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9 papers found.
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Long-term outcome of vaginal mesh or native tissue in recurrent prolapse: a randomized controlled trial

Introduction and hypothesis Our aim was to evaluate clinically relevant long-term outcomes of transvaginal mesh or native tissue repair in women with recurrent pelvic organ prolapse (POP). Methods We performed a 7-year follow-up of a randomized controlled trial on trocar-guided mesh placement or native tissue repair in women with recurrent POP. Primary outcome was composite ...

Facilitating healthcare decisions by assessing the certainty in the evidence from preclinical animal studies

M. Leeflang, Joanna IntHout, Kimberley E. Wever, Hans de Beer, 14 / 18 Malcolm R. Macleod, Gerben ter Riet, Kristina A. Thayer, Andrew A. Rooney, Holger J. SchuÈnemann, Miranda W. Langendam. Writing ... ± original draft: Carlijn R. Hooijmans, Miranda W. Langendam. Writing ± review & editing: Carlijn R. Hooijmans, Rob B. M. de Vries, Merel Ritskes-Hoitinga, Maroeska M. Rovers, Mariska M. Leeflang, Joanna

A Network Meta-Analysis of Clinical Management Strategies for Treatment-Resistant Hypertension: Making Optimal Use of the Evidence

Background With the addition of surgical interventions to current medicinal treatments, it is increasingly challenging for clinicians to rationally choose among the various options for treating patients with apparent treatment-resistant hypertension (ATRHTN). This study aims to establish the comparative effectiveness of mineralocorticoid receptor antagonists (MRA), renal ...

Risk factors for pelvic organ prolapse and its recurrence: a systematic review

Introduction and hypothesis Pelvic organ prolapse (POP) is a common condition with multifactorial etiology. The purpose of this systematic review was to provide an overview of literature on risk factors for POP and POP recurrence. Methods PubMed and Embase were searched with “pelvic organ prolapse” combined with “recurrence” and combined with “risk factors,” with Medical Subject ...

The Hartung-Knapp-Sidik-Jonkman method for random effects meta-analysis is straightforward and considerably outperforms the standard DerSimonian-Laird method

Background The DerSimonian and Laird approach (DL) is widely used for random effects meta-analysis, but this often results in inappropriate type I error rates. The method described by Hartung, Knapp, Sidik and Jonkman (HKSJ) is known to perform better when trials of similar size are combined. However evidence in realistic situations, where one trial might be much larger than the ...

Tissue Engineering in Animal Models for Urinary Diversion: A Systematic Review

Tissue engineering and regenerative medicine (TERM) approaches may provide alternatives for gastrointestinal tissue in urinary diversion. To continue to clinically translatable studies, TERM alternatives need to be evaluated in (large) controlled and standardized animal studies. Here, we investigated all evidence for the efficacy of tissue engineered constructs in animal models for ...

Cytotoxic Markers Associate With Protection Against Malaria in Human Volunteers Immunized With Plasmodium falciparum Sporozoites

Background. Immunization of healthy volunteers by bites from Plasmodium falciparum–infected mosquitoes during chloroquine chemoprophylaxis (hereafter, chemoprophylaxis and sporozoites [CPS] immunization) induces sterile protection against malaria. CPS-induced protection is mediated by immunity against pre-erythrocytic stages, presumably at least partially by cytotoxic cellular ...

Cytoreductive surgery followed by chemotherapy versus chemotherapy alone for recurrent platinum-sensitive epithelial ovarian cancer (SOCceR trial): a multicenter randomised controlled study

Eltjo MJ Schutter Harold MP Pelikan Jos HA Vollebergh Mirjam JA Engelen Joanna IntHout Roy FPM Kruitwagen Leon FAG Massuger 0 0 Department of Obstetrics and Gynecology, Radboud University Medical Centre