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Patterns of resource utilization and cost for postmenopausal women with hormone-receptor–positive, human epidermal growth factor receptor-2–negative advanced breast cancer in Europe

Background Healthcare resource utilization in breast cancer varies by disease characteristics and treatment choices. However, lack of clarity in guidelines can result in varied interpretation and heterogeneous treatment management and costs. In Europe, the extent of this variability is unclear. Therefore, evaluation of chemotherapy use and costs versus hormone therapy across Europe ...

Preface

his support. The members of the Scientific Organizing Committee of the workshop were Tim Bastian, Marc DeRosa, Haosheng Lin, Vic Pizzo, Steven Tomczyk, Brian Welsch, and Jie Zhang. Open Access This

What Makes a Bacterial Species Pathogenic?:Comparative Genomic Analysis of the Genus Leptospira

Leptospirosis, caused by spirochetes of the genus Leptospira, is a globally widespread, neglected and emerging zoonotic disease. While whole genome analysis of individual pathogenic, intermediately pathogenic and saprophytic Leptospira species has been reported, comprehensive cross-species genomic comparison of all known species of infectious and non-infectious Leptospira, with the ...

Comparative efficacy of everolimus plus exemestane versus fulvestrant for hormone-receptor-positive advanced breast cancer following progression/recurrence after endocrine therapy: a network meta-analysis

Postmenopausal women with advanced breast cancer recurring/progressing on or after initial (adjuvant or first-line) endocrine therapy may be treated multiple times with one of several endocrine or combinatorial targeted treatment options before initiating chemotherapy. In the absence of direct head-to-head comparisons of these treatment options, an indirect comparison can inform ...

Practical Guidelines for the Comprehensive Analysis of ChIP-seq Data

Mapping the chromosomal locations of transcription factors, nucleosomes, histone modifications, chromatin remodeling enzymes, chaperones, and polymerases is one of the key tasks of modern biology, as evidenced by the Encyclopedia of DNA Elements (ENCODE) Project. To this end, chromatin immunoprecipitation followed by high-throughput sequencing (ChIP-seq) is the standard ...

Potential Candidate Genes for Improving Rice Disease Resistance

Diseases caused by fungal and bacterial pathogens like Magnaporthe oryzae and Xanthomonas oryzae pv. oryzae are responsible for considerable yield loss. Up to now, in rice, the modification of the expression of more than 60 genes from diverse origins has shown beneficial effects with respect to disease resistance. In this paper, we review this large set of data to identify the best ...

Implementation and Validation of a New Combined Model for Outdoor to Indoor Radio Coverage Predictions

A new model used to compute the outdoor to indoor signal strength emitted from an outdoor base station is presented. This model is based on the combination of 2 existing models: IRLA (Intelligent Ray Launching), a 3D Ray Optical model especially optimized for outdoor predictions, and MR-FDPF (Multiresolution Frequency Domain ParFlow), a 2D Finite Difference model initially ...

Structural and functional annotation of the porcine immunome

Harry D Dawson Jane E Loveland Graldine Pascal James GR Gilbert Hirohide Uenishi Katherine M Mann Yongming Sang Jie Zhang Denise Carvalho-Silva Toby Hunt Matthew Hardy Zhiliang Hu 0 Shu-Hong Zhao

A mass vaccination campaign targeting adults and children to prevent typhoid fever in Hechi; Expanding the use of Vi polysaccharide vaccine in Southeast China: A cluster-randomized trial

Background One of the goals of this study was to learn the coverage, safety and logistics of a mass vaccination campaign against typhoid fever in children and adults using locally produced typhoid Vi polysaccharide (PS) and group A meningococcal PS vaccines in southern China. Methods The vaccination campaign targeted 118,588 persons in Hechi, Guangxi Province, aged between 5 to 60 ...