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CT Angiography in the Lower Extremity Peripheral Artery Disease Feasibility of an Ultra-Low Volume Contrast Media Protocol

PurposeThe ALARA principle is not only relevant for effective dose (ED) reduction, but also applicable for contrast media (CM) management. Therefore, the aim was to evaluate the feasibility of an ultra-low CM protocol in the assessment of peripheral artery disease (PAD). Materials and methodsFifty PAD patients were scanned on third-generation dual-source computed tomography, from...

Do CTA measurements of annular diameter, perimeter and area result in different TAVI prosthesis sizes?

Incorrect prosthesis size has direct impact on patient outcome after transcatheter aortic valve implantation (TAVI) procedure. Currently, annular diameter, area or perimeter may be used for prosthesis size selection. The aim was to evaluate whether the use different annular dimensions would result in the selection of different prosthesis sizes, when assessed in the same TAVI...

Gadobutrol versus gadofosveset-trisodium in MR venography of the lower extremities

Objectives MR venography (MRV) protocols have used bloodpool contrast agents and long scan sequences to identify patients suitable for treatment and preoperatively. However, variable availability of bloodpool contrast agents, high costs and a need to shorten acquisition times for routine MR protocols hamper everyday practice. Materials 20 patients (11 men; mean age 54 ± 11.8...

Validation of myocardial perfusion quantification by dynamic CT in an ex-vivo porcine heart model

To test the accuracy of quantification of myocardial perfusion imaging (MPI) using computed tomography (CT) in ex-vivo porcine models. Five isolated porcine hearts were perfused according to Langendorff. Hearts were perfused using retrograde flow through the aorta and blood flow, blood pressure and heart rate were monitored throughout the experiment. An inflatable cuff was placed...

Personalized Feedback on Staff Dose in Fluoroscopy-Guided Interventions: A New Era in Radiation Dose Monitoring

Joachim E. Wildberger Purpose Radiation safety and protection are a key component of fluoroscopy-guided interventions. We hypothesize that providing weekly personal dose feedback will increase radiation ... of patient and staff doses, while educating staff and initiating a change in behavior. Compliance with Ethical Standards Conflict of interest Anna M. Sailer, Laura Vergoossen, Marco Das, Joachim E

Heart rate lowering treatment leads to a reduction in vulnerable plaque features in atherosclerotic rabbits

. Hoeks, JeÂroÃme Roussel, Mat J. A. P. Daemen, Harry Struijker-Boudier, Joachim E. Wildberger, Sylvia Heeneman, M. Eline Kooi. Data curation: Raf H. M. van Hoof, Evelien Hermeling, M. Eline Kooi. Formal ... . Hoeks, Joachim E. Wildberger, Sylvia Heeneman, M. Eline Kooi. Validation: Raf H. M. van Hoof, Evelien Hermeling, Judith C. Sluimer, M. Eline Kooi. Visualization: Raf H. M. van Hoof, Evelien Hermeling

Hybrid 18F–FDG PET/MRI might improve locoregional staging of breast cancer patients prior to neoadjuvant chemotherapy

Purpose Our purpose in this study was to assess the added clinical value of hybrid 18F–FDG-PET/MRI compared to conventional imaging for locoregional staging in breast cancer patients undergoing neoadjuvant chemotherapy (NAC). Methods In this prospective study, primary invasive cT2-4 N0 or cT1-4 N+ breast cancer patients undergoing NAC were included. A PET/MRI breast protocol was...

Dynamic Contrast-Enhanced MRI to Study Atherosclerotic Plaque Microvasculature

manuscript. Compliance with Ethical Standards Conflict of Interest Raf H.M. van Hoof declares grant support from CTMM. Sylvia Heeneman declares no conflict of interest. Joachim E. Wildberger declares grant

Early X-ray workers: an effort to assess their numbers, risk, and most common (skin) affliction

Joachim E. Wildberger 0 0 Departments of Radiology and Nuclear Medicine, Maastricht University Medical Center , P. Debijelaan 25, 6229 HX Maastricht , The Netherlands 1 Gerrit J. Kemerink Objective To

Feasibility of in vivo 18F-florbetaben PET/MR imaging of human carotid amyloid-β

Purpose Amyloid-beta (Aβ) peptides are involved in the inflammatory pathology of atherosclerosis. 18F-Florbetaben is a PET tracer for clinical imaging of cerebral Aβ plaques in Alzheimer’s disease (AD). We sought to determine whether specific uptake of 18F-florbetaben in the carotid arteries can be identified using a fully integrated hybrid PET/MRI system and whether this uptake...

Real-Time Patient and Staff Radiation Dose Monitoring in IR Practice

Purpose Knowledge of medical radiation exposure permits application of radiation protection principles. In our center, the first dedicated real-time, automated patient and staff dose monitoring system (DoseWise Portal, Philips Healthcare) was installed. Aim of this study was to obtain insight in the procedural and occupational doses. Materials and Methods All interventional...

Dual-Energy CT: What the Neuroradiologist Should Know

Siemens Healthcare, personal fees from Bayer Healthcare, personal fees from Siemens Healthcare. Dr. Joachim E. Wildberger reports grants from Agfa Healthcare, grants from Bayer Healthcare, grants from GE

Contrast Enhancement of the Right Ventricle during Coronary CT Angiography – Is It Necessary?

Purpose It is unclear if prolonged contrast media injection, to improve right ventricular visualization during coronary CT angiography, leads to increased detection of right ventricle pathology. The purpose of this study was to evaluate right ventricle enhancement and subsequent detection of right ventricle disease during coronary CT angiography. Materials and Methods 472...

CT-Guided Percutaneous Transthoracic Needle Biopsies Using 10G Large-Core Needles: Initial Experience

molecular testing in lung cancer in order to guarantee best patient care. Conflict of interest Ulrich C Lalji, MD, Joachim E Wildberger, MD, PhD, Axel Zur Hausen, MD, PhD, Matyas Bendek, MD, AnneMarie C

High-Sensitivity Cardiac Troponin Concentrations in Patients with Chest Discomfort: Is It the Heart or the Kidneys As Well?

Background High-sensitivity cardiac troponins (hs-cTn) are the preferred biomarkers to detect myocardial injury, making them promising risk-stratifying tools for patients with symptoms of chest pain. However, circulating hs-cTn are also elevated in other conditions like renal dysfunction, complicating appropriate interpretation of low-level hs-cTn concentrations. Methods A cross...

Low contrast media volume in pre-TAVI CT examinations

Purpose To evaluate image quality using reduced contrast media (CM) volume in pre-TAVI assessment. Methods Forty-seven consecutive patients referred for pre-TAVI examination were evaluated. Patients were divided into two groups: group 1 BMI < 28 kg/m2 (n = 29); and group 2 BMI > 28 kg/m2 (n = 18). Patients received a combined scan protocol: retrospective ECG-gated helical CTA of...

Multiparametric imaging of patient and tumour heterogeneity in non-small-cell lung cancer: quantification of tumour hypoxia, metabolism and perfusion

Purpose Multiple imaging techniques are nowadays available for clinical in-vivo visualization of tumour biology. FDG PET/CT identifies increased tumour metabolism, hypoxia PET visualizes tumour oxygenation and dynamic contrast-enhanced (DCE) CT characterizes vasculature and morphology. We explored the relationships among these biological features in patients with non-small-cell...

Functional MRI in Peripheral Arterial Disease: Arterial Peak Flow versus Ankle-Brachial Index

Objectives The purpose of this study was to compare the success rate of successful arterial peak flow (APF) and ankle-brachial index (ABI) measurements in patients with suspected or known peripheral arterial disease (PAD). Materials and Methods 183 patients with varying degrees of PAD were included. All subjects underwent ABI measurements and MR imaging of the popliteal artery to...

Cost-effectiveness of CTA, MRA and DSA in patients with non-traumatic subarachnoid haemorrhage

Objectives Intra-arterial digital subtraction angiography (DSA), magnetic resonance angiography (MRA) and computed tomographic angiography (CTA) are imaging modalities used for diagnostic work-up of non-traumatic subarachnoid haemorrhage. The aim of our study was to compare the cost-effectiveness of MRA, DSA and CTA in the first year after the bleed. Methods A decision model was...