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57 papers found.
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Genetic variants of PTGS2, TXA2R and TXAS1 are associated with carotid plaque vulnerability, platelet activation and TXA2 levels in ischemic stroke patients

Contributions Data curation: Yingying Liu. Formal analysis: Hua Luo, Yingying Liu. Funding acquisition: Xingyang Yi. Methodology: Jing Lin. Software: Chun Wang, Yingying Liu. Supervision: Hua Luo. 12 / 15 ... Validation: Chun Wang. Writing ± original draft: Jing Lin. Writing ± review & editing: Xingyang Yi. 13 / 15 14 / 15 1. Donnan GA , Fisher M , Macleod M , Davis SM . Stroke. Lancet 2008 ; 371 : 1612 ± 1623

Transcriptome analysis of Callery pear (Pyrus calleryana) reveals a comprehensive signalling network in response to Alternaria alternata

Conceptualization: Youhong Chang, Jing Lin. Data curation: Jialiang Kan, Tingli Liu. Formal analysis: Jialiang Kan, Tingli Liu, Hui Li. Funding acquisition: Youhong Chang. Investigation: Jialiang Kan, Na Ma, Hui ... Li, Xiaogang Li, Jinyan Wang, Baolong Zhang. Supervision: Youhong Chang, Jing Lin. Writing ± original draft: Jialiang Kan. Writing ± review & editing: Jinyan Wang, Youhong Chang, Jing Lin. 15 / 17 16

Incidence, clinical characteristics, and outcome of interstitial pneumonia in patients with lymphoma

Interstitial pneumonia (IP) is a lethal complication in lymphoma patients undergoing chemotherapy. A total of 2212 consecutive patients diagnosed with lymphoma between 2009 and 2014 were enrolled in the present study. IP was defined as diffuse pulmonary interstitial infiltrate found on computed tomography scans. IP was observed in 106 patients. Of these, 23 patients were excluded ...

Interaction among COX-2, P2Y1 and GPIIIa gene variants is associated with aspirin resistance and early neurological deterioration in Chinese stroke patients

Background The effect of genetic variants on aspirin resistance (AR) remains controversial. We sought to assess the association of genetic variants with AR and early clinical outcomes in patients with acute ischemic stroke (IS). Methods A total of 850 acute IS patients were consecutively enrolled. Platelet aggregation was measured before and after a 7–10 day aspirin treatment. The ...

Preface: Special topic on Metal-organic frameworks (MOFs)

Sci China Chem Preface: Special Topic on Metal-Organic Frameworks (MOFs) EDITORIAL SPECIALl TOPIC Metal-Organic Frameworks (MOFs) Xian-He Bu 1 Jing-Lin Zuo 0 0 Department of Chemistry, Nanjing ... research is focused on the syntheses and applications of multifunctional MOFs, crystal engineering, and magnetic materials. Prof. Jing-Lin Zuo received his B. S. (in 1990) and Ph. D. degrees (in 1997) from

Isolation and identification of flavonoids components from Pteris vittata L.

Background Pteris vittata L. is rich in flavonoids which exhibit different bioactivities. In order to investigate the flavonoids components of P. vittata L., extracts of the plant were isolated by column chromatography on silica gel and Sephadex LH-20. Results Four flavonoids compounds were obtained, the structures were identified as kaempferol (1), quercetin (2), ...

1,25(OH)2D3 and VDR Signaling Pathways Regulate the Inhibition of Dectin-1 Caused by Cyclosporine A in Response to Aspergillus Fumigatus in Human Corneal Epithelial Cells

Background The objective of this study is to observe whether cyclosporine A (CsA) inhibits the expression of dectin-1 in human corneal epithelial cells infected with Aspergillus fumigatus (A. fumigatus) and to investigate the molecular mechanisms of the inhibition. Methods Immortalized human corneal epithelial cells (HCECs) were pretreated with 1,25(OH)2D3 and VDR inhibitor for 1 ...

Genome-wide identification of pear HD-Zip gene family and expression patterns under stress induced by drought, salinity, and pathogen

Homeodomain-leucine zipper (HD-Zip) transcription factor genes are unique in the plant kingdom. Studies have shown that HD-Zip transcription factor has four subfamilies (subfamilies I–IV), and each subfamily exerts similar or diverse functions in the growth and development as well as environmental stress responses of plants. Although a genome-wide analysis of this transcription ...

Discovery of Influenza A Virus Sequence Pairs and Their Combinations for Simultaneous Heterosubtypic Targeting that Hedge against Antiviral Resistance

The multiple circulating human influenza A virus subtypes coupled with the perpetual genomic mutations and segment reassortment events challenge the development of effective therapeutics. The capacity to drug most RNAs motivates the investigation on viral RNA targets. 123,060 segment sequences from 35,938 strains of the most prevalent subtypes also infecting humans–H1N1, 2009 ...

A retrospective analysis of eleven cases of invasive rhino-orbito-cerebral mucormycosis presented with orbital apex syndrome initially

Background Rhino-orbito-cerebral mucormycosis(ROCM) is an invasive fungal infection that usually occurs in immunocompromised patients and sometimes presents as orbital apex syndrome(OAS) initially. It is rapidly fatal without an early diagnosis and treatment. We report the cases of invasive ROCM presenting with OAS initially in order to raise the attention of clinicians. Methods We ...

Role of Dectin-1 in the innate immune response of rat corneal epithelial cells to Aspergillus fumigatus

Background To observe Dectin-1 expression in fungal keratitis on rat models and to determine the role of Dectin-1 in innate immune response to Aspergillus fumigatus. Methods Wistar rats were randomly divided into control, fungal keratitis and pretreatment (pretreated with Laminarin) groups. Samples were used for conducting immunohistochemical staining and real-time PCR to observe ...

Transcriptome sequencing and analysis of major genes involved in calcium signaling pathways in pear plants (Pyrus calleryana Decne.)

Background Pears (Pyrus spp. L.) are an important genus of trees that produce one of the world’s oldest fruit crops. Salinity stress is a common limiting factor for plant productivity that significantly affects the flavor and nutritional quality of pear fruits. Much research has shown that calcium signaling pathways, mediated by Calcineurin B-like proteins (CBLs) and their ...

Improved FTA Methodology and Application to Subsea Pipeline Reliability Design

An innovative logic tree, Failure Expansion Tree (FET), is proposed in this paper, which improves on traditional Fault Tree Analysis (FTA). It describes a different thinking approach for risk factor identification and reliability risk assessment. By providing a more comprehensive and objective methodology, the rather subjective nature of FTA node discovery is significantly reduced ...

In Vivo Biodistribution and Toxicity of Highly Soluble PEG-Coated Boron Nitride in Mice

An 5 Dan Liu 3 Jing Lin 3 Xiaoyong Zhang 4 Wangsuo Wu 3 0 Key Laboratory of Chemistry of Northwestern Plant Resources, Key Laboratory for Natural Medicine of Gansu Province, Institute of Chemical

The role of Syk signaling in antifungal innate immunity of human corneal epithelial cells

Background Fungal keratitis is a kind of intractable and sight-threatening diseases. Spleen-tyrosine kinase (Syk) is a non-receptor tyrosine kinase, which plays an important role in the signaling pathway of the receptors. In the current study, we investigate the expression and function of Syk in human corneal epithelial cells with Aspergillus fumigatus (A. fumigatus) infection. ...

Methodology to Improve Design of Accelerated Life Tests in Civil Engineering Projects

For reliability testing an Energy Expansion Tree (EET) and a companion Energy Function Model (EFM) are proposed and described in this paper. Different from conventional approaches, the EET provides a more comprehensive and objective way to systematically identify external energy factors affecting reliability. The EFM introduces energy loss into a traditional Function Model to ...

Rashba Effect on the Bound Polaron in an Asymmetric Quantum Dot

By using LLP variational method, the Rashba effect on the bound polaron in an asymmetric quantum dot is investigated and the expression of the bound polaron ground state energy is derived. Considering different Coulomb bound potentials, we discuss the relations between the ground state energy and the electron–phonon coupling strength, the wave vector, the transverse effective ...