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Interaction between polymorphisms in aspirin metabolic pathways, regular aspirin use and colorectal cancer risk: A case-control study in unselected white European populations

Northwood, Jennifer H. Barrett, Robert Haile, Graham Casey, Mark Jenkins, Aung Ko Win, John L. Hopper, Loic Le Marchand, Noralane M. Lindor, Stephen N. Thibodeau, John D. Potter, John Burn, D. Timothy Bishop ... Jenkins, Aung Ko Win, John L. Hopper, Loic Le Marchand, Noralane M. Lindor, Stephen N. Thibodeau, John D. Potter, John Burn, D. Timothy Bishop. Methodology: Harsh Sheth, Dominique Scherer, Michael S

Exploratory plasma proteomic analysis in a randomized crossover trial of aspirin among healthy men and women

Long-term use of aspirin is associated with lower risk of colorectal cancer and other cancers; however, the mechanism of chemopreventive effect of aspirin is not fully understood. Animal studies suggest that COX-2, NFκB signaling and Wnt/β-catenin pathways may play a role, but no clinical trials have systematically evaluated the biological response to aspirin in healthy humans...

The failure of cancer chemoprevention

overview . Carcinogenesis , 31 , 1703 - 1709 . 2. Steward , W.P. et  al. ( 2013 ) Cancer chemoprevention: a rapidly evolving field . Br. J. Cancer , 109 , 1 - 7 . 3. WCRF/AICR Expert Panel (Chair: John D ... Potter) ( 1997 ) Food, Nutrition and the Prevention of Cancer: A Global Perspective . American Institute for Cancer Research, Washington, DC. 4. WCRF/AICR Expert Panel (Chair: Michael Marmot) ( 2007 ) Food

Enrichment of colorectal cancer associations in functional regions: Insight for using epigenomics data in the analysis of whole genome sequence-imputed GWAS data

. Jenkins, Suzanne M. Leal, Mathieu Lemire, Polly A. Newcomb, Steven Gallinger, John D. Potter, Robert E. Schoen, Martha L. Slattery, Joshua D. Smith, Loic Le Marchand, Emily White, Brent W. Zanke, Anshul

Association between type 2 diabetes and risk of cancer mortality: a pooled analysis of over 771,000 individuals in the Asia Cohort Consortium

Aims/hypothesis The aims of the study were to evaluate the association between type 2 diabetes and the risk of death from any cancer and specific cancers in East and South Asians. Methods Pooled analyses were conducted of 19 prospective population-based cohorts included in the Asia Cohort Consortium, comprising data from 658,611 East Asians and 112,686 South Asians. HRs were used...

Cytomegalovirus and Epstein-Barr Virus in Breast Cancer

Findings of polymerase chain reaction (PCR) studies of cytomegalovirus (CMV) and Epstein-Barr virus (EBV) and breast cancer vary, making it difficult to determine whether either, both, or neither virus is causally associated with breast cancer. We investigated CMV and EBV in paired samples of breast cancer and normal breast tissue from 70 women using quantitative PCR. A serum...

Height as an Explanatory Factor for Sex Differences in Human Cancer

Background Most cancers occur more frequently in men. Numerous explanations for this excess risk have been proposed, yet no study has quantified the degree to which height explains the sex difference even though greater height has been associated with increased risk for many cancers.

Models of carcinogenesis: an overview

At least five coherent models of carcinogenesis have been proposed in the history of cancer research in the last century. Model 1 is mainly centered around mutations, and its main focus is on the chemical environment, radiation and viruses. Model 2 has to do mainly with genome instability and it focuses on familiality. Model 3 is based on non-genotoxic mechanisms, and clonal...

Rare Circulating MicroRNAs as Biomarkers of Colorectal Neoplasia

Background MicroRNAs (miRNAs) are regulatory RNAs, stable in circulation, and implicated in colorectal cancer (CRC) etiology and progression. Therefore they are promising as early detection biomarkers of colorectal neoplasia. However, many circulating miRNAs are highly expressed in blood cells, and therefore may not be specific to colorectal neoplasia. Methods We selected 7 miRNA...

Tissue-specific patterns of gene expression in the epithelium and stroma of normal colon in healthy individuals in an aspirin intervention trial

Background Regular aspirin use reduces colon adenoma and carcinoma incidence. UDP-glucuronosyltransferases (UGT) are involved in aspirin metabolism and clearance, and variant alleles in UGT1A6 have been shown to alter salicylic acid metabolism and risk of colon neoplasia. Methods In a randomized, cross-over, placebo-controlled trial of 44 healthy men and women, homozygous for...

Fine-Mapping of Common Genetic Variants Associated with Colorectal Tumor Risk Identified Potential Functional Variants

Genome-wide association studies (GWAS) have identified many common single nucleotide polymorphisms (SNPs) associated with colorectal cancer risk. These SNPs may tag correlated variants with biological importance. Fine-mapping around GWAS loci can facilitate detection of functional candidates and additional independent risk variants. We analyzed 11,900 cases and 14,311 controls in...

Differences in Epidemiologic Risk Factors for Colorectal Adenomas and Serrated Polyps by Lesion Severity and Anatomical Site

. ACKNOWLEDGMENTS Author affiliations: Department of Cancer Prevention, Fred Hutchinson Cancer Research Center, Seattle, Washington (Andrea N. Burnett-Hartman, Michael N. Passarelli, Scott V. Adams, John D. Potter ... , Polly A. Newcomb); Department of Epidemiology, School of Public Health, University of Washington, Seattle, Washington (Andrea N. Burnett-Hartman, Michael N. Passarelli, John D. Potter, Polly A. Newcomb

Invited Commentary: Pancreas Cancer—We Know about Smoking, but Do We Know Anything Else?

John D. Potter ) - What we know with any certainty about pancreas cancer is quite limited. It is a disease of the developed world. It is more common in men than in women, and it has a casefatality

Genetic variation in prostaglandin synthesis and related pathways, NSAID use and colorectal cancer risk in the Colon Cancer Family Registry

Although use of non-steroidal anti-inflammatory drugs (NSAIDs) generally decreases colorectal cancer (CRC) risk, inherited genetic variation in inflammatory pathways may alter their potential as preventive agents. We investigated whether variation in prostaglandin synthesis and related pathways influences CRC risk in the Colon Cancer Family Registry by examining associations...

Associations between genetic variation in RUNX1, RUNX2, RUNX3, MAPK1 and eIF4E and risk of colon and rectal cancer: additional support for a TGF-β-signaling pathway

The Runt-related transcription factors (RUNX), mitogen-activated protein kinase (MAPK) 1 and eukaryotic translation initiation factor 4E (eIF4E) are potentially involved in tumorigenesis. We evaluated genetic variation in RUNX1 (40 tagSNPs), RUNX2 (19 tagSNPs), RUNX3 (9 tagSNPs), MAPK1 (6 tagSNPs), eIF4E (3 tagSNPs), eIF4EBP2 (2 tagSNP) and eIF4EBP3 (2 tagSNPs) to determine...

IκBKβ and NFκB1, NSAID use and risk of colorectal cancer in the Colon Cancer Family Registry

The NFκB-signaling pathway regulates cell proliferation and inflammation. Activation of the pathway is implicated in the etiology of colorectal cancer (CRC). NSAIDs may reduce CRC risk partially through a nuclear factor-kappa B (NFκB)-dependent pathway. In this study, we investigated associations between 34 NFκB1 and 8 IκBKβ tagSNPs and CRC risk and examined interactions with non...

Plausibility of stromal initiation of epithelial cancers without a mutation in the epithelium: a computer simulation of morphostats

Antonio Cappuccio 0 John D Potter 4 Barnett S Kramer 3 0 Bioinformatics and Computational Systems Biology of Cancer, Institut Curie , Paris , France 1 Department of Anatomy and Cell Biology, Tufts

Pivotal Evaluation of the Accuracy of a Biomarker Used for Classification or Prediction: Standards for Study Design

. Potter 0 0 Affiliations of authors: Division of Public Health Sciences, Fred Hutchinson Cancer Research Center , Seattle, WA (MSP, ZF, HJ , JDP); Department of Clinical Epidemiology, Academic Medical

Associations of Body Mass Index, Smoking, and Alcohol Consumption With Prostate Cancer Mortality in the Asia Cohort Consortium

Zheng, Paolo Boffetta, Rashmi Sinha, Daehee Kang, and John D. Potter 3 Author affiliations: Department of Medicine, Vanderbilt University Medical Center , Nashville, Tennessee (Jay H Many potentially ... Cancer Institute, Bethesda, Maryland (Rashmi Sinha); Centre for Public Health Research, Massey University, Wellington, New Zealand (John D. Potter); and Department of Epidemiology, School of Public Health