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8 papers found.
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Uveal Melanoma Cells Utilize a Novel Route for Transendothelial Migration

Uveal melanoma arises in the eye, and it spreads to distant organs in almost half of patients, leading to a fatal outcome. To metastasize, uveal melanoma cells must transmigrate into and out of the microvasculature, crossing the monolayer of endothelial cells that separates the vessel lumen from surrounding tissues. We investigated how human uveal melanoma cells cross the ...

Role of Cortactin Homolog HS1 in Transendothelial Migration of Natural Killer Cells

Natural Killer (NK) cells perform many functions that depend on actin assembly, including adhesion, chemotaxis, lytic synapse assembly and cytolysis. HS1, the hematopoietic homolog of cortactin, binds to Arp2/3 complex and promotes actin assembly by helping to form and stabilize actin filament branches. We investigated the role of HS1 in transendothelial migration (TEM) by NK ...

A Novel Role for the GTPase-Activating Protein Bud2 in the Spindle Position Checkpoint

The spindle position checkpoint (SPC) ensures correct mitotic spindle position before allowing mitotic exit in the budding yeast Saccharomyces cerevisiae. In a candidate screen for checkpoint genes, we identified bud2Δ as deficient for the SPC. Bud2 is a GTPase activating protein (GAP), and the only known substrate of Bud2 was Rsr1/Bud1, a Ras-like GTPase and a central component of ...

Dynein and Dynactin Leverage Their Bivalent Character to Form a High-Affinity Interaction

Cytoplasmic dynein and dynactin participate in retrograde transport of organelles, checkpoint signaling and cell division. The principal subunits that mediate this interaction are the dynein intermediate chain (IC) and the dynactin p150Glued; however, the interface and mechanism that regulates this interaction remains poorly defined. Herein, we use multiple methods to show the ...

Distinct Roles for Arp2/3 Regulators in Actin Assembly and Endocytosis

The Arp2/3 complex is essential for actin assembly and motility in many cell processes, and a large number of proteins have been found to bind and regulate it in vitro. A critical challenge is to understand the actions of these proteins in cells, especially in settings where multiple regulators are present. In a systematic study of the sequential multicomponent actin assembly ...

Automatization and perceptual restructuring performance across the menstrual cycle

The cognitive performance of undergraduate psychology women (n=49) and men (n=48) was assessed using standardized automatization and perceptual restructuring measures. Women were classified into five groups based on the phase of the menstrual cycle they were experiencing at the time of testing. Results showed that the automatization performance of women who were expecting to ...

Field independence/dependence, sex, and water levels

should be made to Sherman Ross, Department of Psychology, Howard University , Washington, D.C. 20059 2 JEROME H. BLUE, JOHN A. COOPER, and SHERMAN ROSS Howard University , Washington, D. C. 20059 3