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Combined treatment with electrical stimulation and insulin-like growth factor-1 promotes bone regeneration in vitro

.31572217. Author Contributions Data curation: Shuang Zheng. Formal analysis: Su Pan, Yue Ma. Methodology: Jincheng Wang, Xiaoyu Yang. Resources: Peng Xia, Chuan Fu. Software: Yuxin Chang. Validation

Pulsed lavage cleansing of osteochondral grafts depends on lavage duration, flow intensity, and graft storage condition

Introduction Osteochondral allograft (OCA) transplantation is generally effective for treating large cartilage lesions. Cleansing OCA subchondral bone to remove donor marrow elements is typically performed with pulsed lavage. However, the effects of clinical and experimental parameters on OCA marrow removal by pulsed lavage are unknown. The aim of the current study was to...

Remission of Collagen-Induced Arthritis through Combination Therapy of Microfracture and Transplantation of Thermogel-Encapsulated Bone Marrow Mesenchymal Stem Cells

The persistent inflammation of rheumatoid arthritis (RA) always leads to partial synovial hyperplasia and the destruction of articular cartilage. Bone marrow mesenchymal stem cells (BMMSCs) have been proven to possess immunosuppressive effects, and widely explored in the treatment of autoimmune diseases. However, poor inhibitory effect on local inflammatory state and limited...

A Novel Controlled-Release System for Antibacterial Enzyme Lysostaphin Delivery Using Hydroxyapatite/Chitosan Composite Bone Cement

of Shanghai High-Tech United Bio- Technological R&D Co. Ltd (SHUB). Jincheng Wang is a Master of Science student of SKLGE in College of Life Sciences of Fudan University. Yihan Wang, Jien Zhang, Min Lu

A Pilot Study for Control of Hyperendemic Cystic Hydatid Disease in China

Background Cystic hydatid disease (CHD) is a global parasitic zoonosis caused by the dog tapeworm, Echinococcus granulosus. The disease is hyperendemic in western China because of poor economic development; limited community knowledge of CHD; widespread, small-scale household animal production; home killing of livestock; and the feeding of dogs with uncooked offal. Methodology...

Vaccination of Dogs against Echinococcus granulosus the Cause of Cystic Hydatid Disease in Humans

Dogs are pivotal in Echinococcus granulosus transmission to humans, and dog vaccination provides a very practical and cost-effective prevention strategy. We vaccinated dogs with soluble native proteins isolated from protoscoleces of E. granulosus and induced significant suppression of worm growth and egg production. Accordingly, we tested for vaccine efficacy using recombinant...