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Association of peptic ulcer disease with obesity, nutritional components, and blood parameters in the Korean population

Contributions Conceptualization: Bum Ju Lee. Data curation: Jihye Kim, Keun Ho Kim, Bum Ju Lee. Formal analysis: Jihye Kim, Bum Ju Lee. Funding acquisition: Keun Ho Kim. Investigation: Jihye Kim, Bum Ju Lee ... . Methodology: Bum Ju Lee. Project administration: Keun Ho Kim. Resources: Keun Ho Kim. Validation: Bum Ju Lee. Writing ± original draft: Jihye Kim, Bum Ju Lee. Writing ± review & editing: Bum Ju Lee. 11 / 14

A high throughput serum bactericidal assay for antibodies to Haemophilus influenzae type b

Background The protective capacities of antibodies induced with Haemophilus influenzae type b (Hib) vaccines can be directly assessed in vitro with a Hib-specific serum bactericidal assay (SBA). However, the conventional SBA requires several tedious steps including manual counting of bacterial colonies, and therefore, it is seldom used. Methods To overcome these limitations, we...

Interaction of iron status with single nucleotide polymorphisms on incidence of type 2 diabetes

The objective of this study is to find single nucleotide polymorphisms (SNPs) associated with a risk of Type 2 diabetes (T2D) in Korean adults and to investigate the longitudinal association between these SNPs and T2D and the interaction effects of iron intake and average hemoglobin level. Data from the KoGES_Ansan and Ansung Study were used. Gene-iron interaction analysis was...

No Interaction with Alcohol Consumption, but Independent Effect of C12orf51 (HECTD4) on Type 2 Diabetes Mellitus in Korean Adults Aged 40-69 Years: The KoGES_Ansan and Ansung Study

Previously, genetic polymorphisms of C12orf51 (HECTD4) (rs2074356 and/or rs11066280) have been shown to be related to alcohol consumption and type 2 diabetes (T2D). This study aimed to prospectively examine whether C12orf51 had an interaction with or independent effect on alcohol consumption and the risk of T2D. The present study included 3,244 men and 3,629 women aged 40 to 69...

A Novel Human scFv Library with Non-Combinatorial Synthetic CDR Diversity

The present work describes the construction and validation of a human scFv library with a novel design approach to synthetic complementarity determining region (CDR) diversification. The advantage of synthetic antibody libraries includes the possibility of exerting fine control over factors like framework sequences, amino acid and codon usage, and CDR diversity. However, random...

Characterization of Mammalian ADAM2 and Its Absence from Human Sperm

the experiments: HC SJ JTK Jihye Kim JJ Jaehwan Kim SJ. Analyzed the data: HC ZYP CC. Contributed reagents/materials/ analysis tools: KJJ KP. Wrote the paper: HC CC. 17 / 21 18 / 21 19 / 21 20 / 21 1

Identifying kinase dependency in cancer cells by integrating high-throughput drug screening and kinase inhibition data

Motivation: Targeted kinase inhibitors have dramatically improved cancer treatment, but kinase dependency for an individual patient or cancer cell can be challenging to predict. Kinase dependency does not always correspond with gene expression and mutation status. High-throughput drug screens are powerful tools for determining kinase dependency, but drug polypharmacology can make...

Cannabinoids Regulate Bcl-2 and Cyclin D2 Expression in Pancreatic β Cells

Recent reports have shown that cannabinoid 1 receptors (CB1Rs) are expressed in pancreatic β cells, where they induce cell death and cell cycle arrest by directly inhibiting insulin receptor activation. Here, we report that CB1Rs regulate the expression of the anti-apoptotic protein Bcl-2 and cell cycle regulator cyclin D2 in pancreatic β cells. Treatment of MIN6 and βTC6 cells...

Happier People Show Greater Neural Connectivity during Negative Self-Referential Processing

: EJK Joohan Kim JJK. Performed the experiments: JWC Jihye Kim. Analyzed the data: SK SWC HJP. Contributed reagents/materials/analysis tools: HJP Joohan Kim. Wrote the paper: EJK RJD JJK. 13 / 15 14 / 15

One Urban College of Education's Examination of Graduates’ Employment and Retention in Public Schools

Retention in Public Schools Ruchi Bhatnagar 0 Joyce E. Many 0 0 Georgia State University , USA - Article 4 Ruchi Bhatnagar Georgia State University Jihye Kim Georgia State University Joyce E. Many

Long Term Storage of Dry versus Frozen RNA for Next Generation Molecular Studies

The standard method for the storage and preservation of RNA has been at ultra-low temperatures. However, reliance on liquid nitrogen and freezers for storage of RNA has multiple downsides. Recently new techniques have been developed for storing RNA at room temperature utilizing desiccation and are reported to be an effective alternative for preserving RNA integrity. In this study...

K-Map: connecting kinases with therapeutics for drug repurposing and development

Protein kinases play important roles in regulating signal transduction in eukaryotic cells. Due to evolutionary conserved binding sites in the catalytic domain of the kinases, most inhibitors that target these sites promiscuously inhibit multiple kinases. Quantitative analysis can reveal complex and unexpected interactions between protein kinases and kinase inhibitors, providing...

Nuclear Receptor Expression and Function in Human Lung Cancer Pathogenesis

. Endocr Rev . 2008 ; 29 ( 6 ): 677 - 96 . Epub 2008 /07/31. doi: 10.1210/er.2008-0017 PMID: 18664618. 45. Jihye Kim YJ . Postttanslational Modification of PPARγ upon Pathophysiological Change . Journal of

An integrated bioinformatics analysis to dissect kinase dependency in triple negative breast cancer

Background Triple-Negative Breast Cancer (TNBC) is an aggressive disease with a poor prognosis. Clinically, TNBC patients have limited treatment options besides chemotherapy. The goal of this study was to determine the kinase dependency in TNBC cell lines and to predict compounds that could inhibit these kinases using integrative bioinformatics analysis. Results We integrated...

Identification and Characterization of Germ Cell Genes Expressed in the F9 Testicular Teratoma Stem Cell Line

Jihye Kim JJ. Analyzed the data: JTK CC. Contributed reagents/materials/analysis tools: Jaehwan Kim YK. Contributed to the writing of the manuscript: JTK CC. 1. Eddy EM ( 1995 ) ' Chauvinist genes' of

An Inducible TGF-β2-TGFβR Pathway Modulates the Sensitivity of HNSCC Cells to Tyrosine Kinase Inhibitors Targeting Dominant Receptor Tyrosine Kinases

The epidermal growth factor receptor (EGFR) is overexpressed in approximately 90% of head and neck squamous cell carcinomas (HNSCC), and molecularly targeted therapy against the EGFR with the monoclonal antibody cetuximab modestly increases overall survival in head and neck cancer patients. We hypothesize that co-signaling through additional pathways limits the efficacy of...

Bioinformatics-driven discovery of rational combination for overcoming EGFR-mutant lung cancer resistance to EGFR therapy

Motivation: Non–small-cell lung cancer (NSCLC) is the leading cause of cancer death in the United States. Targeted tyrosine kinase inhibitors (TKIs) directed against the epidermal growth factor receptor (EGFR) have been widely and successfully used in treating NSCLC patients with activating EGFR mutations. Unfortunately, the duration of response is short-lived, and all patients...

ABA Renewal Involves Enhancements in Both GluA2-Lacking AMPA Receptor Activity and GluA1 Phosphorylation in the Lateral Amygdala

SP Jihye Kim BA. Analyzed the data: KP HWL Sukwon Lee HK JCL Seungbok Lee SC. Wrote the paper: Sukwon Lee SC. 1. Hermans D , Craske MG , Mineka S , Lovibond PF ( 2006 ) Extinction in human fear

Genomic Signatures of Pregnancy-Associated Breast Cancer Epithelia and Stroma and their Regulation by Estrogens and Progesterone

Pregnancy-associated breast cancers (PABC) generally present at advanced stages and have a poor prognosis. The reasons are unclear but we hypothesized that the continuous high levels of estrogens and progesterone were involved. We have now carried out a detailed analysis of PABC compared to tumors of age-matched nonpregnant (non-PABC) women. Malignant epithelia and tumor...