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Anti-tumor Study of Chondroitin Sulfate-Methotrexate Nanogels

Self-assembly nanogels (NGs) were formed by bioconjugating methotrexate (MTX) with chondroitin sulfate (CS). MTX-CS NGs can greatly enhance the solubility and improve the delivery efficacy of MTX due to the CD44 binding property of CS. Vivo experiments revealed that MTX-CS NGs showed less toxicity than MTX. MTX-CS NGs can improve the anti-tumor effect while reducing the side...

Location of Facility Based on Simulated Annealing and “ZKW” Algorithms

To cope with the facility location problem, a method based on simulated annealing and “ZKW” algorithm is proposed in this article. The method is applied to some real cases, which aims to deploy video content server at appropriate nodes in an undirected graph to satisfy the requirements of the consumption nodes with the least cost. Simulated annealing can easily find the optimum...

A precision fiber bragg grating interrogation system using long-wavelength vertical-cavity surface-emitting laser

This paper presents the development of a cost-effective precision fiber Bragg grating (FBG) interrogation system using long-wavelength vertical-cavity surface-emitting laser (VCSEL). Tuning properties of a long-wavelength VCSEL have been studied experimentally. An approximately quadratic dependence of its wavelength on the injection current has been observed. The overall design...

Transcriptomic profile of leg muscle during early growth in chicken

The early growth pattern, especially the age of peak growth, of broilers affects the time to market and slaughter weight, which in turn affect the profitability of the poultry industry. However, the underlying mechanisms regulating chicken growth and development have rarely been studied. This study aimed to identify candidate genes involved in chicken growth and investigated the...

Analysis of long noncoding RNA and mRNA using RNA sequencing during the differentiation of intramuscular preadipocytes in chicken

Long noncoding RNAs (lncRNAs) regulate metabolic tissue development and function, including adipogenesis. However, little is known about the function and profile of lncRNAs in intramuscular preadipocyte differentiation in chicken. Here, we identified lncRNAs in chicken intramuscular preadipocytes at different differentiation stages using RNA sequencing. A total of 1,311,382,604...

Research on the surface subsidence monitoring technology based on fiber Bragg grating sensing

In order to monitor the process of surface subsidence caused by mining in real time, we reported two types of fiber Bragg grating (FBG) based sensors. The principles of the FBG-based displacement sensor and the FBG-based micro-seismic sensor were described. The surface subsidence monitoring system based on the FBG sensing technology was designed. Some factual application of using...

Prognostic Value of FOXM1 in Patients with Malignant Solid Tumor: A Meta-Analysis and System Review

Forkhead box M1 (FOXM1), a member of the Fox transcription factors family, was closely related with cell cycle. FOXM1 played an important role in MST and prompted a poor prognosis for MST patients. However, there were also some studies revealing no significant association between the FOXM1 expression and prognosis of patients. Therefore, we conducted meta-analysis to investigate...

Association of Psychological Characteristics and Functional Dyspepsia Treatment Outcome: A Case-Control Study

experiments. Jinyu Wang, Huichun Li, Shaohua Yu, and Bin Pan analyzed the data. Yiping Chen, Jinyu Wang, and Risheng Yu wrote the paper. All authors read and approved the final paper. References N. J

Codon optimization, expression, purification, and functional characterization of recombinant human IL-25 in Pichia pastoris

Yushan Liu Chengsheng Wu Jinyu Wang Wei Mo Min Yu 0 ) Key Laboratory of Molecular Medicine , Ministry of Education, Department of Biochemistry and Molecular Biology, Shanghai Medical College, Fudan

Fiber Bragg grating (FBG) sensors used in coal mines

The fiber Bragg grating (FBG) strain sensors were used for on-line monitoring of the stress variation of the lined wall in the gateway retained along the goaf of No. 3203 coal mining face in Dongtan Mine. The results showed that the FBG strain sensor with the wide measuring range could measure the stress variation accurately during the support process of the gateway retained...

Effects of Secondary Metabolite Extract from Phomopsis occulta on β-Amyloid Aggregation

Inhibition of β-amyloid (Aβ) aggregation is an attractive therapeutic and preventive strategy for the discovery of disease-modifying agents in Alzheimer's disease (AD). Phomopsis occulta is a new, salt-tolerant fungus isolated from mangrove Pongamia pinnata (L.) Pierre. We report here the inhibitory effects of secondary metabolites from Ph. occulta on the aggregation of Aβ42. It...

Transcription of Hepatitis B Virus Covalently Closed Circular DNA Is Regulated by CpG Methylation during Chronic Infection

The persistence of hepatitis B virus (HBV) infection is maintained by the nuclear viral covalently closed circular DNA (cccDNA), which serves as transcription template for viral mRNAs. Previous studies suggested that cccDNA contains methylation-prone CpG islands, and that the minichromosome structure of cccDNA is epigenetically regulated by DNA methylation. However, the...

Comparative Analysis of CpG Islands among HBV Genotypes

DNA methylation is being increasingly recognized to play a role in regulation of hepatitis B virus (HBV) gene expression. The aim of this study was to compare the CpG island distribution among different HBV genotypes. We analyzed 176 full-length HBV genomic sequences obtained from the GenBank database, belonging to genotypes A through J, to identify the CpG islands in the HBV...