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Is gout a risk equivalent to diabetes for stroke and myocardial infarction? A retrospective claims database study

Gout is a risk factor for cardiovascular disease, but associations with specific cardiovascular outcomes, myocardial infarction (MI), and stroke are unclear. Our objective in the present study was to assess whether gout is as strong a risk factor as diabetes mellitus (DM) for incident MI and incident stroke. In this retrospective study, we used U.S. claims data from 2007 to 2010...

China’s engagement with development assistance for health in Africa

Background As an emerging donor in health related development across the world, particularly towards Africa, the People’s Republic of China (PRC) has been increasing its influence within the field of global public health over the past few decades. Yet between the period of 2000 and 2013, little is known about the scope, scale and priority of China’s grant-making programs. Methods...

The pH stability of foot-and-mouth disease virus

to thank Zaixin Liu, Jie Zhang, and Pinghua Li for helpful discussions, continued advice and inspiration. We are also grateful to the state key laboratory veterinary etiological biology where we study

The pH stability of foot-and-mouth disease virus

to thank Zaixin Liu, Jie Zhang, and Pinghua Li for helpful discussions, continued advice and inspiration. We are also grateful to the state key laboratory veterinary etiological biology where we study

The pH stability of foot-and-mouth disease virus

to thank Zaixin Liu, Jie Zhang, and Pinghua Li for helpful discussions, continued advice and inspiration. We are also grateful to the state key laboratory veterinary etiological biology where we study

The pH stability of foot-and-mouth disease virus

to thank Zaixin Liu, Jie Zhang, and Pinghua Li for helpful discussions, continued advice and inspiration. We are also grateful to the state key laboratory veterinary etiological biology where we study

The pH stability of foot-and-mouth disease virus

to thank Zaixin Liu, Jie Zhang, and Pinghua Li for helpful discussions, continued advice and inspiration. We are also grateful to the state key laboratory veterinary etiological biology where we study

SDF-1/CXCR7 axis regulates the proliferation, invasion, adhesion, and angiogenesis of gastric cancer cells

Background More recent studies have revealed that chemokine receptor CXCR7 plays an important role in cancer development. However, little is known about the effect of CXCR7 on the process of gastric cancer cell invasion and angiogenesis. The aim of this study is to investigate the expression of CXCR7 in gastric cancer cell lines and to evaluate the role of CXCR7 in the...

Integrative analysis of somatic mutations and transcriptomic data to functionally stratify breast cancer patients

Background Somatic mutations can be used as potential biomarkers for subtyping and predicting outcomes for cancer patients. However, cancer patients often carry many somatic mutations, which do not always concentrate on specific genomic loci, suggesting that the mutations may affect common pathways or gene interaction networks instead of common genes. The challenge is thus to...

Herpes simplex virus 1 UL41 protein abrogates the antiviral activity of hZAP by degrading its mRNA

Background The zinc finger antiviral protein (ZAP) is a host restriction factor that inhibits the replication of various viruses by degradation of certain viral mRNA. However, previous study demonstrated that ectopic expression of rat ZAP did not suppress the replication of herpes simplex virus type 1 (HSV-1), an archetypal member of the alphaherpesvirus subfamily, and the...

Does ventilator-associated event surveillance detect ventilator-associated pneumonia in intensive care units? A systematic review and meta-analysis

Yanyan Wu Jie Zhang Ming Zhu Lijuan Xiong 0 Equal contributors Department of Nosocomial Infection Management, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , 1277

Effects, safety, and plasma levels of topiroxostat and its metabolites in patients receiving hemodialysis

Background Serum uric acid concentrations have been associated with mortality in patients receiving hemodialysis. Treatment options are sometimes limited because of the accumulation of a drug and/or its metabolites. The aim of the present study is to investigate the efficacy, safety, and plasma levels of topiroxostat, a selective xanthine oxidase inhibitor, and its metabolites in...

The risk of hospitalized infection following initiation of biologic agents versus methotrexate in the treatment of juvenile idiopathic arthritis

Background In the present study, we compared the incidence of hospitalized infection among children with juvenile idiopathic arthritis (JIA) following initiation of treatment with biologic agents versus methotrexate (MTX). Methods We used national Medicaid claims data from 2000 through 2010 to create cohorts of children with JIA who were new users of tumor necrosis factor...

Analysis of health care claims during the peri-transfer stage of transition from pediatric to adult care among juvenile idiopathic arthritis patients

Background To investigate the utilization of health care services before and after transfer from pediatric to adult rheumatology care in clinical practice. Methods Using US commercial claims data from January 2005 through August 2012, we identified individuals with a JIA diagnosis code from a pediatric rheumatologist followed by any diagnosis code from an adult rheumatologist...

Analysis of gene expression in the midgut of Bombyx mori during the larval molting stage

Background Insects can be models for understanding human intestinal infection and pathology. Molting, a special period during which the old insect cuticle is shed and a new one is produced, is crucial for insect development. Holometabolous insects may experience several larva-to-larva moltings to become larger, a pupal molt and adult eclosion to become adults. During the larval...

Quality of life in Chinese family caregivers for elderly people with chronic diseases

Background Inadequate studies have been conducted in China to examine quality of life in family caregivers. Quality of life in family caregivers for elderly people with chronic diseases was evaluated, and the demographic and characteristic factors of both elderly people and their caregivers were explored. Methods The 36-Item Short Form Health Survey (SF-36) was used to assess...

Changes in event-related potentials in patients with first-episode schizophrenia and their siblings

Background This study aimed to explore the characteristics of event-related potentials induced by facial emotion recognition in patients with first-episode schizophrenia and in their siblings. Methods In this case-control study, 30 first-episode schizophrenia patients, 26 siblings, and 30 healthy controls were enrolled. They completed facial emotion recognition tasks from the...

Epidermal growth factor receptor gene mutation status in pure squamous-cell lung cancer in Chinese patients

Background Although new individual treatments continue to reshape the landscape of clinical care in patients with lung cancer, most of the progress has been mainly of benefit to patients with lung adenocarcinomas rather than squamous cell lung carcinoma (SQCLC). Our study aimed to determine whether the epidermal growth factor receptor (EGFR) gene mutation is present in pure SQCLC...

Association between alpha-fetoprotein and metabolic syndrome in a Chinese asymptomatic population: a cross-sectional study

Background Metabolic syndrome is closely associated with an increased risk for fatty liver disease morbidity and mortality. Recently, studies have reported that participants with fatty liver disease have higher serum alpha-fetoprotein levels than those without. We investigated the association between alpha-fetoprotein levels and the prevalence of metabolic syndrome in a Chinese...

High platelet reactivity affects the clinical outcomes of patients undergoing percutaneous coronary intervention

Background The association of platelet reactivity and clinical outcomes, especially stent thrombosis, was not so clear. We sought to investigate whether high platelet reactivity affects clinical outcomes of patients with drug eluting stents (DESs) implantation. Methods All enrolled individuals treated with DESs implantation were evaluated by PL-11, using sequentially platelet...