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Transplantation of HGF gene-engineered skeletal myoblasts improve infarction recovery in a rat myocardial ischemia model

Background Skeletal myoblast transplantation seems a promising approach for the repair of myocardial infarction (MI). However, the low engraftment efficacy and impaired angiogenic ability limit the clinical efficiency of the myoblasts. Gene engineering with angiogenic growth factors promotes angiogenesis and enhances engraftment of transplanted skeletal myoblasts, leading to ...

Maternal cancer and congenital anomalies in children – a Danish nationwide cohort study

Several studies on pregnancy-associated cancers have suggested an association with congenital anomalies in offspring. Previous studies have included maternal cancers diagnosed up to 2 years after pregnancy; however, long latency periods of some cancers mean that cancers diagnosed many years postpartum might have been present during pregnancy in a preclinical state. This paper ...

Maternal Antenatal Bereavement and Neural Tube Defect in Live-Born Offspring: A Cohort Study

Background Maternal emotional stress during pregnancy has previously been associated with congenital neural malformations, but most studies are based on data collected retrospectively. The objective of our study was to investigate associations between antenatal maternal bereavement due to death of a close relative and neural tube defects (NTDs) in the offspring. Methods We ...

Prenatal and early life stress and risk of eating disorders in adolescent girls and young women

Medicine. Compliance with ethical standards Conflict of interest On behalf of Hong Liang, Wei Yuan, Jørn Olsen, Sven Cnattingius, Jiong Li, XiuJuan Su states that there is no conflict of interest. Open

Mortality in Children Aged 0-9 Years: A Nationwide Cohort Study from Three Nordic Countries

Background Mortality in children under five years has been widely studied, whereas mortality at 5–9 years has received little attention. Using unique data from national registers in three Nordic countries, we aimed to characterize mortality directionality in children aged 0 to 9 years. Methods and Findings The cohort study included all children born in Denmark from 1973 to 2008 (n ...

Transarterial injection of recombinant human type-5 adenovirus H101 in combination with transarterial chemoembolization (TACE) improves overall and progressive-free survival in unresectable hepatocellular carcinoma (HCC)

Background The aim of this study was to determine the clinical benefit of transhepatic arterial chemoembolization (TACE) with or without recombinant human adenovirus type 5 (H101) administration for the treatment of patients with hepatocellular carcinoma (HCC). Methods Tumor response, progression-free survival (PFS), and overall survival(OS) were retrospectively evaluated in ...

Prenatal maternal bereavement and risk of eating disorders in infants and toddlers: a population-based cohort study

Sven Cnattingius Krisztina D. László Jiong Li 0 0 Section for Epidemiology, Department of Public Health, Aarhus University , Aarhus 8000 , Denmark 1 Department of Women's and Children's Health Care

Correction: Prenatal Exposure to Maternal Bereavement and Childbirths in the Offspring: A Population-Based Cohort Study

Cnattingius Jiong Li OPEN ACCESS - We recently published a study on the effect of prenatal stress exposure and the offspring probability of having children [1]. We found no overall effect of prenatal

Paternal Age and Offspring Congenital Heart Defects: A National Cohort Study

Paternal age has been associated with offspring congenital heart defects (CHDs), which might be caused by increased mutations in the germ cell line because of cumulated cell replications. Empirical evidences, however, remain inconclusive. Furthermore, it is unknown whether all subtypes of CHDs are affected by paternal age. We aimed to explore the relationship between paternal age ...

Prenatal Parental Separation and Body Weight, Including Development of Overweight and Obesity Later in Childhood

Background Early parental separation may be a stress factor causing a long-term alteration in the hypothalamic-pituitary-adrenal-axis activity possibly impacting on the susceptibility to develop overweight and obesity in offspring. We aimed to examine the body mass index (BMI) and the risk of overweight and obesity in children whose parents lived separately before the child was ...

In-Utero Exposure to Bereavement and Offspring IQ: A Danish National Cohort Study

Background Intelligence is a life-long trait that has strong influences on lifestyle, adult morbidity and life expectancy. Hence, lower cognitive abilities are therefore of public health interest. Our primary aim was to examine if prenatal bereavement measured as exposure to death of a close family member is associated with the intelligence quotient (IQ) scores at 18-years of age ...

Evaluation of the Quality of Guidelines for Myasthenia Gravis with the AGREE II Instrument

Background Clinical practice guidelines (CPGs) are systematically developed statements to assist practitioners in making decisions about appropriate healthcare in specific clinical circumstances. The methodological quality of CPGs for myasthenia gravis (MG) are unclear. Objective To critically evaluate the methodological quality of CPGs for MG using AGREE II instrument. Method A ...

Tween-modified suspension array for sensitive biomolecular detection

Suspension arrays are attracting increasing interest for detecting and quantifying proteins, nucleic acids and other biomolecules. Among various suspension arrays, sillica-based suspension arrays which benefit from low fluorescence background and material stability have been widely used. Sillica-based suspension arrays are often manufactured with the popular aldehyde-aminosilane ...

Prenatal Exposure to Maternal Bereavement and Childbirths in the Offspring: A Population-Based Cohort Study

Introduction The decline in birth rates is a concern in public health. Fertility is partly determined before birth by the intrauterine environment and prenatal exposure to maternal stress could, through hormonal disturbance, play a role. There has been such evidence from animal studies but not from humans. We aimed to examine the association between prenatal stress due to maternal ...

Mortality after Parental Death in Childhood: A Nationwide Cohort Study from Three Nordic Countries

Jiong Li and colleagues examine mortality rates in children who lost a parent before 18 years old compared with those who did not using population-based data from Denmark, Sweden, and Finland. Please

Severe Maternal Stress Exposure Due to Bereavement before, during and after Pregnancy and Risk of Overweight and Obesity in Young Adult Men: A Danish National Cohort Study

Background Perinatal stress may programme overweight and obesity. We examined whether maternal pre- and post-natal bereavement was associated with overweight and obesity in young men. Methods A cohort study was conducted including 119,908 men born from 1976 to 1993 and examined for military service between 2006 and 2011. Among them, 4,813 conscripts were born to mothers bereaved by ...

Birth weight, gestational age, fetal growth and childhood asthma hospitalization

Background Childhood asthma may have a fetal origin through fetal growth and development of the immunocompetence or respiratory organs. Objective We examined to which extent short gestational age, low birth weight and fetal growth restriction were associated with an increased risk of asthma hospitalization in childhood. Methods We undertook a cohort study based on several national ...

Psychological Stress and Hospitalization for Childhood Asthma-a Nationwide Cohort Study in Two Nordic Countries

ObjectiveExposures to psychological stress in early life may contribute to the development or exacerbation of asthma. We undertook a cohort study based on data from several population-based registers in Denmark and Sweden to examine whether bereavement in childhood led to increased asthma hospitalization. MethodsAll singleton children born in Denmark during 1977-2008 and in Sweden ...

Maternal Bereavement During Pregnancy and the Risk of Stillbirth: A Nationwide Cohort Study in Sweden

Epidemiology, Department of Public Health, University of Aarhus, Aarhus, Denmark (Jiong Li, Jrn Olsen); Research Unit and Section of General Practice, Department of Public Health, University of Aarhus, Aarhus

László et al. Respond to “Maternal Stress and Stillbirth”

, Sven Cnattingius); Section for Epidemi- ology, Department of Public Health, University of Aarhus , Aarhus, Denmark (Jiong Li , Jørn Olsen); Research Unit and Section of General Practice, Department of