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Popular Music in Jia Zhangke’s Unknown Pleasures

RESEARCH OF NOTE Jie Zhang Trinity University 1 With his documentary-style films reflecting upon China's unprecedented transformation from a state-controlled to a market-driven economy 1 Jia Zhangke

Aggregation-prone c9FTD/ALS poly(GA) RAN-translated proteins cause neurotoxicity by inducing ER stress

The occurrence of repeat-associated non-ATG (RAN) translation, an atypical form of translation of expanded repeats that results in the synthesis of homopolymeric expansion proteins, is becoming more widely appreciated among microsatellite expansion disorders. Such disorders include amyotrophic lateral sclerosis and frontotemporal dementia caused by a hexanucleotide repeat expansion ...

Antisense transcripts of the expanded C9ORF72 hexanucleotide repeat form nuclear RNA foci and undergo repeat-associated non-ATG translation in c9FTD/ALS

Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) are devastating neurodegenerative disorders with clinical, genetic, and neuropathological overlap. A hexanucleotide (GGGGCC) repeat expansion in a non-coding region of C9ORF72 is the major genetic cause of both diseases. The mechanisms by which this repeat expansion causes “c9FTD/ALS” are not definitively known, ...

Some results on zeros and the uniqueness of one certain type of high difference polynomials

Jie Zhang In this paper, we investigate the distribution of the zeros of some high differential-difference polynomials and obtain some uniqueness theorems with regard to it. MSC: 30D35; 34M10 1

Some results on zeros and the uniqueness of one certain type of high difference polynomials

Jie Zhang In this paper, we investigate the distribution of the zeros of some high differential-difference polynomials and obtain some uniqueness theorems with regard to it. MSC: 30D35; 34M10 1

Clinical analysis and prognostic significance of lymphoma-associated hemophagocytosis in peripheral T cell lymphoma

Wanzhuo Xie Keyue Hu Fan Xu De Zhou Jingsong He Jimin Shi Yi Luo Jingjing Zhu Jie Zhang Maofang Lin Xiujin Ye He Huang Zhen Cai 0 ) Department of Hematology, Bone Marrow Transplant Center, The First

Generation of THz transients by photoexcited single-crystal GaAs meso-structures

We report a sub-picosecond photoresponse and THz transient generation of GaAs single-crystal mesoscopic platelets excited by femtosecond optical pulses. Our structures were fabricated by a top-down technique, by patterning an epitaxial, 500-nm-thick GaAs film grown on top of an AlAs sacrificial layer and then transferring the resulting etched away 10 × 20-μm2 platelets onto an MgO ...

Expression and function of NET-1 in human skin squamous cell carcinoma

To evaluate the clinicopathological significance of NET-1 in human skin squamous cell carcinoma (SSCC). The expression of NET-1 and Ki67 protein was detected using immunostaining from 60 SSCC cases, 50 SIN samples and ten normal skin tissues. The vectors expressing NET-1, siRNA NET-1 and shRNA NET-1 were constructed, as well as negative controls (target-off). In transfected A431 ...

Co-detection in the pathogenesis of severe hand-foot-mouth disease

the specimens and sent them to the lab; Ying-Jie Zhang designed the manuscript. Fang Tang and Jing Wang gave advice when revising the manuscript. Acknowledgments This study was supported by National

The risk of hospitalized infection following initiation of biologic agents versus methotrexate in the treatment of juvenile idiopathic arthritis

Background In the present study, we compared the incidence of hospitalized infection among children with juvenile idiopathic arthritis (JIA) following initiation of treatment with biologic agents versus methotrexate (MTX). Methods We used national Medicaid claims data from 2000 through 2010 to create cohorts of children with JIA who were new users of tumor necrosis factor ...

Cyr61 is involved in neutrophil infiltration in joints by inducing IL-8 production by fibroblast-like synoviocytes in rheumatoid arthritis

Introduction It is well known that neutrophils play very important roles in the development of rheumatoid arthritis (RA) and interleukin (IL)-8 is a critical chemokine in promoting neutrophil migration. We previously showed that increased production of Cyr61 by fibroblast-like synoviocytes (FLS) in RA promotes FLS proliferation and Th17 cell differentiation, thus Cyr61 is a ...

The use, safety, and effectiveness of herpes zoster vaccination in individuals with inflammatory and autoimmune diseases: a longitudinal observational study

Jie Zhang 0 Elizabeth Delzell 0 Fenglong Xie John W Baddley Claire Spettell Raechele M Mcmahan Joaquim Fernandes Lang Chen Kevin Winthrop Jeffrey R Curtis 0 0 Department of Epidemiology, School of

Facility location with double-peaked preferences

sufficiently close for the school to be easily accessible by the Aris Filos-Ratsikas and Jie Zhang were supported by the ERC Advanced Grant 321171 (ALGAME) and the Sino-Danish Center for the Theory of

Mining hidden knowledge for drug safety assessment: topic modeling of LiverTox as a case study

Background Given the significant impact on public health and drug development, drug safety has been a focal point and research emphasis across multiple disciplines in addition to scientific investigation, including consumer advocates, drug developers and regulators. Such a concern and effort has led numerous databases with drug safety information available in the public domain and ...

Multi-dimensional discovery of biomarker and phenotype complexes

Background Given the rapid growth of translational research and personalized healthcare paradigms, the ability to relate and reason upon networks of bio-molecular and phenotypic variables at various levels of granularity in order to diagnose, stage and plan treatments for disease states is highly desirable. Numerous techniques exist that can be used to develop networks of ...

Using gene co-expression network analysis to predict biomarkers for chronic lymphocytic leukemia

Background Chronic lymphocytic leukemia (CLL) is the most common adult leukemia. It is a highly heterogeneous disease, and can be divided roughly into indolent and progressive stages based on classic clinical markers. Immunoglobin heavy chain variable region (IgVH) mutational status was found to be associated with patient survival outcome, and biomarkers linked to the IgVH status ...

Recognition of protein/gene names from text using an ensemble of classifiers

This paper proposes an ensemble of classifiers for biomedical name recognition in which three classifiers, one Support Vector Machine and two discriminative Hidden Markov Models, are combined effectively using a simple majority voting strategy. In addition, we incorporate three post-processing modules, including an abbreviation resolution module, a protein/gene name refinement ...

Expression, purification and biological characterization of the extracellular domain of CD40 from Pichia pastoris

Background CD40, also called Bp50, is a novel member of the TNF receptor superfamily. Based on its important role in multiple physiological and pathological processes, the CD40 signaling pathway has become a vital target for treating transplantation, autoimmune diseases and cancers. This study generated a protein fragment that disrupts this signaling pathway. Results A DNA fragment ...

The efficacy of iodine-125 permanent brachytherapy versus intensity-modulated radiation for inoperable salivary gland malignancies: study protocol of a randomised controlled trial

Background Radiation therapy is the method of choice for subjects with inoperable salivary gland malignancies. I-125 brachytherapy, delivering a high radiation dose to a tumor but sparing surrounding normal tissues, is supposed to be ideal modality for the treatment of salivary gland malignancies. We designed a randomised controlled clinical trial to compare the efficacy of I-125 ...

Prognostic impact of IKZF1 deletion in adults with common B-cell acute lymphoblastic leukemia

Background Interrogate the impact of IKZF1 deletion on therapy-outcomes of adults with common B-cell acute lymphoblastic leukemia. Methods One hundred sixty-five consecutive adults with common B-cell ALL were tested for IKZF1 deletion and for BCR/ABL. Deletions in IKZF1 were detected using multiplex RQ-PCR, multiplex fluorescent PCR, sequence analysis and multiplex ...