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Copy number variants of ABCF1, IL17REL, and FCGR3A are associated with the risk of gout

., S.J., Y.W., Y.C., and Y.L. contributed reagents/materials/analysis tools. J.W., Z.D., H.Z., F.Z., and L.J. wrote the paper. Zheng Dong, Yuan Li, Jingru Zhou, Shuai Jiang, Yi Wang, Yulin Chen, Dongbao

Common Variants in LRP2 and COMT Genes Affect the Susceptibility of Gout in a Chinese Population

Gout is a common inflammation disease resulting from an increase in serum uric acid. Nearly 70% of uric acid is excreted via the kidneys. To date, evidence for an association between genetic loci and gout is absent, equivocal or not replicated. Our study aims to test variants in two genes abundantly expressed in the kidney, LRP2 and COMT, for their association with uric acid and...