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A Genetic Variant in miR-196a2 Increased Digestive System Cancer Risks: A Meta-Analysis of 15 Case-Control Studies

Background MicroRNAs (miRNAs) negatively regulate the gene expression and act as tumor suppressors or oncogenes in oncogenesis. The association between single nucleotide polymorphism (SNP) in miR-196a2 rs11614913 and the susceptibility of digestive system cancers was inconsistent in previous studies. Methodology/Principal Findings An updated meta-analysis based on 15 independent...

A Novel Algorithm for Satellite Images Fusion Based on Compressed Sensing and PCA

This paper studies the image fusion of high-resolution panchromatic image and low-resolution multispectral image. Based on the classic fusion algorithms on remote sensing image fusion, the PCA (principal component analysis) transform, and discrete wavelet transform, we carry out in-depth research. The compressed sensing (CS) abandons the full sample and shifts the sampling of the...

A new mechanism of trastuzumab resistance in gastric cancer: MACC1 promotes the Warburg effect via activation of the PI3K/AKT signaling pathway

Background Trastuzumab, a humanized antibody targeting HER2, exhibits remarkable therapeutic efficacy against HER2-positive gastric cancer. However, recurrent therapeutic resistance presents revolutionary claims. Warburg effect and AKT signaling pathway was involved in the resistance to trastuzumab. Our previous studies have demonstrated that overexpression of metastasis...

A simple stem taper model with mixed effects for boreal black spruce

We simplified Kozak’s taper model by setting the inflection point at 1.3 m (dbh) without losing accuracy and precision. The simplification was required to facilitate the estimation of the covariance parameters when using a mixed-effects method. This method was necessary to take into account the correlation among multiple diameter measurements on an individual stem. The simple...

ARG-walker: inference of individual specific strengths of meiotic recombination hotspots by population genomics analysis

Background Meiotic recombination hotspots play important roles in various aspects of genomics, but the underlying mechanisms for regulating the locations and strengths of recombination hotspots are not yet fully revealed. Most existing algorithms for estimating recombination rates from sequence polymorphism data can only output average recombination rates of a population...

Adjuvant Chemotherapy, with or without Taxanes, in Early or Operable Breast Cancer: A Meta-Analysis of 19 Randomized Trials with 30698 Patients

Background Taxanes have been extensively used as adjuvant chemotherapy for the treatment of early or operable breast cancer, particularly in high risk, node-negative breast cancer. Previous studies, however, have reported inconsistent findings regarding their clinical efficacy and safety. We investigated disease-free survival (DFS), overall survival (OS), and drug-related...

Adverse Drug Reactions of Spontaneous Reports in Shanghai Pediatric Population

Background Knowledge of drug safety in the pediatric population of China is limited. This study was designed to evaluate ADRs in children reported to the spontaneous reporting system (SRS) of Shanghai in 2009. Methodology and Principal Findings Crude ADR reports submitted to Shanghai SRS in 2009 for individuals aged from birth to 17 years (including 17 years) were included. Data...

Adverse Effect of Nano-Silicon Dioxide on Lung Function of Rats with or without Ovalbumin Immunization

Background The great advances of nanomaterials have brought out broad important applications, but their possible nanotoxicity and risks have not been fully understood. It is confirmed that exposure of environmental particulate matter (PM), especially ultrafine PM, are responsible for many lung function impairment and exacerbation of pre-existing lung diseases. However, the...

Analysis of 3 Algorithms for Syphilis Serodiagnosis and Implications for Clinical Management

Background. Algorithms for the diagnosis of syphilis continue to be a source of great controversy, and numerous test interpretations have perplexed many clinicians. Methods. We conducted a cross-sectional study of 24 124 subjects to analyze 3 syphilis testing algorithms: traditional algorithm, reverse algorithm, and the European Centre for Disease Prevention and Control (ECDC...

Analysis of Enhanced Current-Generating Mechanism of Geobacter sulfurreducens Strain via Model-Driven Metabolism Simulation

Microbial fuel cells (MFCs) are a class of ideal technologies that function via anaerobic respiration of electricigens, which bring current generation and environmental restoration together. An in-depth understanding of microbial metabolism is of great importance in engineering microbes to further improve their respiration. We employed flux balance analysis and selected Fe(iii...

Analytical Model for Optical Scattering of Infrared Laser by Nonspherical Raindrops

Academic Editor: Yu S. Kivshar Copyright © 2015 Jing Guo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and

Angiotensin II plasma levels are linked to disease severity and predict fatal outcomes in H7N9-infected patients

is a leading principal investigator of the NSFC Innovative Research Group (grant 81321063). Author information Author notesFengming Huang, Jing Guo, Zhen Zou, Jun Liu, Bin Cao & Shuyang Zhang These ... Control and Prevention (China CDC), Beijing 102206, ChinaGeorge F. Gao AuthorsSearch for Fengming Huang in:Nature Research journals • PubMed • Google ScholarSearch for Jing Guo in:Nature Research journals

Application of Herbal Medicines with Bitter Flavor and Cold Property on Treating Diabetes Mellitus

Xiaolin Tong and Hongdong Chen proposed the paper topic; Hongdong Chen and Jing Guo wrote the paper and equally contributed to this work and are both first coauthors; Bing Pang and Linhua Zhao selected

Association between egg consumption and cardiovascular disease events, diabetes and all-cause mortality

Purpose The association between egg consumption and cardiovascular disease (CVD) or type 2 diabetes (T2D) remains controversial. We investigated the association between egg consumption and risk of CVD (primary outcome), T2D and mortality in the Caerphilly prospective cohort study (CAPS) and National Diet and Nutritional Survey (NDNS). Methods CAPS included 2512 men aged 45–59...

Association of Glutathione S transferases Polymorphisms with Glaucoma: A Meta-Analysis

Background Glutathione S transferase (GST) polymorphisms have been considered risk factors for the development of glaucoma, including primary open angle glaucoma (POAG) and other types of glaucoma. However, the results remain controversial. In this study, we have conducted a meta-analysis to assess the association between polymorphisms of GSTM1, GSTT1 and GSTP1 and glaucoma risk...

Association of NLRP3 polymorphisms with susceptibility to primary gouty arthritis in a Chinese Han population

College , Nanchong, Sichuan 637000 , China 2 Department of Geriatrics of the Affiliated Hospital of North Sichuan Medical College , Nanchong, Sichuan 637007 , China 3 Jing-Guo Zhou The NLRP3-interleukin1β ... Dr. Yan Cai for helpful discussion and kindly technical support. Author contributions Designed the experiments: Quan-Bo Zhang, Yu-Feng Qing, and Jing-Guo Zhou. Performed the experiments: YuFeng Qing

Association of TLR4 Gene rs2149356 Polymorphism with Primary Gouty Arthritis in a Case-Control Study

Background The toll-like receptor (TLR)4-interleukin1β (IL1β) signaling pathway is involved in the monosodium urate (MSU)-mediated inflammation. The aim of this present study was to determine whether the TLR4 gene rs2149356 SNP is associated with gouty arthritis (GA) susceptibility and whether rs2149356 SNP impacts the TLR4-IL1β signaling pathway molecules expression. Methods and...

Aurora-A promotes the establishment of spindle assembly checkpoint by priming the Haspin-Aurora-B feedback loop in late G2 phase

, Jing Guo & Zhenye YangCenter for Advanced Preclinical Research, the Center for Cancer Research, National Cancer Institute, Frederick, MD, USALucy Lu & Terry Van DykeAnhui Key laboratory for Cellular ... journals • PubMed • Google ScholarSearch for Fangwei Wang in:Nature Research journals • PubMed • Google ScholarSearch for Xuebiao Yao in:Nature Research journals • PubMed • Google ScholarSearch for Jing Guo