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Search: authors:"Jing-Xiang Wu"

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Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels

of China to Lei Chen and the China Postdoctoral Science Foundation (2016M600856 and 2017T100014 to Jing-Xiang Wu). Jing-Xiang Wu is supported by the postdoctoral foundation of the Peking-Tsinghua ... -rectifying potassium channel 6; NBD, nucleotide binding domain; SUR, sulfonylurea receptor; TMD0-L0, transmembrane domain 0-loop 0 COMPLIANCE WITH ETHICS GUIDELINES Jing-Xiang Wu, Dian Ding, Mengmeng Wang

Bilateral downregulation of Nav1.8 in dorsal root ganglia of rats with bone cancer pain induced by inoculation with Walker 256 breast tumor cells

Background Rapid and effective treatment of cancer-induced bone pain remains a clinical challenge and patients with bone metastasis are more likely to experience severe pain. The voltage-gated sodium channel Nav1.8 plays a critical role in many aspects of nociceptor function. Therefore, we characterized a rat model of cancer pain and investigated the potential role of Nav1.8...