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Search: authors:"Jiaying Lin"

4 papers found.
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The prognostic role of the cancer stem cell marker CD44 in ovarian cancer: a meta-analysis

Background CD44 has recently been reported as a cancer stem cell marker in ovarian cancer. However, the clinicopathological and prognostic value of this marker in ovarian cancer remains controversial; Here, we aimed to investigate the correlation between CD44 expression and the clinicopathological features or survival of ovarian cancer patients. Methods An extensive literature ...

Prognostic Significance of Overexpressed p16INK4a in Patients with Cervical Cancer: A Meta-Analysis

Background p16INK4a is a tumor suppressor protein which is induced in cells upon the interaction of high-risk HPV E7 with the retinoblastoma protein by a positive feedback loop, but cannot exert its suppressing effect. Previous reports suggested that p16INK4a immunostaining allows precise identification of even small CIN or cervical cancer lesions in biopsies. The prognostic value ...

New Developments in Therapeutic HPV Vaccines

Human papillomavirus (HPV) infection is the central causal factor in cervical cancer. For years efforts were undertaken to control HPV-associated disease by the development of HPV vaccines. While prophylactic HPV vaccination represents a major public health breakthrough, it is limited to new infection by certain HPV types and does not have therapeutic effects or prevent progression ...

Fusion of EML4 and ALK is associated with development of lung adenocarcinomas lacking EGFR and KRAS mutations and is correlated with ALK expression

Background The anaplastic lymphoma kinase (ALK) gene is frequently involved in translocations that lead to gene fusions in a variety of human malignancies, including lymphoma and lung cancer. Fusion partners of ALK include NPM, EML4, TPM3, ATIC, TFG, CARS, and CLTC. Characterization of ALK fusion patterns and their resulting clinicopathological profiles could be of great benefit in ...