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Ancestors’ dietary patterns and environments could drive positive selection in genes involved in micronutrient metabolism—the case of cofactor transporters

. Competing interests Jim Kaput works for the Nestlé Institute of Health Sciences. The other authors declare that they have no competing interests. Publisher’s Note Springer Nature remains neutral with regard

Propelling the paradigm shift from reductionism to systems nutrition

The complex physiology of living organisms represents a challenge for mechanistic understanding of the action of dietary bioactives in the human body and of their possible role in health and disease. Animal, cell, and microbial models have been extensively used to address questions that could not be pursued experimentally in humans, posing an additional level of complexity in...

The genomics of micronutrient requirements

interest, Jim Kaput works for Nestle´ Institute of Health Sciences, and Martin Kussmman works for Nestle´ Institute of Health Sciences. Aasheim ET , Hofsø D , Hjelmesaeth J et al ( 2008 ) Vitamin status in

Human nutrition, environment, and health

Sciences , Lausanne , Switzerland 1 This Editorial is the introduction to the Topical Collection on Systems Health and Nutrition, guest edited by Jim Kaput, Martin Kussmann, and Marijana Radonjic. The Guest

Proposed guidelines to evaluate scientific validity and evidence for genotype-based dietary advice

Fallaize Michael Fenech Lynnette R. Ferguson Eileen R. Gibney 9 Mike Gibney 9 Ingrid M. F. Gjelstad Jim Kaput Anette S. Karlsen Silvia Kolossa 2 Julie Lovegrove Anna L. Macready Cyril F. M. Marsaux J

Enabling nutrient security and sustainability through systems research

Human and companion animal health depends upon nutritional quality of foods. Seed varieties, seasonal and local growing conditions, transportation, food processing, and storage, and local food customs can influence the nutrient content of food. A new and intensive area of investigation is emerging that recognizes many factors in these agri-food systems that influence the...

Metabolic fate of fructose in human adipocytes: a targeted 13C tracer fate association study

The development of obesity is becoming an international problem and the role of fructose is unclear. Studies using liver tissue and hepatocytes have contributed to the understanding of fructose metabolism. Excess fructose consumption also affects extra hepatic tissues including adipose tissue. The effects of fructose on human adipocytes are not yet fully characterized, although...

Genetic associations with micronutrient levels identified in immune and gastrointestinal networks

The discovery of vitamins and clarification of their role in preventing frank essential nutrient deficiencies occurred in the early 1900s. Much vitamin research has understandably focused on public health and the effects of single nutrients to alleviate acute conditions. The physiological processes for maintaining health, however, are complex systems that depend upon interactions...

Gene Expression Variability in Human Hepatic Drug Metabolizing Enzymes and Transporters

Interindividual variability in the expression of drug-metabolizing enzymes and transporters (DMETs) in human liver may contribute to interindividual differences in drug efficacy and adverse reactions. Published studies that analyzed variability in the expression of DMET genes were limited by sample sizes and the number of genes profiled. We systematically analyzed the expression...

Connecting the Human Variome Project to nutrigenomics

Nutrigenomics is the science of analyzing and understanding gene–nutrient interactions, which because of the genetic heterogeneity, varying degrees of interaction among gene products, and the environmental diversity is a complex science. Although much knowledge of human diversity has been accumulated, estimates suggest that ~90% of genetic variation has not yet been characterized...

Two new ArrayTrack libraries for personalized biomedical research

Jim Kaput 2 0 Z-Tech Corporation, an ICF International company at NCTR, National Center for Toxicological Research , 3900 NCTR Rd., Jefferson, AR 72079 , USA 1 Center for Toxicoinformatics, Division of

Assessment of dietary intake: NuGO symposium report

physical activity assessments In the concluding presentation of the symposium, Jim Kaput (National Center for Toxicological Research/FDA, USA) introduced the concept of personalised nutrition based on

A Systems Biology Strategy for Predicting Similarities and Differences of Drug Effects: Evidence for Drug-specific Modulation of Inflammation in Atherosclerosis

Background Successful drug development has been hampered by a limited understanding of how to translate laboratory-based biological discoveries into safe and effective medicines. We have developed a generic method for predicting the effects of drugs on biological processes. Information derived from the chemical structure and experimental omics data from short-term efficacy...

Assessing batch effects of genotype calling algorithm BRLMM for the Affymetrix GeneChip Human Mapping 500 K array set using 270 HapMap samples

Background Genome-wide association studies (GWAS) aim to identify genetic variants (usually single nucleotide polymorphisms [SNPs]) across the entire human genome that are associated with phenotypic traits such as disease status and drug response. Highly accurate and reproducible genotype calling are paramount since errors introduced by calling algorithms can lead to inflation of...

The Micronutrient Genomics Project: a community-driven knowledge base for micronutrient research

Micronutrients influence multiple metabolic pathways including oxidative and inflammatory processes. Optimum micronutrient supply is important for the maintenance of homeostasis in metabolism and, ultimately, for maintaining good health. With advances in systems biology and genomics technologies, it is becoming feasible to assess the activity of single and multiple micronutrients...

Challenges of molecular nutrition research 6: the nutritional phenotype database to store, share and evaluate nutritional systems biology studies

The challenge of modern nutrition and health research is to identify food-based strategies promoting life-long optimal health and well-being. This research is complex because it exploits a multitude of bioactive compounds acting on an extensive network of interacting processes. Whereas nutrition research can profit enormously from the revolution in ‘omics’ technologies, it has...