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Differential Changes of Aorta and Carotid Vasodilation in Type 2 Diabetic GK and OLETF Rats: Paradoxical Roles of Hyperglycemia and Insulin

Nakamura,2 Yi-Chen Chen,1 Cong-Zhen Qiao,1 Jin He,1 Jie Yang,1 Chuan Zhang,3 Zdravko Kamenov,4 Hideaki Higashino,2 and Hong Chen1 1Department of Pharmacology and Shanghai Key Laboratory of Vascular Biology ... . Mei-Fang Zhong, Masaki Tabuchi, Kyoko Nakamura, Yi-Chen Chen, Cong-Zhen Qiao and Jin He performed the functional and biochemical experiments. Wei-Li Shen, Yi-Chen Chen and Jie Yang performed the Western

Alteration of T cell immunity by lentiviral transduction of human monocyte-derived dendritic cells

Xiaochuan Chen 0 Jin He 0 Lung-Ji Chang 0 0 Address: Department of Molecular Genetics and Microbiology, Powell Gene Therapy Center, McKnight Brain Institute, University of Florida College of

REGγ is critical for skin carcinogenesis by modulating the Wnt/β-catenin pathway

200003, ChinaLei Li, Jishen Zhang, Wangjun Yan, Dianwen Song, Tielong Liu, Xinghai Yang, Cheng Yang, Xiaopan Cai, Wei Xu, Quan Huang, Jin He & Jianru XiaoShanghai Key Laboratory of Regulatory Biology ... ScholarSearch for Wei Xu in:Nature Research journals • PubMed • Google ScholarSearch for Quan Huang in:Nature Research journals • PubMed • Google ScholarSearch for Jin He in:Nature Research journals • PubMed

Bone Marrow Stromal Cells Derived MCP-1 Reverses the Inhibitory Effects of Multiple Myeloma Cells on Osteoclastogenesis by Upregulating the RANK Expression

Multiple myeloma (MM) cells are responsible for aberrant osteoclast (OC) activation. However, when cocultured monocytes, but not OC precursors, with MM cells, we made a novel observation that MM cells inhibited receptor activator of nuclear factor κB ligand (RANKL)-induced increase of OC differentiation, OC gene expression, signaling pathways and bone resorption activity. Our...

Protein Profiling of Preeclampsia Placental Tissues

Lian Wei Li Xiufen Liu Hongmei Xu Jing Jiang Peng Lee David Y. Zhang Jin He Fei Ye Emanuele Buratti, International Centre for Genetic Engineering and Biotechnology, Italy Preeclampsia is a multi

Alveolar adenoma combined with multifocal cysts: Case report and literature review

Alveolar adenoma is an extremely rare and benign pulmonary neoplasm; it is always asymptomatic and is usually detected incidentally on routine chest X-radiography. Typically on imaging examinations, alveolar adenoma exhibits as a peripheral, solitary, cystic nodule in the lung, which may easily imitate other lung lesions, consequently leading to difficulties in the differential...

Determination of the Crystal Structure and Active Residues of FabV, the Enoyl-ACP Reductase from Xanthomonas oryzae

Background Enoyl-ACP reductase (ENR) catalyses the last reduction reaction in the fatty acid elongation cycle in bacteria and is a good antimicrobial target candidate. FabV is the most recently discovered class of ENR, but we lack information about the atomic structure and the key residues involved in reductase activity except for the known conserved tyrosine and lysine residues...

Inhibition of the MDM2 E3 Ligase Induces Apoptosis and Autophagy in Wild-Type and Mutant p53 Models of Multiple Myeloma, and Acts Synergistically with ABT-737

Intracellular proteolytic pathways have been validated as rational targets in multiple myeloma with the approval of two proteasome inhibitors in this disease, and with the finding that immunomodulatory agents work through an E3 ubiquitin ligase containing Cereblon. Another E3 ligase that could be a rational target is the murine double minute (MDM) 2 protein, which plays a role in...

CotA, a Multicopper Oxidase from Bacillus pumilus WH4, Exhibits Manganese-Oxidase Activity

Multicopper oxidases (MCOs) are a family of enzymes that use copper ions as cofactors to oxidize various substrates. Previous research has demonstrated that several MCOs such as MnxG, MofA and MoxA can act as putative Mn(II) oxidases. Meanwhile, the endospore coat protein CotA from Bacillus species has been confirmed as a typical MCO. To study the relationship between CotA and...

High-Throughput Identification of Promoters and Screening of Highly Active Promoter-5′-UTR DNA Region with Different Characteristics from Bacillus thuringiensis

In bacteria, both promoters and 5′-untranslated regions (5′-UTRs) of mRNAs play vital regulatory roles in gene expression. In this study, we identified 1203 active promoter candidates in Bacillus thuringiensis through analysis of the genome-wide TSSs based on the transcriptome data. There were 11 types of σ-factor and 34 types of transcription factor binding sites found in 723...

Genomic Analysis of a Mycobacterium Bovis Bacillus Calmette-Guérin Strain Isolated from an Adult Patient with Pulmonary Tuberculosis

For years, bacillus Calmette-Guérin (BCG) has served as the unique vaccine against tuberculosis and has generally been regarded as safe. However, a clinical strain labeled 3281 that was isolated from a TB patient was identified to be BCG. Via the combination of next-generation sequencing (NGS) and comparative genomic analysis, unique 3281 genetic characteristics were revealed. A...

Effect of controlled rolling/controlled cooling parameters on microstructure and mechanical properties of the novel pipeline steel

The study of controlled rolling/controlled cooling process parameters which affect the microstructure and mechanical properties of a novel pipeline steel have been optimized by the orthogonal experiment with four factors and three levels in this paper. However, the parameters of thermo-mechanical control process (TMCP) optimized by the Gleeble-3500 hot simulator could not satisfy...

High-Performance Fluorescence Molecular Tomography through Shape-Based Reconstruction Using Spherical Harmonics Parameterization

Fluorescence molecular tomography in the near-infrared region is becoming a powerful modality for mapping the three-dimensional quantitative distributions of fluorochromes in live small animals. However, wider application of fluorescence molecular tomography still requires more accurate and stable reconstruction tools. We propose a shape-based reconstruction method that uses...

Systematic Evaluation of Genetic Variants for Polycystic Ovary Syndrome in a Chinese Population

To date, eleven genome-wide significant (GWS) loci (P < 5×10−8) for polycystic ovary syndrome (PCOS) have been identified through genome-wide association studies (GWAS). Some of the risk loci have been selected for replications and validated in multiple ethnicities, however, few previous studies investigated all loci. Scanning all the GWAS variants would demonstrate a more...

SVM-Based Synthetic Fingerprint Discrimination Algorithm and Quantitative Optimization Strategy

Synthetic fingerprints are a potential threat to automatic fingerprint identification systems (AFISs). In this paper, we propose an algorithm to discriminate synthetic fingerprints from real ones. First, four typical characteristic factors—the ridge distance features, global gray features, frequency feature and Harris Corner feature—are extracted. Then, a support vector machine...

Nucleotide binding by the widespread high-affinity cyclic di-GMP receptor MshEN domain

• PubMed • Google ScholarSearch for Zhi-Le Tu in:Nature Research journals • PubMed • Google ScholarSearch for Jin He in:Nature Research journals • PubMed • Google ScholarSearch for Christopher J. Jones

Characterization of a natural triple-tandem c-di-GMP riboswitch and application of the riboswitch-based dual-fluorescence reporter

• Google ScholarSearch for Shan-Ho Chou in:Nature Research journals • PubMed • Google ScholarSearch for Jin He in:Nature Research journals • PubMed • Google Scholar Contributions J.H. conceived and designed ... declare no competing financial interests. Corresponding author Correspondence to Jin He. Supplementary information PDF files1.Supplementary Information Rights and permissions This work is

Molecular phylogeny, divergence time estimates and historical biogeography within one of the world's largest monocot genera

manuscript. Xian-Qin Wei conducted 1 years of fieldwork. De-Qing Huang made valuable comments on the manuscript. Xing-Jin He and Song-Dong Zhou made valuable comments on the manuscript and provided technical

A Highly Controllable Electrochemical Anodization Process to Fabricate Porous Anodic Aluminum Oxide Membranes

Jin He Wenli Wang 0 Zhiyong Fan 1 0 College of Textile and Clothing Engineering, Soochow University , Suzhou 215021 , China 1 Department of Electronic and Computer Engineering, The Hong Kong