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Identification of serotonin 2A receptor as a novel HCV entry factor by a chemical biology strategy

documented in immune-competent humanized transgenic mice. Our results not only expand - Lin Cao and Jizheng Chen have contributed equally. the understanding of HCV entry, but also present a promising target

Productive HBV infection of well-differentiated, hNTCP-expressing human hepatoma-derived (Huh7) cells

Feasible and effective cell models for hepatitis B virus (HBV) infection are required for investigating the complete lifecycle of this virus, including the early steps of viral entry. Resistance to dimethyl sulfoxide/polyethylene glycol (DMSO/PEG), hNTCP expression, and a differentiated state are the limiting factors for successful HBV infection models. In the present study, we...

RNA binding protein 24 regulates the translation and replication of hepatitis C virus

Gao, Qi Yang, Min Guo, Wandi Zhu, Yun Wang, Chunchen Wu, Jizheng Chen, Yuan Zhou, Xue Hu, Mengji Lu, Xinwen Chen and Rongjuan Pei declare that they have no conflict of interest. OPEN ACCESS This

MITA/STING and Its Alternative Splicing Isoform MRP Restrict Hepatitis B Virus Replication

An efficient clearance of hepatitis B virus (HBV) requires the coordinated work of both the innate and adaptive immune responses. MITA/STING, an adapter protein of the innate immune signaling pathways, plays a key role in regulating innate and adaptive immune responses to DNA virus infection. Previously, we identified an alternatively spliced isoform of MITA/STING, called MITA...

Hepatitis C Virus Induced a Novel Apoptosis-Like Death of Pancreatic Beta Cells through a Caspase 3-Dependent Pathway

Epidemiological and experimental studies have suggested that Hepatitis C virus (HCV) infection is associated with the development of type 2 diabetes. Pancreatic beta cell failure is central to the progression of type 2 diabetes. Using virus infection system, we investigate the influence of HCV infection on the fate of the insulinoma cell line, MIN6. Our experiments demonstrate...