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AKI - experimental models

Introduction and Aims:Clinical studies have demonstrated the risk of chronic kidney disease after the occurrence of an acute kidney injury (AKI). Experimental works indicate that AKI result in incomplete repair, persistent tubulointerstitial inflammation and fibrosis. Cysteine-rich protein 61 (Cyr61), a secreted matrix-associated protein, has been found to be up-regulated in the...

A mass vaccination campaign targeting adults and children to prevent typhoid fever in Hechi; Expanding the use of Vi polysaccharide vaccine in Southeast China: A cluster-randomized trial

Background One of the goals of this study was to learn the coverage, safety and logistics of a mass vaccination campaign against typhoid fever in children and adults using locally produced typhoid Vi polysaccharide (PS) and group A meningococcal PS vaccines in southern China. Methods The vaccination campaign targeted 118,588 persons in Hechi, Guangxi Province, aged between 5 to...

A mass vaccination campaign targeting adults and children to prevent typhoid fever in Hechi; Expanding the use of Vi polysaccharide vaccine in Southeast China: A cluster-randomized trial

, SwitzerlandTikki PangUniversity of Western Ontario, CanadaAllan Donner AuthorsSearch for Jin Yang in:PubMed • Google Scholar Search for Camilo J Acosta in:PubMed • Google Scholar Search for Guo-ai Si in:PubMed

Sequence and structure of Brassica rapa chromosome A3

Yang Hee-Ju Yu Ik-Young Choi Beom-Soon Choi Su Ryun Choi Nirala Ramchiary Yong Pyo Lim Fiona Fraser Nizar Drou Eleni Soumpourou Martin Trick Ian Bancroft Andrew G Sharpe Isobel AP Parkin Jacqueline

Genome-wide comparative analysis of the Brassica rapa gene space reveals genome shrinkage and differential loss of duplicated genes after whole genome triplication

-Jin Kwon*, Tae-Jin Yang, Young-Joo Seol*, Mina Jin Jin-A Kim Myung-Ho Lim Jung Sun Kim Seunghoon Baek Beom-Soon Choi Hee-Ju Yu Dae-Soo Kim Namshin Kim Ki- Byung Lim Soo-In Lee Jang-Ho Hahn Yong Pyo Lim

Heat shock protein 70-mediated sensitization of cells to apoptosis by Carboxyl-Terminal Modulator Protein

Background The serine/threonine protein kinase B (PKB/Akt) is involved in insulin signaling, cellular survival, and transformation. Carboxyl-terminal modulator protein (CTMP) has been identified as a novel PKB binding partner in a yeast two-hybrid screen, and appears to be a negative PKB regulator with tumor suppressor-like properties. In the present study we investigate novel...

Localization of the intrinsically bent DNA region upstream of the E.coli rrnB P1 promoter

DNA sequences upstream of the rrnB P1 core promoter (−10, −35 region) increase transcription more than 300-fold in vivo and in vitro. This stimulation results from a cis-acting DNA sequence, the UP element, which interacts directly with the alpha subunit of RNA polymerase, increasing transcription about 30-fold, and from a positively acting transcription factor, FIS, which...

Short- and long-term outcomes of single bare metal stent versus drug eluting stent in nondiabetic patients with a simple de novo lesion in the middle and large vessel

Objective This study was aimed to investigate the short- and long-term outcomes of percutaneous coronary intervention (PCI) between single bare metal stent (BMS) and single drug eluting stent (DES) in nondiabetic patients with a simple de novo lesion in the middle and large vessel. Methods Two hundred and thirty-five consecutive patients with a simple de novo lesion in the middle...

Short- and long-term outcomes of single bare metal stent versus drug eluting stent in nondiabetic patients with a simple de novo lesion in the middle and large vessel

This study was aimed to investigate the short- and long-term outcomes of percutaneous coronary intervention (PCI) between single bare metal stent (BMS) and single drug eluting stent (DES) in nondiabetic patients with a simple de novo lesion in the middle and large vessel. Two hundred and thirty-five consecutive patients with a simple de novo lesion in the middle and large vessel...

The first generation of a BAC-based physical map of Brassica rapa

Background The genus Brassica includes the most extensively cultivated vegetable crops worldwide. Investigation of the Brassica genome presents excellent challenges to study plant genome evolution and divergence of gene function associated with polyploidy and genome hybridization. A physical map of the B. rapa genome is a fundamental tool for analysis of Brassica "A" genome...

Sustained activation of protein kinase C downregulates nuclear factor-κB signaling by dissociation of IKK-γ and Hsp90 complex in human colonic epithelial cells

Activation of protein kinase C (PKC) by phorbol 12-myristate 13-acetate (PMA) triggers cellular signals that lead to the activation of the transcription factor NF-κB (nuclear factor kappaB) in various cell types. In addition to NF-κB activation by short-time PMA treatment, here we report that the prolonged exposure of human colonic cancer epithelial cells treated with PMA can...

The rubber tree genome reveals new insights into rubber production and species adaptation

, Jin Yang & Shuangli LiBukit Bandar Raya, 59100 Kuala Lumpur, MalaysiaHoong-Yeet YeangCIRAD, UMR AGAP, F-34398, Montpellier, FrancePascal MontoroNutrition and Genomics Laboratory, JM-USDA Human Nutrition ... Cheng in:Nature Research journals • PubMed • Google ScholarSearch for Ying Liu in:Nature Research journals • PubMed • Google ScholarSearch for Jin Yang in:Nature Research journals • PubMed • Google

Complexity of genome evolution by segmental rearrangement in Brassica rapa revealed by sequence-level analysis

Background The Brassica species, related to Arabidopsis thaliana, include an important group of crops and represent an excellent system for studying the evolutionary consequences of polyploidy. Previous studies have led to a proposed structure for an ancestral karyotype and models for the evolution of the B. rapa genome by triplication and segmental rearrangement, but these have...

A Novel Missense Mutation, F826Y, in the Mineralocorticoid Receptor Gene in Japanese Hypertensives: Its Implications for Clinical Phenotypes

A gain-of-function mutation resulting in the S810L amino acid substitution in the hormone-binding domain of the mineralocorticoid receptor (MR, locus symbol NR3C2) is responsible for early-onset hypertension that is exacerbated in pregnancy. The objective of this study was to test whether other types of missense mutations in the hormone-binding domain could be implicated in...

Association of Genetic Polymorphisms of Endothelin-Converting Enzyme-1 Gene with Hypertension in a Japanese Population and Rare Missense Mutation in Preproendothelin-1 in Japanese Hypertensives

Hypertensives Mariko BANNO Hironori HANADA Kei KAMIDE Yoshihiro KOKUBO Akiko KADA Jin YANG Chihiro TANAKA Shin TAKIUCHI Takeshi HORIO Tetsutaro MATAYOSHI Hisayo YASUDA Junko NAGURA Hitonobu TOMOIKE Yuhei KAWANO

New reference genome sequences of hot pepper reveal the massive evolution of plant disease-resistance genes by retroduplication

Transposable elements are major evolutionary forces which can cause new genome structure and species diversification. The role of transposable elements in the expansion of nucleotide-binding and leucine-rich-repeat proteins (NLRs), the major disease-resistance gene families, has been unexplored in plants. We report two high-quality de novo genomes (Capsicum baccatum and C...

Tissue-specific expression and subcellular localization of ALADIN, the absence of which causes human triple A syndrome

Triple A syndrome is a rare genetic disorder caused by mutations in the achalasia-addisonianism-alacrima syndrome (AAAS) gene which encodes a tryptophan aspartic acid (WD) repeat-containing protein named alacrima-achalasia-adrenal insufficiency neurologic disorder (ALADIN). Northern blot analysis shows that the 2.1 kb AAAS mRNA is expressed in various tissues with stronger...

Association of intima-media thickening of carotid artery with genetic polymorphisms of the regulator of G-protein signaling 2 gene in patients with hypertension and in the general population

, Suita, Osaka, JapanYoshihiro Kokubo & Tomonori OkamuraResearch Institute, National Cerebral and Cardiovascular Center, Suita, Osaka, JapanKei Kamide, Jin Yang, Sachiko Matsumoto, Mariko Banno & Toshiyuki ... in:Nature Research journals • PubMed • Google ScholarSearch for Jin Yang in:Nature Research journals • PubMed • Google ScholarSearch for Shin Takiuchi in:Nature Research journals • PubMed • Google

Associations of Hypertension and Its Complications with Variations in the Xanthine Dehydrogenase Gene

Hyperuricemia and oxidative stress participate in the pathophysiology of hypertension and its complications. Xanthine dehydrogenase (XDH) produces urate and, in its oxidase isoform, reactive oxygen species. Here we have studied whether or not the genetic variations in XDH could be implicated in hypertension and its complications. By sequencing the promoter region and all exons of...

Virulence of Endemic Nonpigmented Northern Australian Staphylococcus aureus Clone (Clonal Complex 75, S. argenteus) Is Not Augmented by Staphyloxanthin

Staphylococcus aureus clonal complex 75 (herein referred to as S. argenteus) lacks the carotenoid pigment operon, crtOPQMN, responsible for production of the putative virulence factor, staphyloxanthin. Although a common cause of community-onset skin infections among Indigenous populations in northern Australia, this clone is infrequently isolated from hospital-based patients with...