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Quantification of motor network dynamics in Parkinson’s disease by means of landscape and flux theory

The basal ganglia neural circuit plays an important role in motor control. Despite the significant efforts, the understanding of the principles and underlying mechanisms of this modulatory circuit and the emergence of abnormal synchronized oscillations in movement disorders is still challenging. Dopamine loss has been proved to be responsible for Parkinson’s disease. We ...

CHOP favors endoplasmic reticulum stress-induced apoptosis in hepatocellular carcinoma cells via inhibition of autophagy

. Methodology: Bingshuang Ren, Shihuai Zhan, Yunfeng Fu. Software: Jun Lu. Supervision: Lianghu Huang, Jianming Tan. Writing ± original draft: Jin Wang. Writing ± review & editing: Shuiliang Wang. 15 / 17 16

Uncovering the molecular and physiological processes of anticancer leads binding human serum albumin: A physical insight into drug efficacy

Human serum albumin (HSA) has its ability to bind drug molecules and influence their efficacies. Although anticancer leads NSC48693 and NSC290956 functioned at the same mechanism, the drug efficacies were obviously distinct. To gain insight into the distinct drug efficacy, the molecular and physiological processes of anticancer leads binding HSA have been investigated via a ...

Electrostatic forces govern the binding mechanism of intrinsically disordered histone chaperones

function in vivo without having stabilized structures, researchers are motivated to revisit the long holding idea Ministry of Science and Technology of the PeopleÂs Republic of China, Jin Wang; and The ... National Science Foundation, grant number PHY-76066, URL = https://www.nsf.gov/, National Science Foundation of American, Jin Wang. that protein function is structurally determined [ 2 ]. Accumulating

The Enhanced Photo-Electrochemical Detection of Uric Acid on Au Nanoparticles Modified Glassy Carbon Electrode

In this work, a sensitive and novel method for determining uric acid (UA) has been developed, in which the glassy carbon electrode (GCE) was modified with electrodeposition Au nanoparticles and used to monitor the concentration of UA with the assistant of visible light illumination. The morphology of the Au nanoparticles deposited on GCE surface were characterized by scanning ...

Prognostic significance of neutrophil-to-lymphocyte ratio in diffuse large B-cell lymphoma: A meta-analysis

Background Neutrophil-to-lymphocyte ratio (NLR) has been investigated as a prognostic marker in patients with diffuse large B-cell lymphoma (DLBCL); however, the results remain controversial. This study aimed to explore the association between NLR and survival outcomes and clinicopathological factors in DLBCL. Methods Relevant studies were retrieved by searching PubMed, Embase, Web ...

Unlocking the vital role of host cells in hair follicle reconstruction by semi-permeable capsules

Organ regeneration is becoming a promising choice for many patients; however, many details about the mechanisms underlying organ regeneration remain unknown. As regenerative organs, hair follicles offer a good model to study the mechanisms associated with regenerative medicine. The relevant studies have mainly focused on donor cells, and there are no systematic studies involving ...

A high-speed phosphorescent LED-based visible light communication system utilizing SQGNRC precoding technique

University in 2006 and 2009, respectively. During 2009-, she studies satellite thermal design drawing analysis in China Academy of Space Technology Xi’an. Yan-Jin Wang received the bachelor degree in

A Physical Mechanism and Global Quantification of Breast Cancer

Initiation and progression of cancer depend on many factors. Those on the genetic level are often considered crucial. To gain insight into the physical mechanisms of breast cancer, we construct a gene regulatory network (GRN) which reflects both genetic and environmental aspects of breast cancer. The construction of the GRN is based on available experimental data. Three basins of ...

Selection of key sequence-based features for prediction of essential genes in 31 diverse bacterial species

Genes that are indispensable for survival are essential genes. Many features have been proposed for computational prediction of essential genes. In this paper, the least absolute shrinkage and selection operator method was used to screen key sequence-based features related to gene essentiality. To assess the effects, the selected features were used to predict the essential genes ...

Risk factors for delay of adjuvant chemotherapy in non-metastatic breast cancer patients: A systematic review and meta-analysis involving 186982 patients

Purpose Delay performance of adjuvant chemotherapy (AC) after surgery has been presented to affect survival of breast cancer patients adversely, but the risk factors for delay in initiation remain controversial. Therefore, we conducted this systematic review of the literature and meta-analysis aiming at identifying the risk factors for delay of adjuvant chemotherapy (DAC) in ...

Surface sediment properties and heavy metal pollution assessment in the Pearl River Estuary, China

Grain size and concentrations of heavy metals (arsenic (As), cadmium (Cd), chromium (Cr), copper (Cu), mercury (Hg), lead (Pb), and zinc (Zn)) of 148 surface sediments and activities of 210Pb and heavy metal concetrantions of one sediment core from the Pearl River Estuary were analyzed. The surface sediments were dominated by silt and sandy silt. Sediment type controlled the ...

Vehicle networking data-upload strategy based on mobile cloud services

While traditional vehicle network communication architecture is based on special short-range communication, it is difficult to meet the demand for quality of service of vehicle networking data transmission. The relevant data can be uploaded to the server through the mobile gateway, which can be transmitted to the target vehicle by the decision of the server, which can then extend ...

Characterization of quadratic growth of extended-real-valued functions

This paper shows that the sharpest possible bound in the second-order growth condition of a proper lower semicontinuous function can be attained under some assumptions. We also establish a relationship among strong metric subregularity, quadratic growth, the positive-definiteness property of the second-order subdifferential/generalized Hessian, the strong metric regularity, and ...

Network overhead crowd management mechanism of virtual mobile Internet

It has become the hot research issue that solves the bottleneck of resource management in the development of Internet through virtualization. However, there are the challenges of mobility management, resource management, and network overhead management in the virtualization of the Internet. First, based on the mobile Internet network construction and management mode, the mobile ...

Is aspirin associated with diabetic retinopathy? The Singapore Epidemiology of Eye Disease (SEED) study

Background/Aims To determine the association between aspirin use and diabetic retinopathy (DR) among persons with diabetes, in a population-based, cross-sectional study. Methods Subjects with diabetes aged >40 years from the Singapore Epidemiology of Eye Diseases Study were enrolled in this study. Retinal photographs were graded for DR according to the modified Airlie House ...

Ascorbic acid metabolism during sweet cherry (Prunus avium) fruit development

To elucidate metabolism of ascorbic acid (AsA) in sweet cherry fruit (Prunus avium ‘Hongdeng’), we quantified AsA concentration, cloned sequences involved in AsA metabolism and investigated their mRNA expression levels, and determined the activity levels of selected enzymes during fruit development and maturation. We found that AsA concentration was highest at the petal-fall period ...

Cytoreductive nephrectomy with thrombectomy before targeted therapy improves survival for metastatic renal cell carcinoma with venous tumor thrombus: a single-center experience

Background The aim of the study is to evaluate the role of cytoreductive nephrectomy (CN) with thrombectomy before targeted molecular therapy (TMT) on survival in metastatic renal cell carcinoma (mRCC) with venous tumor thrombus. Methods We performed a retrospective analysis of 47 patients treated in our center from April 2008 to October 2014. In the study, 20 patients underwent CN ...

Language background in early life may be related to neuropsychiatry symptoms in patients with Alzheimer disease

Background The relationship between early life experience and the occurrence of neuropsychiatry symptoms (NPSs) in patients with Alzheimer disease (AD) is unclear. Methods From 2012 to 2014, we prospectively recruited 250 patients with probable AD from the memory clinic of Taipei Veterans General Hospital. All patients underwent standard assessments, including brain magnetic ...

Overexpression of Rad51 Predicts Poor Prognosis in Colorectal Cancer: Our Experience with 54 Patients

Background Aberrant Rad51 expression is implicated in the progression of human malignancies. However, the role of Rad51 in colorectal cancer (CRC) remains undefined. This study aimed to establish a relationship between Rad51 and clinicopathologic features of CRC. Methods We retrospectively examined the paraffin-embedded tissue samples obtained from 54 patients with CRC who had ...