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407 papers found.
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128-Slice Acceletated-Pitch Dual Energy CT Angiography of the Head and Neck: Comparison of Different Low Contrast Medium Volumes

BackgroundOur study aims to evaluate the image quality and feasibility of 128-slice dual-energy CTA (DE-CTA) for supra-aortic arteries using reduced amounts of contrast medium (CM). MethodsA prospective study was performed in 54 patients receiving CTA of the head and neck with a 128-slice dual-source CT system. Patients were randomized into two groups with a volume of either 40 mL ...

20-HETE Mediates Ozone-Induced, Neutrophil-Independent Airway Hyper-Responsiveness in Mice

Background Ozone, a pollutant known to induce airway hyper-responsiveness (AHR), increases morbidity and mortality in patients with obstructive airway diseases and asthma. We postulate oxidized lipids mediate in vivo ozone-induced AHR in murine airways. Methodology/Principal Findings Male BALB/c mice were exposed to ozone (3 or 6 ppm) or filtered air (controls) for 2 h. Precision ...

7H-benzo[c]fluorene: a major DNA adduct-forming component of coal tar

Coal tar is a complex mixture that exhibits high carcinogenic potency in lungs of animals when administered in the diet. Studies have noted that lung tumor induction does not correlate with the benzo[a]pyrene content of coal tar, suggesting that other hydrocarbons may be involved in the observed tumorigenicity. Our previous studies have demonstrated that a major `unknown' ...

A Cationic-Independent Mannose 6-Phosphate Receptor Inhibitor (PXS64) Ameliorates Kidney Fibrosis by Inhibiting Activation of Transforming Growth Factor-β1

The activity of transforming growth factor-β1 (TGF-β1) is regulated by its conversion from the latent to the active form. We have previously shown that the conversion is at least in part mediated by the cationic-independent mannose 6-phosphate receptor (CI-M6PR), as the CI-M6PR inhibitor, PXS-25 has anti-fibrotic properties in human kidney tubular (HK-2) cells under high glucose ...

A Malus Crabapple Chalcone Synthase Gene, McCHS, Regulates Red Petal Color and Flavonoid Biosynthesis

Chalcone synthase is a key and often rate-limiting enzyme in the biosynthesis of anthocyanin pigments that accumulate in plant organs such as flowers and fruits, but the relationship between CHS expression and the petal coloration level in different cultivars is still unclear. In this study, three typical crabapple cultivars were chosen based on different petal colors and ...

A Method of Neighbor Classes Based SVM Classification for Optical Printed Chinese Character Recognition

In optical printed Chinese character recognition (OPCCR), many classifiers have been proposed for the recognition. Among the classifiers, support vector machine (SVM) might be the best classifier. However, SVM is a classifier for two classes. When it is used for multi-classes in OPCCR, its computation is time-consuming. Thus, we propose a neighbor classes based SVM (NC-SVM) to ...

A Pig Model of Ischemic Mitral Regurgitation Induced by Mitral Chordae Tendinae Rupture and Implantation of an Ameroid Constrictor

A miniature pig model of ischemic mitral regurgitation (IMR) was developed by posterior mitral chordae tendinae rupture and implantation of an ameroid constrictor. A 2.5-mm ameroid constrictor was placed around the left circumflex coronary artery (LCX) of male Tibetan miniature pigs to induce ischemia, while the posterior mitral chordae tendinae was also ruptured. X-ray coronary ...

A Site-Specific Integrative Plasmid Found in Pseudomonas aeruginosa Clinical Isolate HS87 along with A Plasmid Carrying an Aminoglycoside-Resistant Gene

Plasmids play critical roles in bacterial fitness and evolution of Pseudomonas aeruginosa. Here two plasmids found in a drug-resistant P. aeruginosa clinical isolate HS87 were completely sequenced. The pHS87b plasmid (11.2 kb) carries phage-related genes and function-unknown genes. Notably, pHS87b encodes an integrase and has an adjacent tRNAThr-associated attachment site. A ...

A Sugar Gustatory Receptor Identified from the Foregut of Cotton Bollworm Helicoverpa armigera

Wei Xu Hui-Jie Zhang Alisha Anderson 0 ) CSIRO Ecosystem Sciences , Black Mountain, Australian Capital Territory 2601, Australia Helicoverpa armigera (Hbner) is one of the most polyphagous and

A Survey of the Perceived Risk for Stroke among Community Residents in Western Urban China

Background and Purpose Persons who perceive their risk for stroke can promote the intervention of stroke risk factors and reduce the risk of stroke occurrence. Our purpose was to assess the knowledge of stroke risk factors and the level of perceived risk for stroke. Methods In 2011, a population-based face-to-face interview survey was conducted in Yuzhong district, Chongqing. A ...

A Targetron System for Gene Targeting in Thermophiles and Its Application in Clostridium thermocellum

Background Targetrons are gene targeting vectors derived from mobile group II introns. They consist of an autocatalytic intron RNA (a “ribozyme”) and an intron-encoded reverse transcriptase, which use their combined activities to achieve highly efficient site-specific DNA integration with readily programmable DNA target specificity. Methodology/Principal Findings Here, we used a ...

A comparison of the Medieval Warm Period, Little Ice Age and 20th century warming simulated by the FGOALS climate system model

To compare differences among the Medieval Warm Period (MWP), Little Ice Age (LIA), and 20th century global warming (20CW), six sets of transient and equilibrium simulations were generated using the climate system model FGOALS_gl. This model was developed by the State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics, Institute of ...

A context-aware framework for the efficient integration of femtocells in IP and cellular infrastructures

In today’s heterogeneous networking (HetNet) environments, where end users are provided with universal connectivity opportunities, femtocell deployments can become key players in the enhancement of critical performance indicators such as capacity, coverage, QoS, etc. In order to confront the up-to-date LTE femtocell challenges, we propose a context-aware framework that provides a ...

A digital model individual template and CT-guided 125I seed implants for malignant tumors of the head and neck

To enhance the accuracy of radioactive seed implants in the head and neck, a digital model individual template, containing information simultaneously on needle pathway and facial features, was designed to guide implantation with CT imaging. Thirty-one patients with recurrent and local advanced malignant tumors of head and neck after prior surgery and radiotherapy were involved in ...

A high-density genetic map for anchoring genome sequences and identifying QTLs associated with dwarf vine in pumpkin (Cucurbita maxima Duch.)

Background Pumpkin (Cucurbita maxima Duch.) is an economically important crop belonging to the Cucurbitaceae family. However, very few genomic and genetic resources are available for this species. As part of our ongoing efforts to sequence the pumpkin genome, high-density genetic map is essential for anchoring and orienting the assembled scaffolds. In addition, a saturated genetic ...

A highly sensitive detection for foot-and-mouth disease virus by gold nanopariticle improved immuno-PCR

Backgroud Foot-and-mouth disease (FMD) is one of the most contagious of all artiodactyl animal diseases, and its infection has an obvious ability to spread over long distances and to contribute to epidemics in FMD-free areas. A highly sensitive and specific method is required to detect FMDV. In this study, we evaluated the usefulness of a bio-barcode assay (BCA) technique for ...

A mass vaccination campaign targeting adults and children to prevent typhoid fever in Hechi; Expanding the use of Vi polysaccharide vaccine in Southeast China: A cluster-randomized trial

Background One of the goals of this study was to learn the coverage, safety and logistics of a mass vaccination campaign against typhoid fever in children and adults using locally produced typhoid Vi polysaccharide (PS) and group A meningococcal PS vaccines in southern China. Methods The vaccination campaign targeted 118,588 persons in Hechi, Guangxi Province, aged between 5 to 60 ...

A nested case-control study indicating heavy metal residues in meconium associate with maternal gestational diabetes mellitus risk

Background Environmental pollutant exposure may play certain roles in the pathogenesis and progression of diabetes mellitus including gestational diabetes mellitus (GDM). We hypothesize that heavy metal exposure may trigger GDM during pregnancy. The objective of this study was to investigate the possible associations between selected heavy metal exposure and GDM risk. Methods This ...

A note on the optimality condition for a bilevel programming

The equality type Mordukhovich coderivative rule for a solution mapping to a second-order cone constrained parametric variational inequality is derived under the constraint nondegenerate condition, which improves the result published recently. The rule established is then applied to deriving a necessary and sufficient local optimality condition for a bilevel programming with a ...

A novel approach to investigate tissue-specific trinucleotide repeat instability

Background In Huntington's disease (HD), an expanded CAG repeat produces characteristic striatal neurodegeneration. Interestingly, the HD CAG repeat, whose length determines age at onset, undergoes tissue-specific somatic instability, predominant in the striatum, suggesting that tissue-specific CAG length changes could modify the disease process. Therefore, understanding the ...