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8 papers found.
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The p38 mitogen activated protein kinase inhibitor losmapimod in chronic obstructive pulmonary disease patients with systemic inflammation, stratified by fibrinogen: A randomised double-blind placebo-controlled trial

. Lomas, John R. Cockcroft, Ruth Tal-Singer, Michael I. Polkey, Ian B. Wilkinson. Data curation: Marie Fisk, Divya Mohan, Nicholas S. Hopkinson. Formal analysis: Marie Fisk, Julia Forman, James H. F ... . Rudd, Ian B. Wilkinson. Funding acquisition: Joseph Cheriyan, Carmel M. McEniery, John R. Cockcroft, Michael I. Polkey, Ian B. Wilkinson. Investigation: Joseph Cheriyan, Divya Mohan, Jonathan Fuld

Association between egg consumption and cardiovascular disease events, diabetes and all-cause mortality

Purpose The association between egg consumption and cardiovascular disease (CVD) or type 2 diabetes (T2D) remains controversial. We investigated the association between egg consumption and risk of CVD (primary outcome), T2D and mortality in the Caerphilly prospective cohort study (CAPS) and National Diet and Nutritional Survey (NDNS). Methods CAPS included 2512 men aged 45–59...

The Unique Blood Pressures and Pulsatility of LVAD Patients: Current Challenges and Future Opportunities

An increasing number of end-stage heart failure patients are now implanted with continuous-flow left ventricular assist devices (CF-LVADs). Although this therapeutic approach is associated with improved clinical outcomes, continuous flow physiology reduces arterial pulse pressure and pulsatility to an extent that is unique to this population. Recent data suggest that high blood...

Determinants of arterial stiffness in COPD

Background Cardiovascular morbidity and mortality is high in patients with chronic obstructive pulmonary disease (COPD) and arterial stiffness is a potentially modifiable risk factor with added predictive value beyond that obtained from traditional risk factors. Arterial stiffness has been the target of pharmacologic and exercise interventions in patients with COPD, but the...

Target renal damage: the microvascular associations of increased aortic stiffness in patients with COPD

Cockcroft 1 Charlotte E Bolton 0 0 Nottingham Respiratory Research Unit, University of Nottingham, Clinical Sciences Building, City Hospital Campus , Hucknall road, Nottingham NG5 1PB , UK 1 Wales Heart

Does pulmonary rehabilitation address cardiovascular risk factors in patients with COPD?

Background Patients with COPD have an increased risk of cardiovascular disease. Whilst pulmonary rehabilitation has proven benefit for exercise tolerance and quality of life, any effect on cardiovascular risk has not been fully investigated. We hypothesised that pulmonary rehabilitation, through the exercise and nutritional intervention, would address these factors. Methods...

Cardiovascular and musculoskeletal co-morbidities in patients with alpha 1 antitrypsin deficiency

Background Determining the presence and extent of co-morbidities is fundamental in assessing patients with chronic respiratory disease, where increased cardiovascular risk, presence of osteoporosis and low muscle mass have been recognised in several disease states. We hypothesised that the systemic consequences are evident in a further group of subjects with COPD due to Alpha-1...

Use of Arterial Transfer Functions for the Derivation of Central Aortic Waveform Characteristics in Subjects With Type 2 Diabetes and Cardiovascular Disease: Response to Hope et al.

, PHD1 JOHN R. COCKCROFT, BSC, MB2 MICHAEL F. OROURKE, MD, DSC3 From the 1Graduate School of Biomedical Engineering, University of New South Wales, Sydney, Australia; the 2Wales Heart Research Unit