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Control of occlusion of middle cerebral artery in perinatal and neonatal mice with magnetic force

Ischemic perinatal stroke (IPS) is common, resulting in significant mortality and morbidity. In such cases, the incidence of unilateral arterial cerebral infarction is often occluded in the middle cerebral artery (MCA), leading to focal ischemia. In adult rodents, blockage of MCA is the most frequently used strategy for ischemic stroke study. However, modeling MCA occlusion (MCAo...

The Ontology of Biological and Clinical Statistics (OBCS)-based statistical method standardization and meta-analysis of host responses to yellow fever vaccines

WITH ETHICS GUIDELINES The authors Jie Zheng, Hua Li, Qingzhi Liu, and Yongqun He declare they have no conflict of interests. All the data sets the authors used are from public repositories. 1. Zheng

Lipid binding promotes the open conformation and tumor-suppressive activity of neurofibromin 2

IzardDepartment of Molecular Medicine, The Scripps Research Institute, Jupiter, FL, 33458, USAVinay Mandati, Jie Zheng, Patrick R. Griffin & Joseph KissilGlobal Phasing Ltd., Sheraton House, Castle Park, Cambridge ... journals • PubMed • Google Scholar Search for Jie Zheng in:Nature Research journals • PubMed • Google Scholar Search for Andrew J. Sharff in:Nature Research journals • PubMed • Google Scholar Search for

Understand spiciness: mechanism of TRPV1 channel activation by capsaicin

-like repeat domain; CAP, capsaicin; cryo-EM, Cryoelectron microscopy; MD, molecular dynamics; TRPV1, transient receptor potential vanilloid 1. COMPLIANCE WITH ETHICS GUIDELINES Fan Yang and Jie Zheng

Control Strategy for Small Molecule Impurities in Antibody-Drug Conjugates

Antibody-drug conjugates (ADCs) are an emerging class of biopharmaceuticals. As such, there are no specific guidelines addressing impurity limits and qualification requirements. The current ICH guidelines on impurities, Q3A (Impurities in New Drug Substances), Q3B (Impurities in New Drug Products), and Q6B (Specifications: Test Procedures and Acceptance Criteria for...

Recent Developments in Mendelian Randomization Studies

Jie Zheng, Denis Baird, Maria-Carolina Borges, Jack Bowden, Gibran Hemani, Philip Haycock, David M. Evans and George Davey Smith each declare no potential conflicts of interest. Human and Animal Rights ... intervention targets for disease prevention in the future. Mendelian randomization; Databases and automation tools for causal inference; Hypothesis-free causality; Drug development; Disease progression - Jie

Survey on the levels of 25-hydroxy vitamin D and bone metabolic markers and evaluation of their correlations with osteoporosis in perimenopausal woman in Xi’an region

, Ning Zhang, Xiaoqin Wang. Formal analysis: Ping Zhou, Jian Hu. Investigation: Ping Zhou, Jian Hu, Ping Xi, Bo Yang, Jie Zheng. Methodology: Ping Zhou, Jian Hu, Bo Yang. Project administration ... : Xiaoqin Wang. Resources: Ping Xi, Jie Zheng. Software: Ping Xi, Ning Zhang, Jie Zheng. Validation: Ning Zhang. Writing ± original draft: Ping Zhou, Jian Hu. Writing ± review & editing: Xiaoqin Wang. 12

Power-Law Modeling of Cancer Cell Fates Driven by Signaling Data to Reveal Drug Effects

Extracellular signals are captured and transmitted by signaling proteins inside a cell. An important type of cellular responses to the signals is the cell fate decision, e.g., apoptosis. However, the underlying mechanisms of cell fate regulation are still unclear, thus comprehensive and detailed kinetic models are not yet available. Alternatively, data-driven models are promising...

De Ritis ratio (AST/ALT) as an independent predictor of poor outcome in patients with acute ischemic stroke

De Ritis ratio (AST/ALT) as an independent predictor of poor outcome in patients with acute ischemic stroke Fan Gao,1 Chen Chen,2 Jun Lu,1 Jie Zheng,1 Xian-Cang Ma,1,3 Xing-Yun Yuan,2 Kang Huo,2 Jian

The use status of anticoagulation drugs for inpatients with nonvalvular atrial fibrillation in Southwest China

The use status of anticoagulation drugs for inpatients with nonvalvular atrial fibrillation in Southwest China Huan Jie Zheng, Shu Kun Ouyang, Yue Zhao, Kai Lu, Su Xin Luo, Hua Xiao Department of

Knowledge-guided fuzzy logic modeling to infer cellular signaling networks from proteomic data

• PubMed • Google ScholarSearch for Shuigeng Zhou in:Nature Research journals • PubMed • Google ScholarSearch for Jie Zheng in:Nature Research journals • PubMed • Google Scholar Contributions H.L. and J.Z ... proofreading to improve the ideas and writing of the manuscript. Competing interests The authors declare no competing financial interests. Corresponding author Correspondence to Jie Zheng. Rights and

Facile Fabrication of Multi-hierarchical Porous Polyaniline Composite as Pressure Sensor and Gas Sensor with Adjustable Sensitivity

A multi-hierarchical porous polyaniline (PANI) composite which could be used in good performance pressure sensor and adjustable sensitivity gas sensor has been fabricated by a facile in situ polymerization. Commercial grade sponge was utilized as a template scaffold to deposit PANI via in situ polymerization. With abundant interconnected pores throughout the whole structure, the...

SynLethDB: synthetic lethality database toward discovery of selective and sensitive anticancer drug targets

Synthetic lethality (SL) is a type of genetic interaction between two genes such that simultaneous perturbations of the two genes result in cell death or a dramatic decrease of cell viability, while a perturbation of either gene alone is not lethal. SL reflects the biologically endogenous difference between cancer cells and normal cells, and thus the inhibition of SL partners of...

Content-Based Discovery for Web Map Service using Support Vector Machine and User Relevance Feedback

Many discovery methods for geographic information services have been proposed. There are approaches for finding and matching geographic information services, methods for constructing geographic information service classification schemes, and automatic geographic information discovery. Overall, the efficiency of the geographic information discovery keeps improving., There are...

The Effects of Natural Chinese Medicine Aconite Root, Dried Ginger Rhizome, and Coptis on Rectal and Skin Temperatures at Acupuncture Points

Zheng,1 Yan Sun,1 Yu-Shan Gao,1 Shu-Jing Zhang,1 Peng-Fei Kang,1 Lin Chen,1 Meng-Yao Wu,1 Sheng-Yong Xu,2 and Yu-Hang Li1 1School of Basic Medical Science, Beijing University of Chinese Medicine, No. 11

Detection of QTLs for Yield Heterosis in Rice Using a RIL Population and Its Testcross Population

-Hua Zhang conducted the field experiments. Jie-Zheng Ying and Ye-Yang Fan carried out the marker analysis. All authors read and approved the final manuscript. Acknowledgments This research was funded by

Extortion can outperform generosity in the iterated prisoner’s dilemma

Research Grant (20151080396 and 20151080397) and Chinese University of Hong Kong Direct Grant. Author information Author notesZhijian Wang, Jaimie W. Lien & Jie Zheng These authors contributed equally to ... for Yanran Zhou in:Nature Research journals • PubMed • Google ScholarSearch for Jaimie W. Lien in:Nature Research journals • PubMed • Google ScholarSearch for Jie Zheng in:Nature Research journals

Ontobee: A linked ontology data server to support ontology term dereferencing, linkage, query and integration

Linked Data (LD) aims to achieve interconnected data by representing entities using Unified Resource Identifiers (URIs), and sharing information using Resource Description Frameworks (RDFs) and HTTP. Ontologies, which logically represent entities and relations in specific domains, are the basis of LD. Ontobee (http://www.ontobee.org/) is a linked ontology data server that stores...

Construction and validation of a three-dimensional finite element model of degenerative scoliosis

Background With the aging of the population, degenerative scoliosis (DS) incidence rate is increasing. In recent years, increasing research on this topic has been carried out, yet biomechanical research on the subject is seldom seen and in vitro biomechanical model of DS nearly cannot be available. The objective of this study was to develop and validate a complete three...

Water-enhanced Removal of Ciprofloxacin from Water by Porous Graphene Hydrogel

Research journals • PubMed • Google ScholarSearch for Mingxuan Yang in:Nature Research journals • PubMed • Google ScholarSearch for Fei Yu in:Nature Research journals • PubMed • Google ScholarSearch for Jie ... Zheng in:Nature Research journals • PubMed • Google Scholar Contributions M.J. and Y.M. wrote the main manuscript text, Y.F. and Z.J. help revise this manuscript and improve the language. All authors