully achieved through simply hydrothermal synthetic method without the assistance of surfactant. The morphology of CuO nanostructures can be easily tailored by adjusting the amount of ammonia and the source of copper. By designing a...

Overexpression of Hdac6 extends reproductive lifespan in mice

supervised the study, wrote and edited the manuscript. Xiaoxi Zhang, Jiao Yang, Haiying Wang, Renpeng Guo, Yu Yin, Dongdong Zhang, Qian Zhang, Hua Wang, Zhongcheng Zhou, Lingyi Chen, Jun Zhou and Lin Liu ... declare that they have no conflict of interest. All institutional and national guidelines for the care and use of laboratory animals were followed. Xiaoxi Zhang, Jiao Yang, Haiying Wang, Renpeng Guo, Yu

Characteristics of Differently Located Colorectal Cancers Support Proximal and Distal Classification: A Population-Based Study of 57,847 Patients

) Acknowledgments The authors wish to acknowledge the staff and patients registered in the SEER database. 9 / 12 Author Contributions Conceptualization: Jiao Yang MY Jin Yang. Data curation: ML FW. Formal ... analysis: MY. Methodology: Jiao Yang MY Jin Yang. Resources: ZC DD. Supervision: Jin Yang. Writing ± original draft: Jiao Yang. Writing ± review & editing: Jiao Yang XD SL BW YW ZC ML YS XW DD DL FW EL

Synthesis of multi-shelled ZnO hollow microspheres and their improved photocatalytic activity

Herein, we report an effective, facile, and low-cost route for preparing ZnO hollow microspheres with a controlled number of shells composed of small ZnO nanoparticles. The formation mechanism of multiple-shelled structures was investigated in detail. The number of shells is manipulated by using different diameters of carbonaceous microspheres. The products were characterized by...

Comparative Analysis of Clinicopathologic Features of, Treatment in, and Survival of Americans with Lung or Bronchial Cancer

Contributions Conceived and designed the experiments: DL XLD YR PL SL Jiao Yang ML LC XW EL Jin Yang MY. Performed the experiments: DL XLD YR PL SL Jiao Yang ML LC XW EL Jin Yang MY. Analyzed the data: MY ... . Contributed reagents/materials/analysis tools: DL XLD YR PL SL Jiao Yang ML LC XW EL Jin Yang MY. Wrote the paper: DL XLD YR PL SL Jiao Yang ML LC XW EL Jin Yang MY. 13 / 15 14 / 15 1. Holford TR , Levy DT

Utility of gonadotropin-releasing hormone agonists for prevention of chemotherapy-induced ovarian damage in premenopausal women with breast cancer: a systematic review and meta-analysis

,1 Xiao-Man Zhang,1 Meng Lv,1 Ling Chen,1 Tian-Jie Qin,1 Fan Wang,1 Jiao Yang,1 Pei-Jun Liu,2 Jin Yang1 1Department of Medical Oncology, 2Center for Translational Medicine, The First Affiliated

Feasibility and Accuracy of Sentinel Lymph Node Biopsy in Clinically Node-Positive Breast Cancer after Neoadjuvant Chemotherapy: A Meta-Analysis

Sentinel lymph node biopsy (SLNB) has replaced conventional axillary lymph node dissection (ALND) in axillary node-negative breast cancer patients. However, the use of SLNB remains controversial in patients after neoadjuvant chemotherapy (NAC). The aim of this review is to evaluate the feasibility and accuracy of SLNB after NAC in clinically node-positive patients. Systematic...

A Minor (<50%) Signet-Ring Cell Component Associated with Poor Prognosis in Colorectal Cancer Patients: A 26-Year Retrospective Study in China

Background We performed a retrospective study to determine the cancer-specific survival of colorectal cancer patients with a component of signet-ring cells or mucin comprising < 50% of the tumor mass. Methods A total of 2454 patients seen in our hospital from 1985 to 2011 were retrospectively studied. The patients were divided into five groups according to type of cancer: signet...

KSR-Based Medium Improves the Generation of High-Quality Mouse iPS Cells

Induced pluripotent stem (iPS) cells from somatic cells have great potential for regenerative medicine. The efficiency in generation of iPS cells has been significantly improved in recent years. However, the generation of high-quality iPS cells remains of high interest. Consistently, we demonstrate that knockout serum replacement (KSR)-based medium accelerates iPS cell induction...

The Lysine Acetyltransferase Activator Brpf1 Governs Dentate Gyrus Development through Neural Stem Cells and Progenitors

Lysine acetylation has recently emerged as an important post-translational modification in diverse organisms, but relatively little is known about its roles in mammalian development and stem cells. Bromodomain- and PHD finger-containing protein 1 (BRPF1) is a multidomain histone binder and a master activator of three lysine acetyltransferases, MOZ, MORF and HBO1, which are also...

Parathyroid Hormone Administration Improves Bone Marrow Microenvironment and Partially Rescues Haematopoietic Defects in Bmi1-Null Mice

-Jiao Yang 0 Dengshun Miao 0 Zhongjun Zhou, The University of Hong Kong, Hong Kong 0 1 The State Key Laboratory of Reproductive Medicine,The Research Center for Bone and Stem Cells, Department of Human

Speckle tracking echocardiography in the diagnosis of early left ventricular systolic dysfunction in type II diabetic mice

Abstracts Background The leptin receptor-deficient db/db mouse is a well-established type II diabetes animal model used to investigate diabetic cardiomyopathy. Previous reports have documented diabetic cardiomyopathy is accompanied by cardiac structural and functional abnormalities. To better elucidate early or subtle changes in cardiac performance in db/db mice, we used speckle...

The characteristics and expression profiles of the mitochondrial genome for the Mediterranean species of the Bemisia tabaci complex

Background The whiteflies under the name Bemisia tabaci (Gennadius) (Aleyrodidae: Hemiptera) are species complex of at least 31 cryptic species some of which are globally invasive agricultural pests. Previously, the mitochondrial genome (mitogenome) of the indigenous New World B. tabaci species was sequenced and major differences of gene order from the postulated whitefly...

XRCC1 Gene Polymorphisms and the Risk of Differentiated Thyroid Carcinoma (DTC): A Meta-Analysis of Case-Control Studies

Background Previous studies investigating the association between X-ray repair cross-complementing group 1 (XRCC1) polymorphisms and thyroid cancer risk have yielded inconsistent results. This meta-analysis was performed to derive a more precise estimation of the relationship between three XRCC1 polymorphisms and thyroid cancer risk. Methods/Principal Findings PubMed and EMBASE...

The diverse superfamily of lysine acetyltransferases and their roles in leukemia and other diseases

Xiang-Jiao Yang 0 0 Molecular Oncology Group, Department of Medicine, McGill University Health Center , Montre al , Quebec H3A 1A1, Canada Acetylation of the e-amino group of lysine residues, or Ne